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OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2)

Identity

Alias_namesC14orf137
chromosome 14 open reading frame 137
OTU domain, ubiquitin aldehyde binding 2
Alias_symbol (synonym)FLJ21916
MGC3102
Other aliasOTB2
OTU2
HGNC (Hugo) OTUB2
LocusID (NCBI) 78990
Atlas_Id 865
Location 14q32.12  [Link to chromosome band 14q32]
Location_base_pair Starts at 94026378 and ends at 94048930 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLEC16A (16p13.13) / OTUB2 (14q32.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OTUB2   20351
Cards
Entrez_Gene (NCBI)OTUB2  78990  OTU deubiquitinase, ubiquitin aldehyde binding 2
AliasesC14orf137; OTB2; OTU2
GeneCards (Weizmann)OTUB2
Ensembl hg19 (Hinxton)ENSG00000089723 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000089723 [Gene_View]  chr14:94026378-94048930 [Contig_View]  OTUB2 [Vega]
ICGC DataPortalENSG00000089723
TCGA cBioPortalOTUB2
AceView (NCBI)OTUB2
Genatlas (Paris)OTUB2
WikiGenes78990
SOURCE (Princeton)OTUB2
Genetics Home Reference (NIH)OTUB2
Genomic and cartography
GoldenPath hg38 (UCSC)OTUB2  -     chr14:94026378-94048930 +  14q32.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OTUB2  -     14q32.12   [Description]    (hg19-Feb_2009)
EnsemblOTUB2 - 14q32.12 [CytoView hg19]  OTUB2 - 14q32.12 [CytoView hg38]
Mapping of homologs : NCBIOTUB2 [Mapview hg19]  OTUB2 [Mapview hg38]
OMIM608338   
Gene and transcription
Genbank (Entrez)AF318378 AI018242 AK025569 AY177201 BC000208
RefSeq transcript (Entrez)NM_023112
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_187601
Consensus coding sequences : CCDS (NCBI)OTUB2
Cluster EST : UnigeneHs.278815 [ NCBI ]
CGAP (NCI)Hs.278815
Alternative Splicing GalleryENSG00000089723
Gene ExpressionOTUB2 [ NCBI-GEO ]   OTUB2 [ EBI - ARRAY_EXPRESS ]   OTUB2 [ SEEK ]   OTUB2 [ MEM ]
Gene Expression Viewer (FireBrowse)OTUB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)78990
GTEX Portal (Tissue expression)OTUB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96DC9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96DC9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96DC9
Splice isoforms : SwissVarQ96DC9
PhosPhoSitePlusQ96DC9
Domaine pattern : Prosite (Expaxy)OTU (PS50802)   
Domains : Interpro (EBI)OTU_dom    OTUB2    Otubain    Peptidase_C65_otubain   
Domain families : Pfam (Sanger)Peptidase_C65 (PF10275)   
Domain families : Pfam (NCBI)pfam10275   
Conserved Domain (NCBI)OTUB2
DMDM Disease mutations78990
Blocks (Seattle)OTUB2
PDB (SRS)1TFF    4FJV   
PDB (PDBSum)1TFF    4FJV   
PDB (IMB)1TFF    4FJV   
PDB (RSDB)1TFF    4FJV   
Structural Biology KnowledgeBase1TFF    4FJV   
SCOP (Structural Classification of Proteins)1TFF    4FJV   
CATH (Classification of proteins structures)1TFF    4FJV   
SuperfamilyQ96DC9
Human Protein AtlasENSG00000089723
Peptide AtlasQ96DC9
HPRD07620
IPIIPI00302895   IPI00401454   IPI00103793   IPI00386882   
Protein Interaction databases
DIP (DOE-UCLA)Q96DC9
IntAct (EBI)Q96DC9
FunCoupENSG00000089723
BioGRIDOTUB2
STRING (EMBL)OTUB2
ZODIACOTUB2
Ontologies - Pathways
QuickGOQ96DC9
Ontology : AmiGOthiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  protein deubiquitination  NEDD8-specific protease activity  protein K11-linked deubiquitination  ubiquitin binding  protein K63-linked deubiquitination  protein K48-linked deubiquitination  
Ontology : EGO-EBIthiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  protein deubiquitination  NEDD8-specific protease activity  protein K11-linked deubiquitination  ubiquitin binding  protein K63-linked deubiquitination  protein K48-linked deubiquitination  
NDEx NetworkOTUB2
Atlas of Cancer Signalling NetworkOTUB2
Wikipedia pathwaysOTUB2
Orthology - Evolution
OrthoDB78990
GeneTree (enSembl)ENSG00000089723
Phylogenetic Trees/Animal Genes : TreeFamOTUB2
HOVERGENQ96DC9
HOGENOMQ96DC9
Homologs : HomoloGeneOTUB2
Homology/Alignments : Family Browser (UCSC)OTUB2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOTUB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OTUB2
dbVarOTUB2
ClinVarOTUB2
1000_GenomesOTUB2 
Exome Variant ServerOTUB2
ExAC (Exome Aggregation Consortium)OTUB2 (select the gene name)
Genetic variants : HAPMAP78990
Genomic Variants (DGV)OTUB2 [DGVbeta]
DECIPHEROTUB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOTUB2 
Mutations
ICGC Data PortalOTUB2 
TCGA Data PortalOTUB2 
Broad Tumor PortalOTUB2
OASIS PortalOTUB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOTUB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOTUB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OTUB2
DgiDB (Drug Gene Interaction Database)OTUB2
DoCM (Curated mutations)OTUB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OTUB2 (select a term)
intoGenOTUB2
Cancer3DOTUB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608338   
Orphanet
MedgenOTUB2
Genetic Testing Registry OTUB2
NextProtQ96DC9 [Medical]
TSGene78990
GENETestsOTUB2
Target ValidationOTUB2
Huge Navigator OTUB2 [HugePedia]
snp3D : Map Gene to Disease78990
BioCentury BCIQOTUB2
ClinGenOTUB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD78990
Chemical/Pharm GKB GenePA134861658
Clinical trialOTUB2
Miscellaneous
canSAR (ICR)OTUB2 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOTUB2
EVEXOTUB2
GoPubMedOTUB2
iHOPOTUB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:48:08 CEST 2017

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