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OSBPL5 (oxysterol binding protein like 5)

Identity

Alias_namesoxysterol binding protein-like 5
Alias_symbol (synonym)KIAA1534
ORP5
Other aliasOBPH1
HGNC (Hugo) OSBPL5
LocusID (NCBI) 114879
Atlas_Id 50662
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 3087116 and ends at 3165352 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CARS (11p15.4) / OSBPL5 (11p15.4)ENOX2 (Xq26.1) / OSBPL5 (11p15.4)OSBPL5 (11p15.4) / ADGRG5 (16q21)
OSBPL5 (11p15.4) / OSBPL5 (11p15.4)OSBPL5 (11p15.4) / RHOG (11p15.4)OSBPL5 (11p15.4) / TECR (19p13.12)
CARS 11p15.4 / OSBPL5 11p15.4ENOX2 Xq26.1 / OSBPL5 11p15.4OSBPL5 11p15.4 GPR114
OSBPL5 11p15.4 / RHOG 11p15.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(X;11)(q26;p15) ENOX2/OSBPL5
CARS/OSBPL5 (11p15)
OSBPL5/RHOG (11p15)
t(11;16)(p15;q21) OSBPL5/ADGRG5


External links

Nomenclature
HGNC (Hugo)OSBPL5   16392
Cards
Entrez_Gene (NCBI)OSBPL5  114879  oxysterol binding protein like 5
AliasesOBPH1; ORP5
GeneCards (Weizmann)OSBPL5
Ensembl hg19 (Hinxton)ENSG00000021762 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000021762 [Gene_View]  ENSG00000021762 [Sequence]  chr11:3087116-3165352 [Contig_View]  OSBPL5 [Vega]
ICGC DataPortalENSG00000021762
TCGA cBioPortalOSBPL5
AceView (NCBI)OSBPL5
Genatlas (Paris)OSBPL5
WikiGenes114879
SOURCE (Princeton)OSBPL5
Genetics Home Reference (NIH)OSBPL5
Genomic and cartography
GoldenPath hg38 (UCSC)OSBPL5  -     chr11:3087116-3165352 -  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OSBPL5  -     11p15.4   [Description]    (hg19-Feb_2009)
EnsemblOSBPL5 - 11p15.4 [CytoView hg19]  OSBPL5 - 11p15.4 [CytoView hg38]
Mapping of homologs : NCBIOSBPL5 [Mapview hg19]  OSBPL5 [Mapview hg38]
OMIM606733   
Gene and transcription
Genbank (Entrez)AB074006 AF331964 AF392453 AF410430 AK055617
RefSeq transcript (Entrez)NM_001144063 NM_020896 NM_145638
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OSBPL5
Cluster EST : UnigeneHs.436166 [ NCBI ]
CGAP (NCI)Hs.436166
Alternative Splicing GalleryENSG00000021762
Gene ExpressionOSBPL5 [ NCBI-GEO ]   OSBPL5 [ EBI - ARRAY_EXPRESS ]   OSBPL5 [ SEEK ]   OSBPL5 [ MEM ]
Gene Expression Viewer (FireBrowse)OSBPL5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)114879
GTEX Portal (Tissue expression)OSBPL5
Human Protein AtlasENSG00000021762-OSBPL5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H0X9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H0X9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H0X9
Splice isoforms : SwissVarQ9H0X9
PhosPhoSitePlusQ9H0X9
Domaine pattern : Prosite (Expaxy)OSBP (PS01013)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)OSBP_sf    Oxysterol-bd    Oxysterol-bd_CS    PH-like_dom_sf    PH_domain   
Domain families : Pfam (Sanger)Oxysterol_BP (PF01237)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam01237    pfam00169   
Domain families : Smart (EMBL)PH (SM00233)  
Conserved Domain (NCBI)OSBPL5
DMDM Disease mutations114879
Blocks (Seattle)OSBPL5
SuperfamilyQ9H0X9
Human Protein Atlas [tissue]ENSG00000021762-OSBPL5 [tissue]
Peptide AtlasQ9H0X9
HPRD09475
IPIIPI00220116   IPI00980129   IPI00910659   IPI00334771   IPI00154388   IPI00985470   IPI00984744   IPI00983146   IPI00983829   IPI00981693   IPI00977356   IPI00983582   IPI00976743   
Protein Interaction databases
DIP (DOE-UCLA)Q9H0X9
IntAct (EBI)Q9H0X9
FunCoupENSG00000021762
BioGRIDOSBPL5
STRING (EMBL)OSBPL5
ZODIACOSBPL5
Ontologies - Pathways
QuickGOQ9H0X9
