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OSMR (oncostatin M receptor)

Identity

Alias_symbol (synonym)OSMRB
Other aliasIL-31R-beta
IL-31RB
PLCA1
HGNC (Hugo) OSMR
LocusID (NCBI) 9180
Atlas_Id 41616
Location 5p13.1  [Link to chromosome band 5p13]
Location_base_pair Starts at 38845858 and ends at 38886739 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EDARADD (1q42.3) / OSMR (5p13.1)OSMR (5p13.1) / FGG (4q31.3)OSMR (5p13.1) / NCKAP5 (2q21.2)
USP37 (2q35) / OSMR (5p13.1)OSMR 5p13.1 / NCKAP5 2q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)OSMR   8507
Cards
Entrez_Gene (NCBI)OSMR  9180  oncostatin M receptor
AliasesIL-31R-beta; IL-31RB; OSMRB; PLCA1
GeneCards (Weizmann)OSMR
Ensembl hg19 (Hinxton)ENSG00000145623 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145623 [Gene_View]  chr5:38845858-38886739 [Contig_View]  OSMR [Vega]
ICGC DataPortalENSG00000145623
TCGA cBioPortalOSMR
AceView (NCBI)OSMR
Genatlas (Paris)OSMR
WikiGenes9180
SOURCE (Princeton)OSMR
Genetics Home Reference (NIH)OSMR
Genomic and cartography
GoldenPath hg38 (UCSC)OSMR  -     chr5:38845858-38886739 +  5p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OSMR  -     5p13.1   [Description]    (hg19-Feb_2009)
EnsemblOSMR - 5p13.1 [CytoView hg19]  OSMR - 5p13.1 [CytoView hg38]
Mapping of homologs : NCBIOSMR [Mapview hg19]  OSMR [Mapview hg38]
OMIM105250   601743   
Gene and transcription
Genbank (Entrez)AI417125 AK304016 BC010943 BC063468 BC125209
RefSeq transcript (Entrez)NM_001168355 NM_001323504 NM_001323505 NM_001323506 NM_001323507 NM_003999
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OSMR
Cluster EST : UnigeneHs.658389 [ NCBI ]
CGAP (NCI)Hs.658389
Alternative Splicing GalleryENSG00000145623
Gene ExpressionOSMR [ NCBI-GEO ]   OSMR [ EBI - ARRAY_EXPRESS ]   OSMR [ SEEK ]   OSMR [ MEM ]
Gene Expression Viewer (FireBrowse)OSMR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9180
GTEX Portal (Tissue expression)OSMR
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99650   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99650  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99650
Splice isoforms : SwissVarQ99650
PhosPhoSitePlusQ99650
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F2 (PS01353)   
Domains : Interpro (EBI)FN3_dom    Hematopoietin_rcpt_Gp130_CS    Ig-like_fold   
Domain families : Pfam (Sanger)fn3 (PF00041)   
Domain families : Pfam (NCBI)pfam00041   
Domain families : Smart (EMBL)FN3 (SM00060)  
Conserved Domain (NCBI)OSMR
DMDM Disease mutations9180
Blocks (Seattle)OSMR
SuperfamilyQ99650
Human Protein AtlasENSG00000145623
Peptide AtlasQ99650
HPRD03446
IPIIPI00022674   IPI00807681   IPI00966487   IPI00965423   IPI00965941   
Protein Interaction databases
DIP (DOE-UCLA)Q99650
IntAct (EBI)Q99650
FunCoupENSG00000145623
BioGRIDOSMR
STRING (EMBL)OSMR
ZODIACOSMR
Ontologies - Pathways
QuickGOQ99650
Ontology : AmiGOpositive regulation of acute inflammatory response  oncostatin-M receptor activity  plasma membrane  oncostatin-M receptor complex  positive regulation of cell proliferation  apical plasma membrane  growth factor binding  response to cytokine  oncostatin-M-mediated signaling pathway  
Ontology : EGO-EBIpositive regulation of acute inflammatory response  oncostatin-M receptor activity  plasma membrane  oncostatin-M receptor complex  positive regulation of cell proliferation  apical plasma membrane  growth factor binding  response to cytokine  oncostatin-M-mediated signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway   
NDEx NetworkOSMR
Atlas of Cancer Signalling NetworkOSMR
Wikipedia pathwaysOSMR
Orthology - Evolution
OrthoDB9180
GeneTree (enSembl)ENSG00000145623
Phylogenetic Trees/Animal Genes : TreeFamOSMR
HOVERGENQ99650
HOGENOMQ99650
Homologs : HomoloGeneOSMR
Homology/Alignments : Family Browser (UCSC)OSMR
Gene fusions - Rearrangements
Fusion : MitelmanOSMR/NCKAP5 [5p13.1/2q21.2]  
Fusion : MitelmanUSP37/OSMR [2q35/5p13.1]  [t(2;5)(q35;p13)]  
Fusion: TCGAOSMR 5p13.1 NCKAP5 2q21.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOSMR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OSMR
dbVarOSMR
ClinVarOSMR
1000_GenomesOSMR 
Exome Variant ServerOSMR
ExAC (Exome Aggregation Consortium)OSMR (select the gene name)
Genetic variants : HAPMAP9180
Genomic Variants (DGV)OSMR [DGVbeta]
DECIPHEROSMR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOSMR 
Mutations
ICGC Data PortalOSMR 
TCGA Data PortalOSMR 
Broad Tumor PortalOSMR
OASIS PortalOSMR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOSMR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOSMR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OSMR
DgiDB (Drug Gene Interaction Database)OSMR
DoCM (Curated mutations)OSMR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OSMR (select a term)
intoGenOSMR
Cancer3DOSMR(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM105250    601743   
Orphanet22120   
MedgenOSMR
Genetic Testing Registry OSMR
NextProtQ99650 [Medical]
TSGene9180
GENETestsOSMR
Target ValidationOSMR
Huge Navigator OSMR [HugePedia]
snp3D : Map Gene to Disease9180
BioCentury BCIQOSMR
ClinGenOSMR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9180
Chemical/Pharm GKB GenePA32837
Clinical trialOSMR
Miscellaneous
canSAR (ICR)OSMR (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOSMR
EVEXOSMR
GoPubMedOSMR
iHOPOSMR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:09:48 CEST 2017

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