Atlas of Genetics and Cytogenetics in Oncology and Haematology


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OVOL2 (ovo like zinc finger 2)

Identity

Alias_namesZNF339
zinc finger protein 339
ovo-like 2 (Drosophila)
Alias_symbol (synonym)bA504H3.3
HOVO2
Other aliasCHED
CHED1
CHED2
EUROIMAGE566589
PPCD1
HGNC (Hugo) OVOL2
LocusID (NCBI) 58495
Atlas_Id 55831
Location 20p11.23  [Link to chromosome band 20p11]
Location_base_pair Starts at 18024152 and ends at 18057882 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
OVOL2 (20p11.23) / KIAA0922 (4q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OVOL2   15804
Cards
Entrez_Gene (NCBI)OVOL2  58495  ovo like zinc finger 2
AliasesCHED; CHED1; CHED2; EUROIMAGE566589; 
PPCD1; ZNF339
GeneCards (Weizmann)OVOL2
Ensembl hg19 (Hinxton)ENSG00000125850 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125850 [Gene_View]  ENSG00000125850 [Sequence]  chr20:18024152-18057882 [Contig_View]  OVOL2 [Vega]
ICGC DataPortalENSG00000125850
TCGA cBioPortalOVOL2
AceView (NCBI)OVOL2
Genatlas (Paris)OVOL2
WikiGenes58495
SOURCE (Princeton)OVOL2
Genetics Home Reference (NIH)OVOL2
Genomic and cartography
GoldenPath hg38 (UCSC)OVOL2  -     chr20:18024152-18057882 -  20p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)OVOL2  -     20p11.23   [Description]    (hg19-Feb_2009)
EnsemblOVOL2 - 20p11.23 [CytoView hg19]  OVOL2 - 20p11.23 [CytoView hg38]
Mapping of homologs : NCBIOVOL2 [Mapview hg19]  OVOL2 [Mapview hg38]
OMIM122000   616441   
Gene and transcription
Genbank (Entrez)AI811832 AK022284 AL079276 BC006148 BE791524
RefSeq transcript (Entrez)NM_001303461 NM_001303462 NM_021220
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)OVOL2
Cluster EST : UnigeneHs.710157 [ NCBI ]
CGAP (NCI)Hs.710157
Alternative Splicing GalleryENSG00000125850
Gene ExpressionOVOL2 [ NCBI-GEO ]   OVOL2 [ EBI - ARRAY_EXPRESS ]   OVOL2 [ SEEK ]   OVOL2 [ MEM ]
Gene Expression Viewer (FireBrowse)OVOL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)58495
GTEX Portal (Tissue expression)OVOL2
Human Protein AtlasENSG00000125850-OVOL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BRP0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BRP0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BRP0
Splice isoforms : SwissVarQ9BRP0
PhosPhoSitePlusQ9BRP0
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Ovo-like    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)OVOL2
DMDM Disease mutations58495
Blocks (Seattle)OVOL2
SuperfamilyQ9BRP0
Human Protein Atlas [tissue]ENSG00000125850-OVOL2 [tissue]
Peptide AtlasQ9BRP0
HPRD15780
IPIIPI00305086   IPI00944940   
Protein Interaction databases
DIP (DOE-UCLA)Q9BRP0
IntAct (EBI)Q9BRP0
FunCoupENSG00000125850
BioGRIDOVOL2
STRING (EMBL)OVOL2
ZODIACOVOL2
Ontologies - Pathways
QuickGOQ9BRP0
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  DNA-binding transcription factor activity, RNA polymerase II-specific  proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  angiogenesis  neural crest cell migration  neural fold formation  heart looping  chromatin binding  nucleus  nucleus  epidermal cell differentiation  dorsal/ventral pattern formation  positive regulation of gene expression  negative regulation of gene expression  negative regulation of epithelial to mesenchymal transition  negative regulation of epithelial to mesenchymal transition  regulation of keratinocyte proliferation  sequence-specific DNA binding  positive regulation of keratinocyte differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  metal ion binding  embryonic digestive tract morphogenesis  endocardium formation  heart trabecula formation  regulation of SMAD protein signal transduction  labyrinthine layer blood vessel development  cellular response to transforming growth factor beta stimulus  negative regulation of stem cell proliferation  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  DNA-binding transcription factor activity, RNA polymerase II-specific  proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  angiogenesis  neural crest cell migration  neural fold formation  heart looping  chromatin binding  nucleus  nucleus  epidermal cell differentiation  dorsal/ventral pattern formation  positive regulation of gene expression  negative regulation of gene expression  negative regulation of epithelial to mesenchymal transition  negative regulation of epithelial to mesenchymal transition  regulation of keratinocyte proliferation  sequence-specific DNA binding  positive regulation of keratinocyte differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  metal ion binding  embryonic digestive tract morphogenesis  endocardium formation  heart trabecula formation  regulation of SMAD protein signal transduction  labyrinthine layer blood vessel development  cellular response to transforming growth factor beta stimulus  negative regulation of stem cell proliferation  
NDEx NetworkOVOL2
Atlas of Cancer Signalling NetworkOVOL2
Wikipedia pathwaysOVOL2
Orthology - Evolution
OrthoDB58495
GeneTree (enSembl)ENSG00000125850
Phylogenetic Trees/Animal Genes : TreeFamOVOL2
HOVERGENQ9BRP0
HOGENOMQ9BRP0
Homologs : HomoloGeneOVOL2
Homology/Alignments : Family Browser (UCSC)OVOL2
Gene fusions - Rearrangements
Fusion : QuiverOVOL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOVOL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OVOL2
dbVarOVOL2
ClinVarOVOL2
1000_GenomesOVOL2 
Exome Variant ServerOVOL2
ExAC (Exome Aggregation Consortium)ENSG00000125850
GNOMAD BrowserENSG00000125850
Varsome BrowserOVOL2
Genetic variants : HAPMAP58495
Genomic Variants (DGV)OVOL2 [DGVbeta]
DECIPHEROVOL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisOVOL2 
Mutations
ICGC Data PortalOVOL2 
TCGA Data PortalOVOL2 
Broad Tumor PortalOVOL2
OASIS PortalOVOL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOVOL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOVOL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch OVOL2
DgiDB (Drug Gene Interaction Database)OVOL2
DoCM (Curated mutations)OVOL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OVOL2 (select a term)
intoGenOVOL2
Cancer3DOVOL2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM122000    616441   
Orphanet13990    13992   
DisGeNETOVOL2
MedgenOVOL2
Genetic Testing Registry OVOL2
NextProtQ9BRP0 [Medical]
TSGene58495
GENETestsOVOL2
Target ValidationOVOL2
Huge Navigator OVOL2 [HugePedia]
snp3D : Map Gene to Disease58495
BioCentury BCIQOVOL2
ClinGenOVOL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD58495
Chemical/Pharm GKB GenePA38039
Clinical trialOVOL2
Miscellaneous
canSAR (ICR)OVOL2 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOVOL2
EVEXOVOL2
GoPubMedOVOL2
iHOPOVOL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:28:06 CET 2018

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