OTUD5 (OTU deubiquitinase 5)

2021-06-01  

Identity

HGNC
OTUD5
LOCATION
Xp11.23
LOCUSID
55593
ALIAS
DUBA,MCAND

Other Information

Locus ID:

NCBI: 55593
MIM: 300713
HGNC: 25402
Ensembl: ENSG00000068308

Variants:

dbSNP: 55593
ClinVar: 55593
TCGA: ENSG00000068308
COSMIC: OTUD5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000068308ENST00000156084Q96G74
ENSG00000068308ENST00000156084A0A024QZ09
ENSG00000068308ENST00000376488Q96G74
ENSG00000068308ENST00000396743Q96G74
ENSG00000068308ENST00000428668Q96G74
ENSG00000068308ENST00000455452H7BZQ3
ENSG00000068308ENST00000610466A0A087WXV6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
DeubiquitinationREACTOMER-HSA-5688426
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
179918292007DUBA: a deubiquitinase that regulates type I interferon production.178
222459692012Phosphorylation-dependent activity of the deubiquitinase DUBA.34
241432562013OTUD5 regulates p53 stability by deubiquitinating p53.13
254990822015Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress.12
305081132019The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin.5
309801122019The deubiquitinase OTUD5 regulates Ku80 stability and non-homologous end joining.1

Citation

Dessen P

OTUD5 (OTU deubiquitinase 5)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58331/otud5