Atlas of Genetics and Cytogenetics in Oncology and Haematology

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OSTF1 (osteoclast stimulating factor 1)

Identity

Alias_symbol (synonym)SH3P2
OSF
bA235O14.1
Other alias
HGNC (Hugo) OSTF1
LocusID (NCBI) 26578
Atlas_Id 56037
Location 9q21.13  [Link to chromosome band 9q21]
Location_base_pair Starts at 75088482 and ends at 75147198 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC117 (22q12.1) / OSTF1 (9q21.13)OSTF1 (9q21.13) / SYNE2 (14q23.2)PCSK5 (9q21.13) / OSTF1 (9q21.13)
RASEF (9q21.32) / OSTF1 (9q21.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(9;9)(q21;q21) PCSK5/OSTF1
t(9;9)(q21;q21) RASEF/OSTF1
t(9;22)(q21;q12) CCDC117/OSTF1

External links

Nomenclature
HGNC (Hugo)OSTF1   8510
Cards
Entrez_Gene (NCBI)OSTF1  26578  osteoclast stimulating factor 1
AliasesOSF; SH3P2; bA235O14.1
GeneCards (Weizmann)OSTF1
Ensembl hg19 (Hinxton)ENSG00000134996 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134996 [Gene_View]  chr9:75088482-75147198 [Contig_View]  OSTF1 [Vega]
ICGC DataPortalENSG00000134996
TCGA cBioPortalOSTF1
AceView (NCBI)OSTF1
Genatlas (Paris)OSTF1
WikiGenes26578
SOURCE (Princeton)OSTF1
Genetics Home Reference (NIH)OSTF1
Genomic and cartography
GoldenPath hg38 (UCSC)OSTF1  -     chr9:75088482-75147198 +  9q21.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OSTF1  -     9q21.13   [Description]    (hg19-Feb_2009)
EnsemblOSTF1 - 9q21.13 [CytoView hg19]  OSTF1 - 9q21.13 [CytoView hg38]
Mapping of homologs : NCBIOSTF1 [Mapview hg19]  OSTF1 [Mapview hg38]
OMIM610180   
Gene and transcription
Genbank (Entrez)AK222596 AK291511 BC007459 BP312980 U63717
RefSeq transcript (Entrez)NM_012383
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OSTF1
Cluster EST : UnigeneHs.494192 [ NCBI ]
CGAP (NCI)Hs.494192
Alternative Splicing GalleryENSG00000134996
Gene ExpressionOSTF1 [ NCBI-GEO ]   OSTF1 [ EBI - ARRAY_EXPRESS ]   OSTF1 [ SEEK ]   OSTF1 [ MEM ]
Gene Expression Viewer (FireBrowse)OSTF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26578
GTEX Portal (Tissue expression)OSTF1
Human Protein AtlasENSG00000134996-OSTF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92882   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92882  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92882
Splice isoforms : SwissVarQ92882
PhosPhoSitePlusQ92882
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    SH3 (PS50002)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    SH3_domain   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam12796    pfam00018   
Domain families : Smart (EMBL)ANK (SM00248)  SH3 (SM00326)  
Conserved Domain (NCBI)OSTF1
DMDM Disease mutations26578
Blocks (Seattle)OSTF1
PDB (SRS)1X2K    1ZLM    3EHQ    3EHR   
PDB (PDBSum)1X2K    1ZLM    3EHQ    3EHR   
PDB (IMB)1X2K    1ZLM    3EHQ    3EHR   
PDB (RSDB)1X2K    1ZLM    3EHQ    3EHR   
Structural Biology KnowledgeBase1X2K    1ZLM    3EHQ    3EHR   
SCOP (Structural Classification of Proteins)1X2K    1ZLM    3EHQ    3EHR   
CATH (Classification of proteins structures)1X2K    1ZLM    3EHQ    3EHR   
SuperfamilyQ92882
Human Protein Atlas [tissue]ENSG00000134996-OSTF1 [tissue]
Peptide AtlasQ92882
HPRD17808
IPIIPI00414836   
Protein Interaction databases
DIP (DOE-UCLA)Q92882
IntAct (EBI)Q92882
FunCoupENSG00000134996
BioGRIDOSTF1
STRING (EMBL)OSTF1
ZODIACOSTF1
Ontologies - Pathways
QuickGOQ92882
Ontology : AmiGOossification  protein binding  extracellular region  extracellular region  intracellular  signal transduction  SH3 domain binding  secretory granule lumen  neutrophil degranulation  extracellular exosome  ficolin-1-rich granule lumen  
Ontology : EGO-EBIossification  protein binding  extracellular region  extracellular region  intracellular  signal transduction  SH3 domain binding  secretory granule lumen  neutrophil degranulation  extracellular exosome  ficolin-1-rich granule lumen  
NDEx NetworkOSTF1
Atlas of Cancer Signalling NetworkOSTF1
Wikipedia pathwaysOSTF1
Orthology - Evolution
OrthoDB26578
GeneTree (enSembl)ENSG00000134996
Phylogenetic Trees/Animal Genes : TreeFamOSTF1
HOVERGENQ92882
HOGENOMQ92882
Homologs : HomoloGeneOSTF1
Homology/Alignments : Family Browser (UCSC)OSTF1
Gene fusions - Rearrangements
Fusion : QuiverOSTF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOSTF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OSTF1
dbVarOSTF1
ClinVarOSTF1
1000_GenomesOSTF1 
Exome Variant ServerOSTF1
ExAC (Exome Aggregation Consortium)ENSG00000134996
GNOMAD BrowserENSG00000134996
Genetic variants : HAPMAP26578
Genomic Variants (DGV)OSTF1 [DGVbeta]
DECIPHEROSTF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOSTF1 
Mutations
ICGC Data PortalOSTF1 
TCGA Data PortalOSTF1 
Broad Tumor PortalOSTF1
OASIS PortalOSTF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOSTF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOSTF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OSTF1
DgiDB (Drug Gene Interaction Database)OSTF1
DoCM (Curated mutations)OSTF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OSTF1 (select a term)
intoGenOSTF1
Cancer3DOSTF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610180   
Orphanet
DisGeNETOSTF1
MedgenOSTF1
Genetic Testing Registry OSTF1
NextProtQ92882 [Medical]
TSGene26578
GENETestsOSTF1
Target ValidationOSTF1
Huge Navigator OSTF1 [HugePedia]
snp3D : Map Gene to Disease26578
BioCentury BCIQOSTF1
ClinGenOSTF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26578
Chemical/Pharm GKB GenePA32839
Clinical trialOSTF1
Miscellaneous
canSAR (ICR)OSTF1 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOSTF1
EVEXOSTF1
GoPubMedOSTF1
iHOPOSTF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:29:05 CET 2018
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