OVOL2 (ovo like zinc finger 2)

2016-08-01  

Identity

HGNC
LOCATION
20p11.23
LOCUSID
ALIAS
CHED,CHED1,CHED2,EUROIMAGE566589,PPCD1,ZNF339
FUSION GENES

Other Information

Locus ID:

NCBI: 58495
MIM: 616441
HGNC: 15804
Ensembl: ENSG00000125850

Variants:

dbSNP: 58495
ClinVar: 58495
TCGA: ENSG00000125850
COSMIC: OVOL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125850ENST00000278780Q9BRP0

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197004102009Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1.21
271341772016OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition.19
297210732018OVOL2 links stemness and metastasis via fine-tuning epithelial-mesenchymal transition in nasopharyngeal carcinoma.18
267493092016Autosomal-Dominant Corneal Endothelial Dystrophies CHED1 and PPCD1 Are Allelic Disorders Caused by Non-coding Mutations in the Promoter of OVOL2.15
126543612003Clinicopathologic correlation and genetic analysis in a case of posterior polymorphous corneal dystrophy.13
195749042009Exclusion of positional candidate gene coding region mutations in the common posterior polymorphous corneal dystrophy 1 candidate gene interval.9
278847722017Ovol2 gene inhibits the Epithelial-to-Mesenchymal Transition in lung adenocarcinoma by transcriptionally repressing Twist1.9
283394252017Potential role of the OVOL1-OVOL2 axis and c-Myc in the progression of cutaneous squamous cell carcinoma.9
266199632016OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors.8
268734472016Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma.8

Citation

Dessen P

OVOL2 (ovo like zinc finger 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55831/ovol2