Ontology : AmiGOphosphatidylserine binding  phospholipid transporter activity  phospholipid transporter activity  endoplasmic reticulum membrane  cytosol  cytosol  cytosol  Golgi to plasma membrane transport  oxysterol binding  cholesterol metabolic process  lipid binding  sterol transporter activity  cholesterol binding  cholesterol binding  phospholipid transport  phospholipid transport  membrane  membrane  integral component of membrane  cholesterol transport  sterol binding  phosphatidylserine acyl-chain remodeling  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  phosphatidylinositol-4-phosphate binding  
Ontology : EGO-EBIphosphatidylserine binding  phospholipid transporter activity  phospholipid transporter activity  endoplasmic reticulum membrane  cytosol  cytosol  cytosol  Golgi to plasma membrane transport  oxysterol binding  cholesterol metabolic process  lipid binding  sterol transporter activity  cholesterol binding  cholesterol binding  phospholipid transport  phospholipid transport  membrane  membrane  integral component of membrane  cholesterol transport  sterol binding  phosphatidylserine acyl-chain remodeling  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  phosphatidylinositol-4-phosphate binding  
NDEx NetworkOSBPL5
Atlas of Cancer Signalling NetworkOSBPL5
Wikipedia pathwaysOSBPL5
Orthology - Evolution
OrthoDB114879
GeneTree (enSembl)ENSG00000021762
Phylogenetic Trees/Animal Genes : TreeFamOSBPL5
HOVERGENQ9H0X9
HOGENOMQ9H0X9
Homologs : HomoloGeneOSBPL5
Homology/Alignments : Family Browser (UCSC)OSBPL5
Gene fusions - Rearrangements
Fusion : MitelmanCARS/OSBPL5 [11p15.4/11p15.4]  [t(11;11)(p15;p15)]  
Fusion : MitelmanENOX2/OSBPL5 [Xq26.1/11p15.4]  [t(X;11)(q26;p15)]  
Fusion : MitelmanOSBPL5/ADGRG5 [11p15.4/16q21]  [t(11;16)(p15;q21)]  
Fusion : MitelmanOSBPL5/RHOG [11p15.4/11p15.4]  [t(11;11)(p15;p15)]  
Fusion PortalCARS 11p15.4 OSBPL5 11p15.4 LUSC
Fusion PortalENOX2 Xq26.1 OSBPL5 11p15.4 BRCA
Fusion PortalOSBPL5 11p15.4 GPR114 BRCA
Fusion PortalOSBPL5 11p15.4 RHOG 11p15.4 BRCA
Fusion : QuiverOSBPL5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOSBPL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OSBPL5
dbVarOSBPL5
ClinVarOSBPL5
1000_GenomesOSBPL5 
Exome Variant ServerOSBPL5
ExAC (Exome Aggregation Consortium)ENSG00000021762
GNOMAD BrowserENSG00000021762
Varsome BrowserOSBPL5
Genetic variants : HAPMAP114879
Genomic Variants (DGV)OSBPL5 [DGVbeta]
DECIPHEROSBPL5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOSBPL5 
Mutations
ICGC Data PortalOSBPL5 
TCGA Data PortalOSBPL5 
Broad Tumor PortalOSBPL5
OASIS PortalOSBPL5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOSBPL5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOSBPL5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OSBPL5
DgiDB (Drug Gene Interaction Database)OSBPL5
DoCM (Curated mutations)OSBPL5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OSBPL5 (select a term)
intoGenOSBPL5
Cancer3DOSBPL5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606733   
Orphanet
DisGeNETOSBPL5
MedgenOSBPL5
Genetic Testing Registry OSBPL5
NextProtQ9H0X9 [Medical]
TSGene114879
GENETestsOSBPL5
Target ValidationOSBPL5
Huge Navigator OSBPL5 [HugePedia]
snp3D : Map Gene to Disease114879
BioCentury BCIQOSBPL5
ClinGenOSBPL5 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD114879
Chemical/Pharm GKB GenePA32829
Clinical trialOSBPL5
Miscellaneous
canSAR (ICR)OSBPL5 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOSBPL5
EVEXOSBPL5
GoPubMedOSBPL5
iHOPOSBPL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:27:55 CET 2018

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