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OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1)

Identity

Alias_namesOTU domain
Alias_symbol (synonym)FLJ20113
FLJ40710
Other aliasHSPC263
OTB1
OTU1
HGNC (Hugo) OTUB1
LocusID (NCBI) 55611
Atlas_Id 41619
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 63985853 and ends at 63998420 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LOC100507412 (-) / OTUB1 (11q13.1)OTUB1 (11q13.1) / COX8A (11q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OTUB1   23077
Cards
Entrez_Gene (NCBI)OTUB1  55611  OTU deubiquitinase, ubiquitin aldehyde binding 1
AliasesHSPC263; OTB1; OTU1
GeneCards (Weizmann)OTUB1
Ensembl hg19 (Hinxton)ENSG00000167770 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167770 [Gene_View]  chr11:63985853-63998420 [Contig_View]  OTUB1 [Vega]
ICGC DataPortalENSG00000167770
TCGA cBioPortalOTUB1
AceView (NCBI)OTUB1
Genatlas (Paris)OTUB1
WikiGenes55611
SOURCE (Princeton)OTUB1
Genetics Home Reference (NIH)OTUB1
Genomic and cartography
GoldenPath hg38 (UCSC)OTUB1  -     chr11:63985853-63998420 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OTUB1  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblOTUB1 - 11q13.1 [CytoView hg19]  OTUB1 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIOTUB1 [Mapview hg19]  OTUB1 [Mapview hg38]
OMIM608337   
Gene and transcription
Genbank (Entrez)AF161381 AK000120 AK091830 AK098029 AK225133
RefSeq transcript (Entrez)NM_017670
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OTUB1
Cluster EST : UnigeneHs.473788 [ NCBI ]
CGAP (NCI)Hs.473788
Alternative Splicing GalleryENSG00000167770
Gene ExpressionOTUB1 [ NCBI-GEO ]   OTUB1 [ EBI - ARRAY_EXPRESS ]   OTUB1 [ SEEK ]   OTUB1 [ MEM ]
Gene Expression Viewer (FireBrowse)OTUB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55611
GTEX Portal (Tissue expression)OTUB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96FW1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96FW1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96FW1
Splice isoforms : SwissVarQ96FW1
PhosPhoSitePlusQ96FW1
Domaine pattern : Prosite (Expaxy)OTU (PS50802)   
Domains : Interpro (EBI)OTU_dom    OTUB1    Otubain    Peptidase_C65_otubain   
Domain families : Pfam (Sanger)Peptidase_C65 (PF10275)   
Domain families : Pfam (NCBI)pfam10275   
Conserved Domain (NCBI)OTUB1
DMDM Disease mutations55611
Blocks (Seattle)OTUB1
PDB (SRS)2ZFY    3VON    4DDG    4DDI    4DHZ    4I6L    4LDT   
PDB (PDBSum)2ZFY    3VON    4DDG    4DDI    4DHZ    4I6L    4LDT   
PDB (IMB)2ZFY    3VON    4DDG    4DDI    4DHZ    4I6L    4LDT   
PDB (RSDB)2ZFY    3VON    4DDG    4DDI    4DHZ    4I6L    4LDT   
Structural Biology KnowledgeBase2ZFY    3VON    4DDG    4DDI    4DHZ    4I6L    4LDT   
SCOP (Structural Classification of Proteins)2ZFY    3VON    4DDG    4DDI    4DHZ    4I6L    4LDT   
CATH (Classification of proteins structures)2ZFY    3VON    4DDG    4DDI    4DHZ    4I6L    4LDT   
SuperfamilyQ96FW1
Human Protein AtlasENSG00000167770
Peptide AtlasQ96FW1
HPRD08493
IPIIPI00939174   IPI00409750   IPI00000581   IPI01011145   IPI01014215   IPI01012383   IPI01011961   
Protein Interaction databases
DIP (DOE-UCLA)Q96FW1
IntAct (EBI)Q96FW1
FunCoupENSG00000167770
BioGRIDOTUB1
STRING (EMBL)OTUB1
ZODIACOTUB1
Ontologies - Pathways
QuickGOQ96FW1
Ontology : AmiGOadaptive immune response  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  nucleoplasm  cytosol  DNA repair  cellular response to DNA damage stimulus  protein deubiquitination  NEDD8-specific protease activity  ubiquitin protein ligase binding  ubiquitin binding  extracellular exosome  protein K48-linked deubiquitination  cellular response to interleukin-1  negative regulation of histone H2A K63-linked ubiquitination  negative regulation of double-strand break repair  
Ontology : EGO-EBIadaptive immune response  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  nucleoplasm  cytosol  DNA repair  cellular response to DNA damage stimulus  protein deubiquitination  NEDD8-specific protease activity  ubiquitin protein ligase binding  ubiquitin binding  extracellular exosome  protein K48-linked deubiquitination  cellular response to interleukin-1  negative regulation of histone H2A K63-linked ubiquitination  negative regulation of double-strand break repair  
NDEx NetworkOTUB1
Atlas of Cancer Signalling NetworkOTUB1
Wikipedia pathwaysOTUB1
Orthology - Evolution
OrthoDB55611
GeneTree (enSembl)ENSG00000167770
Phylogenetic Trees/Animal Genes : TreeFamOTUB1
HOVERGENQ96FW1
HOGENOMQ96FW1
Homologs : HomoloGeneOTUB1
Homology/Alignments : Family Browser (UCSC)OTUB1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOTUB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OTUB1
dbVarOTUB1
ClinVarOTUB1
1000_GenomesOTUB1 
Exome Variant ServerOTUB1
ExAC (Exome Aggregation Consortium)OTUB1 (select the gene name)
Genetic variants : HAPMAP55611
Genomic Variants (DGV)OTUB1 [DGVbeta]
DECIPHEROTUB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOTUB1 
Mutations
ICGC Data PortalOTUB1 
TCGA Data PortalOTUB1 
Broad Tumor PortalOTUB1
OASIS PortalOTUB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOTUB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOTUB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OTUB1
DgiDB (Drug Gene Interaction Database)OTUB1
DoCM (Curated mutations)OTUB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OTUB1 (select a term)
intoGenOTUB1
Cancer3DOTUB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608337   
Orphanet
MedgenOTUB1
Genetic Testing Registry OTUB1
NextProtQ96FW1 [Medical]
TSGene55611
GENETestsOTUB1
Target ValidationOTUB1
Huge Navigator OTUB1 [HugePedia]
snp3D : Map Gene to Disease55611
BioCentury BCIQOTUB1
ClinGenOTUB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55611
Chemical/Pharm GKB GenePA134988141
Clinical trialOTUB1
Miscellaneous
canSAR (ICR)OTUB1 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOTUB1
EVEXOTUB1
GoPubMedOTUB1
iHOPOTUB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:09:50 CEST 2017

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