Atlas of Genetics and Cytogenetics in Oncology and Haematology

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OTOL1 (otolin 1)

Identity

Alias_namesotolin 1 homolog (zebrafish)
Alias_symbol (synonym)C1QTNF15
Other aliasC1QTNF16
HGNC (Hugo) OTOL1
LocusID (NCBI) 131149
Atlas_Id 54521
Location 3q26.1  [Link to chromosome band 3q26]
Location_base_pair Starts at 161496808 and ends at 161503942 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HLTF (3q24) / OTOL1 (3q26.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(3;3)(q24;q26) HLTF/OTOL1

External links

Nomenclature
HGNC (Hugo)OTOL1   34071
Cards
Entrez_Gene (NCBI)OTOL1  131149  otolin 1
AliasesC1QTNF15; C1QTNF16
GeneCards (Weizmann)OTOL1
Ensembl hg19 (Hinxton)ENSG00000182447 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182447 [Gene_View]  ENSG00000182447 [Sequence]  chr3:161496808-161503942 [Contig_View]  OTOL1 [Vega]
ICGC DataPortalENSG00000182447
TCGA cBioPortalOTOL1
AceView (NCBI)OTOL1
Genatlas (Paris)OTOL1
WikiGenes131149
SOURCE (Princeton)OTOL1
Genetics Home Reference (NIH)OTOL1
Genomic and cartography
GoldenPath hg38 (UCSC)OTOL1  -     chr3:161496808-161503942 +  3q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OTOL1  -     3q26.1   [Description]    (hg19-Feb_2009)
GoldenPathOTOL1 - 3q26.1 [CytoView hg19]  OTOL1 - 3q26.1 [CytoView hg38]
ImmunoBaseENSG00000182447
Mapping of homologs : NCBIOTOL1 [Mapview hg19]  OTOL1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_001080440
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OTOL1
Cluster EST : UnigeneHs.585021 [ NCBI ]
CGAP (NCI)Hs.585021
Alternative Splicing GalleryENSG00000182447
Gene ExpressionOTOL1 [ NCBI-GEO ]   OTOL1 [ EBI - ARRAY_EXPRESS ]   OTOL1 [ SEEK ]   OTOL1 [ MEM ]
Gene Expression Viewer (FireBrowse)OTOL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)131149
GTEX Portal (Tissue expression)OTOL1
Human Protein AtlasENSG00000182447-OTOL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA6NHN0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA6NHN0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA6NHN0
Splice isoforms : SwissVarA6NHN0
PhosPhoSitePlusA6NHN0
Domaine pattern : Prosite (Expaxy)C1Q (PS50871)   
Domains : Interpro (EBI)C1q_dom    Collagen    Tumour_necrosis_fac-like_dom   
Domain families : Pfam (Sanger)C1q (PF00386)    Collagen (PF01391)   
Domain families : Pfam (NCBI)pfam00386    pfam01391   
Domain families : Smart (EMBL)C1Q (SM00110)  
Conserved Domain (NCBI)OTOL1
DMDM Disease mutations131149
Blocks (Seattle)OTOL1
SuperfamilyA6NHN0
Human Protein Atlas [tissue]ENSG00000182447-OTOL1 [tissue]
Peptide AtlasA6NHN0
IPIIPI00477692   
Protein Interaction databases
DIP (DOE-UCLA)A6NHN0
IntAct (EBI)A6NHN0
FunCoupENSG00000182447
BioGRIDOTOL1
STRING (EMBL)OTOL1
ZODIACOTOL1
Ontologies - Pathways
QuickGOA6NHN0
Ontology : AmiGOextracellular matrix structural constituent  calcium ion binding  extracellular region  collagen trimer  extracellular space  extracellular matrix organization  extracellular matrix  otolith mineralization  protein homooligomerization  
Ontology : EGO-EBIextracellular matrix structural constituent  calcium ion binding  extracellular region  collagen trimer  extracellular space  extracellular matrix organization  extracellular matrix  otolith mineralization  protein homooligomerization  
NDEx NetworkOTOL1
Atlas of Cancer Signalling NetworkOTOL1
Wikipedia pathwaysOTOL1
Orthology - Evolution
OrthoDB131149
GeneTree (enSembl)ENSG00000182447
Phylogenetic Trees/Animal Genes : TreeFamOTOL1
HOGENOMA6NHN0
Homologs : HomoloGeneOTOL1
Homology/Alignments : Family Browser (UCSC)OTOL1
Gene fusions - Rearrangements
Fusion : MitelmanHLTF/OTOL1 [3q24/3q26.1]  [t(3;3)(q24;q26)]  
Fusion : QuiverOTOL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOTOL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OTOL1
dbVarOTOL1
ClinVarOTOL1
1000_GenomesOTOL1 
Exome Variant ServerOTOL1
ExAC (Exome Aggregation Consortium)ENSG00000182447
GNOMAD BrowserENSG00000182447
Varsome BrowserOTOL1
Genetic variants : HAPMAP131149
Genomic Variants (DGV)OTOL1 [DGVbeta]
DECIPHEROTOL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOTOL1 
Mutations
ICGC Data PortalOTOL1 
TCGA Data PortalOTOL1 
Broad Tumor PortalOTOL1
OASIS PortalOTOL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOTOL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOTOL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OTOL1
DgiDB (Drug Gene Interaction Database)OTOL1
DoCM (Curated mutations)OTOL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OTOL1 (select a term)
intoGenOTOL1
Cancer3DOTOL1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETOTOL1
MedgenOTOL1
Genetic Testing Registry OTOL1
NextProtA6NHN0 [Medical]
TSGene131149
GENETestsOTOL1
Target ValidationOTOL1
Huge Navigator OTOL1 [HugePedia]
snp3D : Map Gene to Disease131149
BioCentury BCIQOTOL1
ClinGenOTOL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD131149
Chemical/Pharm GKB GenePA166049016
Clinical trialOTOL1
Miscellaneous
canSAR (ICR)OTOL1 (select the gene name)
DataMed IndexOTOL1
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOTOL1
EVEXOTOL1
GoPubMedOTOL1
iHOPOTOL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 7 18:12:00 CEST 2019
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