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OTULIN (OTU deubiquitinase with linear linkage specificity)

Identity

Alias (NCBI)AIPDS
FAM105B
GUM
HGNC (Hugo) OTULIN
HGNC Alias symbFLJ34884
HGNC Alias namegumby
 ubiquitin thioesterase otulin
HGNC Previous nameFAM105B
HGNC Previous namefamily with sequence similarity 105, member B
LocusID (NCBI) 90268
Atlas_Id 55461
Location 5p15.2  [Link to chromosome band 5p15]
Location_base_pair Starts at 14664718 and ends at 14699850 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RABEP1 (17p13.2) / OTULIN (5p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)OTULIN   25118
Cards
Entrez_Gene (NCBI)OTULIN  90268  OTU deubiquitinase with linear linkage specificity
AliasesAIPDS; FAM105B; GUM
GeneCards (Weizmann)OTULIN
Ensembl hg19 (Hinxton)ENSG00000154124 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154124 [Gene_View]  ENSG00000154124 [Sequence]  chr5:14664718-14699850 [Contig_View]  OTULIN [Vega]
ICGC DataPortalENSG00000154124
TCGA cBioPortalOTULIN
AceView (NCBI)OTULIN
Genatlas (Paris)OTULIN
WikiGenes90268
SOURCE (Princeton)OTULIN
Genetics Home Reference (NIH)OTULIN
Genomic and cartography
GoldenPath hg38 (UCSC)OTULIN  -     chr5:14664718-14699850 +  5p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OTULIN  -     5p15.2   [Description]    (hg19-Feb_2009)
GoldenPathOTULIN - 5p15.2 [CytoView hg19]  OTULIN - 5p15.2 [CytoView hg38]
ImmunoBaseENSG00000154124
genome Data Viewer NCBIOTULIN [Mapview hg19]  
OMIM615712   617099   
Gene and transcription
Genbank (Entrez)AK092203 AK095615 AK123480 BC007706 BC015392
RefSeq transcript (Entrez)NM_138348
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OTULIN
Alternative Splicing GalleryENSG00000154124
Gene ExpressionOTULIN [ NCBI-GEO ]   OTULIN [ EBI - ARRAY_EXPRESS ]   OTULIN [ SEEK ]   OTULIN [ MEM ]
Gene Expression Viewer (FireBrowse)OTULIN [ Firebrowse - Broad ]
GenevisibleExpression of OTULIN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90268
GTEX Portal (Tissue expression)OTULIN
Human Protein AtlasENSG00000154124-OTULIN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96BN8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96BN8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96BN8
Splice isoforms : SwissVarQ96BN8
PhosPhoSitePlusQ96BN8
Domains : Interpro (EBI)FAM105    Otulin   
Domain families : Pfam (Sanger)Peptidase_C101 (PF16218)   
Domain families : Pfam (NCBI)pfam16218   
Conserved Domain (NCBI)OTULIN
DMDM Disease mutations90268
Blocks (Seattle)OTULIN
PDB (RSDB)3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B    5OE7    6I9C    6SAK   
PDB Europe3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B    5OE7    6I9C    6SAK   
PDB (PDBSum)3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B    5OE7    6I9C    6SAK   
PDB (IMB)3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B    5OE7    6I9C    6SAK   
Structural Biology KnowledgeBase3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B    5OE7    6I9C    6SAK   
SCOP (Structural Classification of Proteins)3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B    5OE7    6I9C    6SAK   
CATH (Classification of proteins structures)3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B    5OE7    6I9C    6SAK   
SuperfamilyQ96BN8
Human Protein Atlas [tissue]ENSG00000154124-OTULIN [tissue]
Peptide AtlasQ96BN8
HPRD14266
IPIIPI00101734   IPI00964422   IPI00967350   IPI00967622   
Protein Interaction databases
DIP (DOE-UCLA)Q96BN8
IntAct (EBI)Q96BN8
FunCoupENSG00000154124
BioGRIDOTULIN
STRING (EMBL)OTULIN
ZODIACOTULIN
Ontologies - Pathways
QuickGOQ96BN8
