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OSBPL8 (oxysterol binding protein like 8)

Identity

Alias (NCBI)MST120
MSTP120
ORP8
OSBP10
HGNC (Hugo) OSBPL8
HGNC Alias symbOSBP10
ORP8
MST120
MSTP120
HGNC Previous nameoxysterol binding protein-like 8
LocusID (NCBI) 114882
Atlas_Id 55260
Location 12q21.2  [Link to chromosome band 12q21]
Location_base_pair Starts at 76351798 and ends at 76559771 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHFR (12q24.33) / OSBPL8 (12q21.2)CPSF6 (12q15) / OSBPL8 (12q21.2)FRS2 (12q15) / OSBPL8 (12q21.2)
OSBPL8 (12q21.2) / MINPP1 (10q23.2)OSBPL8 (12q21.2) / OSBPL8 (12q21.2)OSBPL8 (12q21.2) / PTPRR (12q15)
OSBPL8 (12q21.2) / RAB3IP (12q15)OSBPL8 (12q21.2) / TSHZ2 (20q13.2)OSBPL8 (12q21.2) / TSPAN8 (12q21.1)
OSBPL8 (12q21.2) / ZMYM4 (1p34.3)CHFR 12q24.33 / OSBPL8 12q21.2CPSF6 12q15 / OSBPL8 12q21.2
FRS2 12q15 / OSBPL8 12q21.2OSBPL8 12q21.2 / PTPRR 12q15OSBPL8 12q21.2 / RAB3IP 12q15
OSBPL8 12q21.2 / TSHZ2 20q13.2OSBPL8 12q21.2 / TSPAN8 12q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)OSBPL8   16396
Cards
Entrez_Gene (NCBI)OSBPL8    oxysterol binding protein like 8
AliasesMST120; MSTP120; ORP8; OSBP10
GeneCards (Weizmann)OSBPL8
Ensembl hg19 (Hinxton)ENSG00000091039 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000091039 [Gene_View]  ENSG00000091039 [Sequence]  chr12:76351798-76559771 [Contig_View]  OSBPL8 [Vega]
ICGC DataPortalENSG00000091039
TCGA cBioPortalOSBPL8
AceView (NCBI)OSBPL8
Genatlas (Paris)OSBPL8
SOURCE (Princeton)OSBPL8
Genetics Home Reference (NIH)OSBPL8
Genomic and cartography
GoldenPath hg38 (UCSC)OSBPL8  -     chr12:76351798-76559771 -  12q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OSBPL8  -     12q21.2   [Description]    (hg19-Feb_2009)
GoldenPathOSBPL8 - 12q21.2 [CytoView hg19]  OSBPL8 - 12q21.2 [CytoView hg38]
ImmunoBaseENSG00000091039
Genome Data Viewer NCBIOSBPL8 [Mapview hg19]  
OMIM606736   
Gene and transcription
Genbank (Entrez)AB040884 AF173895 AF323730 AF392452 AK055835
RefSeq transcript (Entrez)NM_001003712 NM_001319652 NM_001319653 NM_001319655 NM_020841
Consensus coding sequences : CCDS (NCBI)OSBPL8
Gene ExpressionOSBPL8 [ NCBI-GEO ]   OSBPL8 [ EBI - ARRAY_EXPRESS ]   OSBPL8 [ SEEK ]   OSBPL8 [ MEM ]
Gene Expression Viewer (FireBrowse)OSBPL8 [ Firebrowse - Broad ]
GenevisibleExpression of OSBPL8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)114882
GTEX Portal (Tissue expression)OSBPL8
Human Protein AtlasENSG00000091039-OSBPL8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZF1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZF1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZF1
PhosPhoSitePlusQ9BZF1
Domaine pattern : Prosite (Expaxy)OSBP (PS01013)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)OSBP_sf    Oxysterol-bd    Oxysterol-bd_CS    PH-like_dom_sf    PH_domain   
Domain families : Pfam (Sanger)Oxysterol_BP (PF01237)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam01237    pfam00169   
Domain families : Smart (EMBL)PH (SM00233)  
Conserved Domain (NCBI)OSBPL8
PDB (RSDB)1V88    5U77    5U78   
PDB Europe1V88    5U77    5U78   
PDB (PDBSum)1V88    5U77    5U78   
PDB (IMB)1V88    5U77    5U78   
Structural Biology KnowledgeBase1V88    5U77    5U78   
SCOP (Structural Classification of Proteins)1V88    5U77    5U78   
CATH (Classification of proteins structures)1V88    5U77    5U78   
SuperfamilyQ9BZF1
AlphaFold pdb e-kbQ9BZF1   
Human Protein Atlas [tissue]ENSG00000091039-OSBPL8 [tissue]
HPRD09478
Protein Interaction databases
DIP (DOE-UCLA)Q9BZF1
IntAct (EBI)Q9BZF1
BioGRIDOSBPL8
STRING (EMBL)OSBPL8
ZODIACOSBPL8
Ontologies - Pathways
QuickGOQ9BZF1
