OSCAR (osteoclast associated Ig-like receptor)

2014-11-01  

Identity

HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
PIGR3,PIgR-3

Other Information

Locus ID:

NCBI: 126014
MIM: 606862
HGNC: 29960
Ensembl: ENSG00000170909

Variants:

dbSNP: 126014
ClinVar: 126014
TCGA: ENSG00000170909
COSMIC: OSCAR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170909ENST00000284648Q8IYS5
ENSG00000170909ENST00000351806A0A0A0MR14
ENSG00000170909ENST00000356532A0A087X1R2
ENSG00000170909ENST00000358375A0A0A0MRF2
ENSG00000170909ENST00000359649A0A087WV17
ENSG00000170909ENST00000391760A8MWV3
ENSG00000170909ENST00000391761Q8IYS5
ENSG00000170909ENST00000611261A0A087WV17
ENSG00000170909ENST00000616215Q8IYS5
ENSG00000170909ENST00000616447A0A087X0P3
ENSG00000170909ENST00000617140A0A087X1R2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
161097142005Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis.67
218413092011OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.63
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
211728742011The role of osteoclast-associated receptor in osteoimmunology.21
188216712008Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis.20
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
151554682004OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells.19
257169982015OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes.18
231461952012The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints.16
159055162005CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cells.13

Citation

Dessen P

OSCAR (osteoclast associated Ig-like receptor)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71557/oscar