OTP (orthopedia homeobox)

2012-08-01  

Identity

HGNC
OTP
LOCATION
5q14.1
LOCUSID
23440
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23440
MIM: 604529
HGNC: 8518
Ensembl: ENSG00000171540

Variants:

dbSNP: 23440
ClinVar: 23440
TCGA: ENSG00000171540
COSMIC: OTP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171540ENST00000306422Q5XKR4

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
hypothalamus
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
234442222013CD44 and OTP are strong prognostic markers for pulmonary carcinoids.12
223669912012Genome-wide identification of OTP gene as a novel methylation marker of breast cancer.6
269278882016Diagnostic Utility of Orthopedia Homeobox (OTP) in Pulmonary Carcinoid Tumors.4
293163262018Orthopedia homeobox is preferentially expressed in typical carcinoids of the lung.2
291072892017Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety.1
302844102018Immunohistochemical analysis of OTP and NKX6.1 in neuroendocrine tumors of the lung and pancreas.1

Citation

Dessen P

OTP (orthopedia homeobox)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52842/otp