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OTUD4 (OTU deubiquitinase 4)

Identity

Alias_namesOTU domain containing 4
Alias_symbol (synonym)HSHIN1
KIAA1046
DUBA6
Other aliasHIN1
HGNC (Hugo) OTUD4
LocusID (NCBI) 54726
Atlas_Id 55390
Location 4q31.21  [Link to chromosome band 4q31]
Location_base_pair Starts at 145133650 and ends at 145179680 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANAPC10 (4q31.21) / OTUD4 (4q31.21)OTUD4 (4q31.21) / OTUD4 (4q31.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OTUD4   24949
Cards
Entrez_Gene (NCBI)OTUD4  54726  OTU deubiquitinase 4
AliasesDUBA6; HIN1; HSHIN1
GeneCards (Weizmann)OTUD4
Ensembl hg19 (Hinxton)ENSG00000164164 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164164 [Gene_View]  chr4:145133650-145179680 [Contig_View]  OTUD4 [Vega]
ICGC DataPortalENSG00000164164
TCGA cBioPortalOTUD4
AceView (NCBI)OTUD4
Genatlas (Paris)OTUD4
WikiGenes54726
SOURCE (Princeton)OTUD4
Genetics Home Reference (NIH)OTUD4
Genomic and cartography
GoldenPath hg38 (UCSC)OTUD4  -     chr4:145133650-145179680 -  4q31.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OTUD4  -     4q31.21   [Description]    (hg19-Feb_2009)
EnsemblOTUD4 - 4q31.21 [CytoView hg19]  OTUD4 - 4q31.21 [CytoView hg38]
Mapping of homologs : NCBIOTUD4 [Mapview hg19]  OTUD4 [Mapview hg38]
OMIM611744   
Gene and transcription
Genbank (Entrez)AB028969 AK056597 AK302581 AL137460 AU139986
RefSeq transcript (Entrez)NM_001102653 NM_017493 NM_199324
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OTUD4
Cluster EST : UnigeneHs.270851 [ NCBI ]
CGAP (NCI)Hs.270851
Alternative Splicing GalleryENSG00000164164
Gene ExpressionOTUD4 [ NCBI-GEO ]   OTUD4 [ EBI - ARRAY_EXPRESS ]   OTUD4 [ SEEK ]   OTUD4 [ MEM ]
Gene Expression Viewer (FireBrowse)OTUD4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54726
GTEX Portal (Tissue expression)OTUD4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01804   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01804  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01804
Splice isoforms : SwissVarQ01804
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusQ01804
Domaine pattern : Prosite (Expaxy)OTU (PS50802)   
Domains : Interpro (EBI)OTU_dom   
Domain families : Pfam (Sanger)OTU (PF02338)   
Domain families : Pfam (NCBI)pfam02338   
Conserved Domain (NCBI)OTUD4
DMDM Disease mutations54726
Blocks (Seattle)OTUD4
SuperfamilyQ01804
Human Protein AtlasENSG00000164164
Peptide AtlasQ01804
HPRD11033
IPIIPI00009780   IPI00969056   IPI00969366   IPI00939825   IPI00399254   IPI00965638   
Protein Interaction databases
DIP (DOE-UCLA)Q01804
IntAct (EBI)Q01804
FunCoupENSG00000164164
BioGRIDOTUD4
STRING (EMBL)OTUD4
ZODIACOTUD4
Ontologies - Pathways
QuickGOQ01804
Ontology : AmiGORNA binding  thiol-dependent ubiquitin-specific protease activity  protein binding  cellular_component  protein K48-linked deubiquitination  
Ontology : EGO-EBIRNA binding  thiol-dependent ubiquitin-specific protease activity  protein binding  cellular_component  protein K48-linked deubiquitination  
NDEx NetworkOTUD4
Atlas of Cancer Signalling NetworkOTUD4
Wikipedia pathwaysOTUD4
Orthology - Evolution
OrthoDB54726
GeneTree (enSembl)ENSG00000164164
Phylogenetic Trees/Animal Genes : TreeFamOTUD4
HOVERGENQ01804
HOGENOMQ01804
Homologs : HomoloGeneOTUD4
Homology/Alignments : Family Browser (UCSC)OTUD4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOTUD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OTUD4
dbVarOTUD4
ClinVarOTUD4
1000_GenomesOTUD4 
Exome Variant ServerOTUD4
ExAC (Exome Aggregation Consortium)OTUD4 (select the gene name)
Genetic variants : HAPMAP54726
Genomic Variants (DGV)OTUD4 [DGVbeta]
DECIPHEROTUD4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOTUD4 
Mutations
ICGC Data PortalOTUD4 
TCGA Data PortalOTUD4 
Broad Tumor PortalOTUD4
OASIS PortalOTUD4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOTUD4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOTUD4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OTUD4
DgiDB (Drug Gene Interaction Database)OTUD4
DoCM (Curated mutations)OTUD4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OTUD4 (select a term)
intoGenOTUD4
Cancer3DOTUD4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611744   
Orphanet
MedgenOTUD4
Genetic Testing Registry OTUD4
NextProtQ01804 [Medical]
TSGene54726
GENETestsOTUD4
Huge Navigator OTUD4 [HugePedia]
snp3D : Map Gene to Disease54726
BioCentury BCIQOTUD4
ClinGenOTUD4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54726
Chemical/Pharm GKB GenePA142671216
Clinical trialOTUD4
Miscellaneous
canSAR (ICR)OTUD4 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOTUD4
EVEXOTUD4
GoPubMedOTUD4
iHOPOTUD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:29:53 CEST 2017

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