OTOS (otospiralin)

2014-11-01  

Identity

HGNC
OTOS
LOCATION
2q37.3
LOCUSID
150677
ALIAS
OTOSP

Other Information

Locus ID:

NCBI: 150677
MIM: 607877
HGNC: 22644
Ensembl: ENSG00000178602

Variants:

dbSNP: 150677
ClinVar: 150677
TCGA: ENSG00000178602
COSMIC: OTOS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178602ENST00000319460Q8NHW6
ENSG00000178602ENST00000391989Q8NHW6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD25410892, 31666714
PA449014cisplatinChemicalClinicalAnnotationassociatedPD25410892, 31666714

References

Pubmed IDYearTitleCitations
254108922014Genetic variation in Otos is associated with cisplatin-induced ototoxicity.6
126874212003Gene structure, chromosomal localization, and mutation screening of the human gene for the inner ear protein otospiralin.1

Citation

Dessen P

OTOS (otospiralin)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71579/otos