Ontology : AmiGOsprouting angiogenesis  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  cytoplasm  cytoplasm  cytosol  cysteine-type peptidase activity  regulation of tumor necrosis factor-mediated signaling pathway  regulation of tumor necrosis factor-mediated signaling pathway  regulation of tumor necrosis factor-mediated signaling pathway  Wnt signaling pathway  protein ubiquitination  negative regulation of NF-kappaB transcription factor activity  negative regulation of NF-kappaB transcription factor activity  negative regulation of NF-kappaB transcription factor activity  innate immune response  innate immune response  innate immune response  negative regulation of inflammatory response  negative regulation of inflammatory response  negative regulation of inflammatory response  regulation of canonical Wnt signaling pathway  nucleotide-binding oligomerization domain containing 2 signaling pathway  LUBAC complex  protein linear deubiquitination  protein linear deubiquitination  
Ontology : EGO-EBIsprouting angiogenesis  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  cytoplasm  cytoplasm  cytosol  cysteine-type peptidase activity  regulation of tumor necrosis factor-mediated signaling pathway  regulation of tumor necrosis factor-mediated signaling pathway  regulation of tumor necrosis factor-mediated signaling pathway  Wnt signaling pathway  protein ubiquitination  negative regulation of NF-kappaB transcription factor activity  negative regulation of NF-kappaB transcription factor activity  negative regulation of NF-kappaB transcription factor activity  innate immune response  innate immune response  innate immune response  negative regulation of inflammatory response  negative regulation of inflammatory response  negative regulation of inflammatory response  regulation of canonical Wnt signaling pathway  nucleotide-binding oligomerization domain containing 2 signaling pathway  LUBAC complex  protein linear deubiquitination  protein linear deubiquitination  
NDEx NetworkOTULIN
Atlas of Cancer Signalling NetworkOTULIN
Wikipedia pathwaysOTULIN
Orthology - Evolution
OrthoDB90268
GeneTree (enSembl)ENSG00000154124
Phylogenetic Trees/Animal Genes : TreeFamOTULIN
HOGENOMQ96BN8
Homologs : HomoloGeneOTULIN
Homology/Alignments : Family Browser (UCSC)OTULIN
Gene fusions - Rearrangements
Fusion : QuiverOTULIN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOTULIN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OTULIN
dbVarOTULIN
ClinVarOTULIN
MonarchOTULIN
1000_GenomesOTULIN 
Exome Variant ServerOTULIN
GNOMAD BrowserENSG00000154124
Varsome BrowserOTULIN
Genetic variants : HAPMAP90268
Genomic Variants (DGV)OTULIN [DGVbeta]
DECIPHEROTULIN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOTULIN 
Mutations
ICGC Data PortalOTULIN 
TCGA Data PortalOTULIN 
Broad Tumor PortalOTULIN
OASIS PortalOTULIN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOTULIN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DOTULIN
Mutations and Diseases : HGMDOTULIN
BioMutasearch OTULIN
DgiDB (Drug Gene Interaction Database)OTULIN
DoCM (Curated mutations)OTULIN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OTULIN (select a term)
intoGenOTULIN
Cancer3DOTULIN(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615712    617099   
Orphanet
DisGeNETOTULIN
MedgenOTULIN
Genetic Testing Registry OTULIN
NextProtQ96BN8 [Medical]
TSGene90268
GENETestsOTULIN
Target ValidationOTULIN
Huge Navigator OTULIN [HugePedia]
snp3D : Map Gene to Disease90268
BioCentury BCIQOTULIN
ClinGenOTULIN
Clinical trials, drugs, therapy
Protein Interactions : CTD90268
Pharm GKB GenePA142671789
Clinical trialOTULIN
Miscellaneous
canSAR (ICR)OTULIN (select the gene name)
HarmonizomeOTULIN
DataMed IndexOTULIN
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOTULIN
EVEXOTULIN
GoPubMedOTULIN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 14 14:25:28 CEST 2020

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