Atlas of Genetics and Cytogenetics in Oncology and Haematology

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OSM (oncostatin M)

Identity

Alias_symbol (synonym)MGC20461
Other alias-
HGNC (Hugo) OSM
LocusID (NCBI) 5008
Atlas_Id 41615
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 30262828 and ends at 30266843 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GCNT2 (6p24.3) / OSM (22q12.2)GCNT2 6p24.3 / OSM 22q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;22)(p24;q12) GCNT2/OSM

External links

Nomenclature
HGNC (Hugo)OSM   8506
Cards
Entrez_Gene (NCBI)OSM  5008  oncostatin M
Aliases
GeneCards (Weizmann)OSM
Ensembl hg19 (Hinxton)ENSG00000099985 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099985 [Gene_View]  ENSG00000099985 [Sequence]  chr22:30262828-30266843 [Contig_View]  OSM [Vega]
ICGC DataPortalENSG00000099985
TCGA cBioPortalOSM
AceView (NCBI)OSM
Genatlas (Paris)OSM
WikiGenes5008
SOURCE (Princeton)OSM
Genetics Home Reference (NIH)OSM
Genomic and cartography
GoldenPath hg38 (UCSC)OSM  -     chr22:30262828-30266843 -  22q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OSM  -     22q12.2   [Description]    (hg19-Feb_2009)
OSM - 22q12.2 [CytoView hg19]  OSM - 22q12.2 [CytoView hg38]
Mapping of homologs : NCBIOSM [Mapview hg19]  OSM [Mapview hg38]
OMIM165095   
Gene and transcription
Genbank (Entrez)AB451493 BC011589 BM562358 CD368803 CR456534
RefSeq transcript (Entrez)NM_001319108 NM_020530
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OSM
Cluster EST : UnigeneHs.248156 [ NCBI ]
CGAP (NCI)Hs.248156
Alternative Splicing GalleryENSG00000099985
Gene ExpressionOSM [ NCBI-GEO ]   OSM [ EBI - ARRAY_EXPRESS ]   OSM [ SEEK ]   OSM [ MEM ]
Gene Expression Viewer (FireBrowse)OSM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5008
GTEX Portal (Tissue expression)OSM
Human Protein AtlasENSG00000099985-OSM [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13725   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13725  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13725
Splice isoforms : SwissVarP13725
PhosPhoSitePlusP13725
Domaine pattern : Prosite (Expaxy)LIF_OSM (PS00590)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    Leukemia_IF/oncostatin    Leukemia_IF/oncostatin_CS   
Domain families : Pfam (Sanger)LIF_OSM (PF01291)   
Domain families : Pfam (NCBI)pfam01291   
Domain families : Smart (EMBL)LIF_OSM (SM00080)  
Conserved Domain (NCBI)OSM
DMDM Disease mutations5008
Blocks (Seattle)OSM
PDB (RSDB)1EVS   
PDB Europe1EVS   
PDB (PDBSum)1EVS   
PDB (IMB)1EVS   
Structural Biology KnowledgeBase1EVS   
SCOP (Structural Classification of Proteins)1EVS   
CATH (Classification of proteins structures)1EVS   
SuperfamilyP13725
Human Protein Atlas [tissue]ENSG00000099985-OSM [tissue]
Peptide AtlasP13725
HPRD01300
IPIIPI00010336   IPI00878132   IPI00878302   
Protein Interaction databases
DIP (DOE-UCLA)P13725
IntAct (EBI)P13725
FunCoupENSG00000099985
BioGRIDOSM
STRING (EMBL)OSM
ZODIACOSM
Ontologies - Pathways
QuickGOP13725
Ontology : AmiGOpositive regulation of acute inflammatory response  cytokine activity  cytokine activity  oncostatin-M receptor binding  extracellular region  extracellular space  immune response  multicellular organism development  growth factor activity  cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  regulation of signaling receptor activity  positive regulation of phosphatidylinositol 3-kinase signaling  cytokine-mediated signaling pathway  positive regulation of peptidyl-serine phosphorylation  oncostatin-M-mediated signaling pathway  regulation of growth  positive regulation of tyrosine phosphorylation of STAT protein  positive regulation of MAPK cascade  positive regulation of transcription by RNA polymerase II  negative regulation of hormone secretion  positive regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of cell division  positive regulation of protein kinase B signaling  positive regulation of interleukin-17 secretion  
Ontology : EGO-EBIpositive regulation of acute inflammatory response  cytokine activity  cytokine activity  oncostatin-M receptor binding  extracellular region  extracellular space  immune response  multicellular organism development  growth factor activity  cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  regulation of signaling receptor activity  positive regulation of phosphatidylinositol 3-kinase signaling  cytokine-mediated signaling pathway  positive regulation of peptidyl-serine phosphorylation  oncostatin-M-mediated signaling pathway  regulation of growth  positive regulation of tyrosine phosphorylation of STAT protein  positive regulation of MAPK cascade  positive regulation of transcription by RNA polymerase II  negative regulation of hormone secretion  positive regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of cell division  positive regulation of protein kinase B signaling  positive regulation of interleukin-17 secretion  
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway   
NDEx NetworkOSM
Atlas of Cancer Signalling NetworkOSM
Wikipedia pathwaysOSM
Orthology - Evolution
OrthoDB5008
GeneTree (enSembl)ENSG00000099985
Phylogenetic Trees/Animal Genes : TreeFamOSM
HOGENOMP13725
Homologs : HomoloGeneOSM
Homology/Alignments : Family Browser (UCSC)OSM
Gene fusions - Rearrangements
Fusion : MitelmanGCNT2/OSM [6p24.3/22q12.2]  [t(6;22)(p24;q12)]  
Fusion PortalGCNT2 6p24.3 OSM 22q12.2 LUAD
Fusion : QuiverOSM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOSM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OSM
dbVarOSM
ClinVarOSM
1000_GenomesOSM 
Exome Variant ServerOSM
ExAC (Exome Aggregation Consortium)ENSG00000099985
GNOMAD BrowserENSG00000099985
Varsome BrowserOSM
Genetic variants : HAPMAP5008
Genomic Variants (DGV)OSM [DGVbeta]
DECIPHEROSM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOSM 
Mutations
ICGC Data PortalOSM 
TCGA Data PortalOSM 
Broad Tumor PortalOSM
OASIS PortalOSM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOSM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOSM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OSM
DgiDB (Drug Gene Interaction Database)OSM
DoCM (Curated mutations)OSM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OSM (select a term)
intoGenOSM
Cancer3DOSM(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM165095   
Orphanet
DisGeNETOSM
MedgenOSM
Genetic Testing Registry OSM
NextProtP13725 [Medical]
TSGene5008
GENETestsOSM
Target ValidationOSM
Huge Navigator OSM [HugePedia]
snp3D : Map Gene to Disease5008
BioCentury BCIQOSM
ClinGenOSM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5008
Chemical/Pharm GKB GenePA32836
Clinical trialOSM
Miscellaneous
canSAR (ICR)OSM (select the gene name)
DataMed IndexOSM
Probes
Litterature
PubMed150 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOSM
EVEXOSM
GoPubMedOSM
iHOPOSM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 21 16:01:10 CET 2019
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