Ontology : AmiGOphosphatidylserine binding  protein binding  endoplasmic reticulum membrane  cytosol  cytosol  negative regulation of sequestering of triglyceride  sterol transporter activity  cholesterol binding  cholesterol binding  phospholipid transport  phospholipid transport  sterol transport  membrane  membrane  integral component of membrane  negative regulation of cell migration  nuclear membrane  activation of protein kinase B activity  sterol binding  phosphatidylserine acyl-chain remodeling  intracellular membrane-bounded organelle  fat cell differentiation  positive regulation of glucose import  positive regulation of insulin receptor signaling pathway  positive regulation of protein kinase B signaling  phosphatidylinositol-4-phosphate binding  protein localization to nuclear pore  intermembrane lipid transfer  phosphatidylserine transfer activity  
Ontology : EGO-EBIphosphatidylserine binding  protein binding  endoplasmic reticulum membrane  cytosol  cytosol  negative regulation of sequestering of triglyceride  sterol transporter activity  cholesterol binding  cholesterol binding  phospholipid transport  phospholipid transport  sterol transport  membrane  membrane  integral component of membrane  negative regulation of cell migration  nuclear membrane  activation of protein kinase B activity  sterol binding  phosphatidylserine acyl-chain remodeling  intracellular membrane-bounded organelle  fat cell differentiation  positive regulation of glucose import  positive regulation of insulin receptor signaling pathway  positive regulation of protein kinase B signaling  phosphatidylinositol-4-phosphate binding  protein localization to nuclear pore  intermembrane lipid transfer  phosphatidylserine transfer activity  
NDEx NetworkOSBPL8
Atlas of Cancer Signalling NetworkOSBPL8
Wikipedia pathwaysOSBPL8
Orthology - Evolution
OrthoDB114882
GeneTree (enSembl)ENSG00000091039
Phylogenetic Trees/Animal Genes : TreeFamOSBPL8
Homologs : HomoloGeneOSBPL8
Homology/Alignments : Family Browser (UCSC)OSBPL8
Gene fusions - Rearrangements
Fusion : MitelmanCHFR/OSBPL8 [12q24.33/12q21.2]  
Fusion : MitelmanCPSF6/OSBPL8 [12q15/12q21.2]  
Fusion : MitelmanFRS2/OSBPL8 [12q15/12q21.2]  
Fusion : MitelmanOSBPL8/PTPRR [12q21.2/12q15]  
Fusion : MitelmanOSBPL8/RAB3IP [12q21.2/12q15]  
Fusion : MitelmanOSBPL8/TSHZ2 [12q21.2/20q13.2]  
Fusion : MitelmanOSBPL8/TSPAN8 [12q21.2/12q21.1]  
Fusion : QuiverOSBPL8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOSBPL8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OSBPL8
dbVarOSBPL8
ClinVarOSBPL8
MonarchOSBPL8
1000_GenomesOSBPL8 
Exome Variant ServerOSBPL8
GNOMAD BrowserENSG00000091039
Varsome BrowserOSBPL8
ACMGOSBPL8 variants
VarityQ9BZF1
Genomic Variants (DGV)OSBPL8 [DGVbeta]
DECIPHEROSBPL8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOSBPL8 
Mutations
ICGC Data PortalOSBPL8 
TCGA Data PortalOSBPL8 
Broad Tumor PortalOSBPL8
OASIS PortalOSBPL8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOSBPL8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DOSBPL8
Mutations and Diseases : HGMDOSBPL8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaOSBPL8
DgiDB (Drug Gene Interaction Database)OSBPL8
DoCM (Curated mutations)OSBPL8
CIViC (Clinical Interpretations of Variants in Cancer)OSBPL8
Cancer3DOSBPL8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606736   
Orphanet
DisGeNETOSBPL8
MedgenOSBPL8
Genetic Testing Registry OSBPL8
NextProtQ9BZF1 [Medical]
GENETestsOSBPL8
Target ValidationOSBPL8
Huge Navigator OSBPL8 [HugePedia]
ClinGenOSBPL8
Clinical trials, drugs, therapy
MyCancerGenomeOSBPL8
Protein Interactions : CTDOSBPL8
Pharm GKB GenePA32832
PharosQ9BZF1
Clinical trialOSBPL8
Miscellaneous
canSAR (ICR)OSBPL8
HarmonizomeOSBPL8
DataMed IndexOSBPL8
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXOSBPL8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:23:55 CEST 2021

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