OSBPL8 (oxysterol binding protein like 8)

2015-06-01 Affiliation

Identity

HGNC

OSBPL8

LOCATION

12q21.2

LOCUSID

114882

ALIAS

MST120,MSTP120,ORP8,OSBP10

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 114882
MIM: 606736
HGNC: 16396
Ensembl: ENSG00000091039

Variants:

dbSNP: 114882
ClinVar: 114882
TCGA: ENSG00000091039
COSMIC: OSBPL8

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000091039	ENST00000261183	Q9BZF1
ENSG00000091039	ENST00000261183	A0A024RBB8
ENSG00000091039	ENST00000393249	Q9BZF1
ENSG00000091039	ENST00000393250	Q9BZF1
ENSG00000091039	ENST00000546946	F8VUA7
ENSG00000091039	ENST00000547540	F8VQX7
ENSG00000091039	ENST00000547544	F8W060
ENSG00000091039	ENST00000548341	F8VZ43
ENSG00000091039	ENST00000549570	F8VVD3
ENSG00000091039	ENST00000549646	F8VS33
ENSG00000091039	ENST00000550628	F8W1F1
ENSG00000091039	ENST00000551927	F8VZB8
ENSG00000091039	ENST00000553139	F8VVE7
ENSG00000091039	ENST00000611266	Q9BZF1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
Glycerophospholipid biosynthesis	REACTOME	R-HSA-1483206
Acyl chain remodelling of PS	REACTOME	R-HSA-1482801

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
26206935	2015	INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts.	143
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
27113756	2016	ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function.	50
28970484	2017	ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P ₂) and regulate its level at the plasma membrane.	35
17991739	2008	OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages.	32
29472386	2018	PI(4,5)P₂ controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites.	31
21698267	2011	OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62.	19
17672918	2007	Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.	17
24333576	2014	Adipocyte-derived factors impair insulin signaling in differentiated human vascular smooth muscle cells via the upregulation of miR-143.	9
25596532	2015	Oxysterol-binding protein-related protein 8 (ORP8) increases sensitivity of hepatocellular carcinoma cells to Fas-mediated apoptosis.	9

Citation

Dessen P

OSBPL8 (oxysterol binding protein like 8)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/55260/osbpl8