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OTUD5 (OTU deubiquitinase 5)

Identity

Alias_namesOTU domain containing 5
Alias_symbol (synonym)DKFZp761A052
DUBA
Other alias
HGNC (Hugo) OTUD5
LocusID (NCBI) 55593
Atlas_Id 71582
Location Xp11.23  [Link to chromosome band Xp11]
Location_base_pair Starts at 48779303 and ends at 48814893 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CHD2 (15q26.1) / OTUD5 (Xp11.23)MYT1L (2p25.3) / OTUD5 (Xp11.23)NCOR2 (12q24.31) / OTUD5 (Xp11.23)
OTUD5 (Xp11.23) / CHTOP (1q21.3)OTUD5 (Xp11.23) / ZBTB44 (11q24.3)ST14 (11q24.3) / OTUD5 (Xp11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OTUD5   25402
Cards
Entrez_Gene (NCBI)OTUD5  55593  OTU deubiquitinase 5
AliasesDUBA
GeneCards (Weizmann)OTUD5
Ensembl hg19 (Hinxton)ENSG00000068308 [Gene_View]  chrX:48779303-48814893 [Contig_View]  OTUD5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000068308 [Gene_View]  chrX:48779303-48814893 [Contig_View]  OTUD5 [Vega]
ICGC DataPortalENSG00000068308
TCGA cBioPortalOTUD5
AceView (NCBI)OTUD5
Genatlas (Paris)OTUD5
WikiGenes55593
SOURCE (Princeton)OTUD5
Genetics Home Reference (NIH)OTUD5
Genomic and cartography
GoldenPath hg19 (UCSC)OTUD5  -     chrX:48779303-48814893 -  Xp11.23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)OTUD5  -     Xp11.23   [Description]    (hg38-Dec_2013)
EnsemblOTUD5 - Xp11.23 [CytoView hg19]  OTUD5 - Xp11.23 [CytoView hg38]
Mapping of homologs : NCBIOTUD5 [Mapview hg19]  OTUD5 [Mapview hg38]
OMIM300713   
Gene and transcription
Genbank (Entrez)AK022612 AK026260 AK294590 AL137509 BC009917
RefSeq transcript (Entrez)NM_001136157 NM_001136158 NM_001136159 NM_017602
RefSeq genomic (Entrez)NC_000023 NC_018934 NT_079573 NW_004929439
Consensus coding sequences : CCDS (NCBI)OTUD5
Cluster EST : UnigeneHs.496098 [ NCBI ]
CGAP (NCI)Hs.496098
Alternative Splicing GalleryENSG00000068308
Gene ExpressionOTUD5 [ NCBI-GEO ]   OTUD5 [ EBI - ARRAY_EXPRESS ]   OTUD5 [ SEEK ]   OTUD5 [ MEM ]
Gene Expression Viewer (FireBrowse)OTUD5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55593
GTEX Portal (Tissue expression)OTUD5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96G74   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96G74  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96G74
Splice isoforms : SwissVarQ96G74
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusQ96G74
Domaine pattern : Prosite (Expaxy)OTU (PS50802)   
Domains : Interpro (EBI)OTU   
Domain families : Pfam (Sanger)OTU (PF02338)   
Domain families : Pfam (NCBI)pfam02338   
Conserved Domain (NCBI)OTUD5
DMDM Disease mutations55593
Blocks (Seattle)OTUD5
PDB (SRS)3PFY    3TMO    3TMP   
PDB (PDBSum)3PFY    3TMO    3TMP   
PDB (IMB)3PFY    3TMO    3TMP   
PDB (RSDB)3PFY    3TMO    3TMP   
Structural Biology KnowledgeBase3PFY    3TMO    3TMP   
SCOP (Structural Classification of Proteins)3PFY    3TMO    3TMP   
CATH (Classification of proteins structures)3PFY    3TMO    3TMP   
SuperfamilyQ96G74
Human Protein AtlasENSG00000068308
Peptide AtlasQ96G74
HPRD06488
IPIIPI00640364   IPI00940013   IPI00062321   IPI00641956   IPI01013064   
Protein Interaction databases
DIP (DOE-UCLA)Q96G74
IntAct (EBI)Q96G74
FunCoupENSG00000068308
BioGRIDOTUD5
STRING (EMBL)OTUD5
ZODIACOTUD5
Ontologies - Pathways
QuickGOQ96G74
Ontology : AmiGOubiquitin-specific protease activity  cytosol  negative regulation of type I interferon production  response to lipopolysaccharide  innate immune response  protein K63-linked deubiquitination  protein K48-linked deubiquitination  
Ontology : EGO-EBIubiquitin-specific protease activity  cytosol  negative regulation of type I interferon production  response to lipopolysaccharide  innate immune response  protein K63-linked deubiquitination  protein K48-linked deubiquitination  
Pathways : KEGGRIG-I-like receptor signaling pathway   
NDEx NetworkOTUD5
Atlas of Cancer Signalling NetworkOTUD5
Wikipedia pathwaysOTUD5
Orthology - Evolution
OrthoDB55593
GeneTree (enSembl)ENSG00000068308
Phylogenetic Trees/Animal Genes : TreeFamOTUD5
HOVERGENQ96G74
HOGENOMQ96G74
Homologs : HomoloGeneOTUD5
Homology/Alignments : Family Browser (UCSC)OTUD5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOTUD5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OTUD5
dbVarOTUD5
ClinVarOTUD5
1000_GenomesOTUD5 
Exome Variant ServerOTUD5
ExAC (Exome Aggregation Consortium)OTUD5 (select the gene name)
Genetic variants : HAPMAP55593
Genomic Variants (DGV)OTUD5 [DGVbeta]
DECIPHER (Syndromes)X:48779303-48814893  ENSG00000068308
CONAN: Copy Number AnalysisOTUD5 
Mutations
ICGC Data PortalOTUD5 
TCGA Data PortalOTUD5 
Broad Tumor PortalOTUD5
OASIS PortalOTUD5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOTUD5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOTUD5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OTUD5
DgiDB (Drug Gene Interaction Database)OTUD5
DoCM (Curated mutations)OTUD5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OTUD5 (select a term)
intoGenOTUD5
Cancer3DOTUD5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300713   
Orphanet
MedgenOTUD5
Genetic Testing Registry OTUD5
NextProtQ96G74 [Medical]
TSGene55593
GENETestsOTUD5
Huge Navigator OTUD5 [HugePedia]
snp3D : Map Gene to Disease55593
BioCentury BCIQOTUD5
ClinGenOTUD5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55593
Chemical/Pharm GKB GenePA142671217
Clinical trialOTUD5
Miscellaneous
canSAR (ICR)OTUD5 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOTUD5
EVEXOTUD5
GoPubMedOTUD5
iHOPOTUD5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:37:31 CET 2017

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