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OTULIN (OTU deubiquitinase with linear linkage specificity)

Identity

Alias_namesFAM105B
family with sequence similarity 105
Alias_symbol (synonym)FLJ34884
Other aliasGUM
HGNC (Hugo) OTULIN
LocusID (NCBI) 90268
Atlas_Id 55461
Location 5p15.2  [Link to chromosome band 5p15]
Location_base_pair Starts at 14664783 and ends at 14699842 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RABEP1 (17p13.2) / OTULIN (5p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OTULIN   25118
Cards
Entrez_Gene (NCBI)OTULIN  90268  OTU deubiquitinase with linear linkage specificity
AliasesFAM105B; GUM
GeneCards (Weizmann)OTULIN
Ensembl hg19 (Hinxton)ENSG00000154124 [Gene_View]  chr5:14664783-14699842 [Contig_View]  OTULIN [Vega]
Ensembl hg38 (Hinxton)ENSG00000154124 [Gene_View]  chr5:14664783-14699842 [Contig_View]  OTULIN [Vega]
ICGC DataPortalENSG00000154124
TCGA cBioPortalOTULIN
AceView (NCBI)OTULIN
Genatlas (Paris)OTULIN
WikiGenes90268
SOURCE (Princeton)OTULIN
Genetics Home Reference (NIH)OTULIN
Genomic and cartography
GoldenPath hg19 (UCSC)OTULIN  -     chr5:14664783-14699842 +  5p15.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)OTULIN  -     5p15.2   [Description]    (hg38-Dec_2013)
EnsemblOTULIN - 5p15.2 [CytoView hg19]  OTULIN - 5p15.2 [CytoView hg38]
Mapping of homologs : NCBIOTULIN [Mapview hg19]  OTULIN [Mapview hg38]
OMIM615712   
Gene and transcription
Genbank (Entrez)AK092203 AK095615 AK123480 BC007706 BC015392
RefSeq transcript (Entrez)NM_138348
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_006576 NW_004929321
Consensus coding sequences : CCDS (NCBI)OTULIN
Cluster EST : UnigeneHs.406335 [ NCBI ]
CGAP (NCI)Hs.406335
Alternative Splicing GalleryENSG00000154124
Gene ExpressionOTULIN [ NCBI-GEO ]   OTULIN [ EBI - ARRAY_EXPRESS ]   OTULIN [ SEEK ]   OTULIN [ MEM ]
Gene Expression Viewer (FireBrowse)OTULIN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90268
GTEX Portal (Tissue expression)OTULIN
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96BN8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96BN8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96BN8
Splice isoforms : SwissVarQ96BN8
PhosPhoSitePlusQ96BN8
Domains : Interpro (EBI)FAM105    Otulin   
Domain families : Pfam (Sanger)Peptidase_C101 (PF16218)   
Domain families : Pfam (NCBI)pfam16218   
Conserved Domain (NCBI)OTULIN
DMDM Disease mutations90268
Blocks (Seattle)OTULIN
PDB (SRS)3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B   
PDB (PDBSum)3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B   
PDB (IMB)3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B   
PDB (RSDB)3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B   
Structural Biology KnowledgeBase3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B   
SCOP (Structural Classification of Proteins)3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B   
CATH (Classification of proteins structures)3ZNV    3ZNX    3ZNZ    4KSJ    4KSK    4KSL    4OYK    4P0B   
SuperfamilyQ96BN8
Human Protein AtlasENSG00000154124
Peptide AtlasQ96BN8
HPRD14266
IPIIPI00101734   IPI00964422   IPI00967350   IPI00967622   
Protein Interaction databases
DIP (DOE-UCLA)Q96BN8
IntAct (EBI)Q96BN8
FunCoupENSG00000154124
BioGRIDOTULIN
STRING (EMBL)OTULIN
ZODIACOTULIN
Ontologies - Pathways
QuickGOQ96BN8
Ontology : AmiGOsprouting angiogenesis  thiol-dependent ubiquitin-specific protease activity  protein binding  cytoplasm  cytosol  cysteine-type peptidase activity  regulation of tumor necrosis factor-mediated signaling pathway  negative regulation of NF-kappaB transcription factor activity  negative regulation of NF-kappaB transcription factor activity  innate immune response  negative regulation of inflammatory response  canonical Wnt signaling pathway  nucleotide-binding oligomerization domain containing 2 signaling pathway  LUBAC complex  protein linear deubiquitination  
Ontology : EGO-EBIsprouting angiogenesis  thiol-dependent ubiquitin-specific protease activity  protein binding  cytoplasm  cytosol  cysteine-type peptidase activity  regulation of tumor necrosis factor-mediated signaling pathway  negative regulation of NF-kappaB transcription factor activity  negative regulation of NF-kappaB transcription factor activity  innate immune response  negative regulation of inflammatory response  canonical Wnt signaling pathway  nucleotide-binding oligomerization domain containing 2 signaling pathway  LUBAC complex  protein linear deubiquitination  
NDEx NetworkOTULIN
Atlas of Cancer Signalling NetworkOTULIN
Wikipedia pathwaysOTULIN
Orthology - Evolution
OrthoDB90268
GeneTree (enSembl)ENSG00000154124
Phylogenetic Trees/Animal Genes : TreeFamOTULIN
HOVERGENQ96BN8
HOGENOMQ96BN8
Homologs : HomoloGeneOTULIN
Homology/Alignments : Family Browser (UCSC)OTULIN
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOTULIN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OTULIN
dbVarOTULIN
ClinVarOTULIN
1000_GenomesOTULIN 
Exome Variant ServerOTULIN
ExAC (Exome Aggregation Consortium)OTULIN (select the gene name)
Genetic variants : HAPMAP90268
Genomic Variants (DGV)OTULIN [DGVbeta]
DECIPHER (Syndromes)5:14664783-14699842  ENSG00000154124
CONAN: Copy Number AnalysisOTULIN 
Mutations
ICGC Data PortalOTULIN 
TCGA Data PortalOTULIN 
Broad Tumor PortalOTULIN
OASIS PortalOTULIN [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDOTULIN
BioMutasearch OTULIN
DgiDB (Drug Gene Interaction Database)OTULIN
DoCM (Curated mutations)OTULIN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OTULIN (select a term)
intoGenOTULIN
Cancer3DOTULIN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615712   
Orphanet
MedgenOTULIN
Genetic Testing Registry OTULIN
NextProtQ96BN8 [Medical]
TSGene90268
GENETestsOTULIN
Huge Navigator OTULIN [HugePedia]
snp3D : Map Gene to Disease90268
BioCentury BCIQOTULIN
ClinGenOTULIN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD90268
Chemical/Pharm GKB GenePA142671789
Clinical trialOTULIN
Miscellaneous
canSAR (ICR)OTULIN (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOTULIN
EVEXOTULIN
GoPubMedOTULIN
iHOPOTULIN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:20:02 CET 2017

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