Atlas of Genetics and Cytogenetics in Oncology and Haematology

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OSM (oncostatin M)

Identity

Other names-
HGNC (Hugo) OSM
LocusID (NCBI) 5008
Location 22q12.2
Location_base_pair Starts at 30658819 and ends at 30662829 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)OSM   8506
Cards
Entrez_Gene (NCBI)OSM  5008  oncostatin M
GeneCards (Weizmann)OSM
Ensembl hg19 (Hinxton)ENSG00000099985 [Gene_View]  chr22:30658819-30662829 [Contig_View]  OSM [Vega]
Ensembl hg38 (Hinxton)ENSG00000099985 [Gene_View]  chr22:30658819-30662829 [Contig_View]  OSM [Vega]
ICGC DataPortalENSG00000099985
cBioPortalOSM
AceView (NCBI)OSM
Genatlas (Paris)OSM
WikiGenes5008
SOURCE (Princeton)OSM
Genomic and cartography
GoldenPath hg19 (UCSC)OSM  -     chr22:30658819-30662829 -  22q12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)OSM  -     22q12.2   [Description]    (hg38-Dec_2013)
EnsemblOSM - 22q12.2 [CytoView hg19]  OSM - 22q12.2 [CytoView hg38]
Mapping of homologs : NCBIOSM [Mapview hg19]  OSM [Mapview hg38]
OMIM165095   
Gene and transcription
Genbank (Entrez)AB451493 BC011589 CR456534 CR541703 CU013134
RefSeq transcript (Entrez)NM_020530
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NT_011520 NW_001838745 NW_004929430
Consensus coding sequences : CCDS (NCBI)OSM
Cluster EST : UnigeneHs.248156 [ NCBI ]
CGAP (NCI)Hs.248156
Alternative Splicing : Fast-db (Paris)GSHG0020297
Alternative Splicing GalleryENSG00000099985
Gene ExpressionOSM [ NCBI-GEO ]     OSM [ SEEK ]   OSM [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13725 (Uniprot)
NextProtP13725  [Medical]
With graphics : InterProP13725
Splice isoforms : SwissVarP13725 (Swissvar)
Domaine pattern : Prosite (Expaxy)LIF_OSM (PS00590)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    Leukemia_IF/oncostatin    Leukemia_IF/oncostatin_CS   
Related proteins : CluSTrP13725
Domain families : Pfam (Sanger)LIF_OSM (PF01291)   
Domain families : Pfam (NCBI)pfam01291   
Domain families : Smart (EMBL)LIF_OSM (SM00080)  
DMDM Disease mutations5008
Blocks (Seattle)P13725
PDB (SRS)1EVS   
PDB (PDBSum)1EVS   
PDB (IMB)1EVS   
PDB (RSDB)1EVS   
Human Protein AtlasENSG00000099985
Peptide AtlasP13725
HPRD01300
IPIIPI00010336   IPI00878132   IPI00878302   
Protein Interaction databases
DIP (DOE-UCLA)P13725
IntAct (EBI)P13725
FunCoupENSG00000099985
BioGRIDOSM
IntegromeDBOSM
STRING (EMBL)OSM
Ontologies - Pathways
QuickGOP13725
Ontology : AmiGOpositive regulation of acute inflammatory response  cytokine activity  oncostatin-M receptor binding  extracellular space  oncostatin-M receptor complex  immune response  multicellular organismal development  peripheral nervous system development  growth factor activity  cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  response to heat  positive regulation of peptidyl-serine phosphorylation  regulation of growth  tyrosine phosphorylation of Stat3 protein  tyrosine phosphorylation of Stat5 protein  tyrosine phosphorylation of Stat1 protein  positive regulation of MAPK cascade  negative regulation of meiosis  positive regulation of transcription from RNA polymerase II promoter  negative regulation of hormone secretion  behavioral response to pain  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of cell division  positive regulation of apoptotic signaling pathway  
Ontology : EGO-EBIpositive regulation of acute inflammatory response  cytokine activity  oncostatin-M receptor binding  extracellular space  oncostatin-M receptor complex  immune response  multicellular organismal development  peripheral nervous system development  growth factor activity  cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  response to heat  positive regulation of peptidyl-serine phosphorylation  regulation of growth  tyrosine phosphorylation of Stat3 protein  tyrosine phosphorylation of Stat5 protein  tyrosine phosphorylation of Stat1 protein  positive regulation of MAPK cascade  negative regulation of meiosis  positive regulation of transcription from RNA polymerase II promoter  negative regulation of hormone secretion  behavioral response to pain  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of cell division  positive regulation of apoptotic signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway   
Protein Interaction DatabaseOSM
DoCM (Curated mutations)OSM
Wikipedia pathwaysOSM
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerOSM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OSM
dbVarOSM
ClinVarOSM
1000_GenomesOSM 
Exome Variant ServerOSM
SNP (GeneSNP Utah)OSM
SNP : HGBaseOSM
Genetic variants : HAPMAPOSM
Genomic VariantsOSM  OSM [DGVbeta]
Mutations
ICGC Data PortalENSG00000099985 
Somatic Mutations in Cancer : COSMICOSM 
CONAN: Copy Number AnalysisOSM 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)22:30658819-30662829
Mutations and Diseases : HGMDOSM
OMIM165095   
MedgenOSM
NextProtP13725 [Medical]
GENETestsOSM
Disease Genetic AssociationOSM
Huge Navigator OSM [HugePedia]  OSM [HugeCancerGEM]
snp3D : Map Gene to Disease5008
DGIdb (Drug Gene Interaction db)OSM
General knowledge
Homologs : HomoloGeneOSM
Homology/Alignments : Family Browser (UCSC)OSM
Phylogenetic Trees/Animal Genes : TreeFamOSM
Chemical/Protein Interactions : CTD5008
Chemical/Pharm GKB GenePA32836
Clinical trialOSM
Cancer Resource (Charite)ENSG00000099985
Other databases
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
CoreMineOSM
GoPubMedOSM
iHOPOSM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 00:40:49 CET 2014
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