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OSM (oncostatin M)

Identity

Other namesMGC20461
HGNC (Hugo) OSM
Location 22q12.2
Location_base_pair Starts at 28988819 and ends at 28992840 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)OSM   8506
Entrez_Gene (NCBI)OSM  5008  oncostatin M
Cards
GeneCards (Weizmann)OSM
Ensembl (Hinxton)ENSG00000099985 [Gene_View]  OSM [Vega]
AceView (NCBI)OSM
Genatlas (Paris)OSM
euGene (Indiana)5008
SOURCE (Stanford)NM_020530
Gene Expression (Array Express) ENSG00000099985
Genomic and cartography
GoldenPath (UCSC)OSM  -  22q12.2   chr22:28988819-28992840 -  22q12.2   [Description]    (hg18-March_2006)
EnsemblOSM - 22q12.2 [CytoView]
Mapping of homologs : NCBIOSM [Mapview]
OMIM165095   
Gene and transcription
Gene : Genbank (Entrez)AB451493 BC011589 CR456534 CR541703 CU013134
Reference sequence (RefSeq transcript) :SRSNM_020530
Reference transcript : EntrezNM_020530
RefSeq genomic : SRSAC_000065 AC_000154 NC_000022 NT_011520 NW_001838745 NW_927628
RefSeq genomic : EntrezAC_000065 AC_000154 NC_000022 NT_011520 NW_001838745 NW_927628
Consensus coding sequences : CCDS NCBIOSM
Cluster EST : UnigeneHs.248156 [ SRS ] Hs.248156 [ NCBI ]
Alternative Splicing : Fast-db (Paris)4153
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP13725 (SRS) P13725 (Expasy) P13725 (Uniprot)
With graphics : InterProP13725
Splice isoforms : VarSplice FASTAP13725(VarSplice FASTA)
Domaine pattern : Prosite (SRS)LIF_OSM (PS00590)   
Domain pattern : Prosite (Expaxy)LIF_OSM (PS00590)   
Domains : Interpro (SRS)4_helix_cytokine-like_core    Leukemia_IF/oncostatin    Leukemia_IF/oncostatin_CS   
Domains : Interpro (EBI)4_helix_cytokine-like_core    Leukemia_IF/oncostatin    Leukemia_IF/oncostatin_CS   
Related proteins : CluSTrP13725
Domain families : Pfam SRSLIF_OSM (PF01291)   
Domain families : Pfam SangerLIF_OSM (PF01291)   
Domain families : Pfam NCBIpfam01291   
Domain families : Smart EMBLLIF_OSM (SM00080)  
Blocks (Seattle)P13725
Crystal structure of protein : PDB SRS1EVS   
Crystal structure of protein : PDBSum1EVS   
Crystal structure of protein : IMB1EVS   
Crystal structure of protein : PDB RSDB1EVS   
HPRD01300
Protein Interaction databases
DIP (DOE-UCLA)P13725
IntAct (EBI)P13725
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIOSM
SNP : GeneSNP UtahOSM
SNP : HGBaseOSM
Genetic variants : HAPMAPOSM
Somatic Mutations in Cancer : COSMICOSM 
Mutations and Diseases : HGMDOSM
Hereditary diseases : OMIM165095   
Hereditary diseases : GENETests165095   
Diseases : Genetic AssociationOSM
General knowledge
Homologs : HomoloGeneOSM
Homology/Alignments : Family Browser UCSCOSM
Phylogenetic Trees/Animal Genes : TreeFamOSM
Chemical/Protein Interactions : CTD5008
Keywords Ontology : AmiGOpositive regulation of acute inflammatory response  cytokine activity  oncostatin-M receptor binding  extracellular region  extracellular space  oncostatin-M receptor complex  apoptosis  immune response  multicellular organismal development  peripheral nervous system development  growth factor activity  positive regulation of cell proliferation  negative regulation of cell proliferation  response to heat  positive regulation of peptidyl-serine phosphorylation  regulation of growth  tyrosine phosphorylation of Stat3 protein  tyrosine phosphorylation of Stat5 protein  tyrosine phosphorylation of Stat1 protein  positive regulation of MAPKKK cascade  negative regulation of meiosis  positive regulation of transcription from RNA polymerase II promoter  negative regulation of hormone secretion  behavioral response to pain  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of cell division  
Keywords Ontology : EGO-EBIpositive regulation of acute inflammatory response  cytokine activity  oncostatin-M receptor binding  extracellular region  extracellular space  oncostatin-M receptor complex  apoptosis  immune response  multicellular organismal development  peripheral nervous system development  growth factor activity  positive regulation of cell proliferation  negative regulation of cell proliferation  response to heat  positive regulation of peptidyl-serine phosphorylation  regulation of growth  tyrosine phosphorylation of Stat3 protein  tyrosine phosphorylation of Stat5 protein  tyrosine phosphorylation of Stat1 protein  positive regulation of MAPKKK cascade  negative regulation of meiosis  positive regulation of transcription from RNA polymerase II promoter  negative regulation of hormone secretion  behavioral response to pain  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of cell division  
Pathways : BIOCARTA
Pathways : KEGGCytokine-cytokine receptor interactionJak-STAT signaling pathway
Other databases
Probes
Probes : ImagenesOSM Related clones (RZPD - Berlin)
Literature
PubMed74 Pubmed reference(s) in Entrez
PubGeneOSM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:34:51 CET 2010
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