Atlas of Genetics and Cytogenetics in Oncology and Haematology


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OXCT1 (3-oxoacid CoA-transferase 1)

Identity

Alias_namesOXCT
3-oxoacid CoA transferase
3-oxoacid CoA transferase 1
Alias_symbol (synonym)SCOT
Other alias
HGNC (Hugo) OXCT1
LocusID (NCBI) 5019
Atlas_Id 53959
Location 5p13.1  [Link to chromosome band 5p13]
Location_base_pair Starts at 41730167 and ends at 41870791 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HMGCS1 (5p12) / OXCT1 (5p13.1)OXCT1 (5p13.1) / TMEM17 (2p15)HMGCS1 5p12 / OXCT1 5p13.1
OXCT1 5p13.1 / TMEM17 2p15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)OXCT1   8527
Cards
Entrez_Gene (NCBI)OXCT1  5019  3-oxoacid CoA-transferase 1
AliasesOXCT; SCOT
GeneCards (Weizmann)OXCT1
Ensembl hg19 (Hinxton)ENSG00000083720 [Gene_View]  chr5:41730167-41870791 [Contig_View]  OXCT1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000083720 [Gene_View]  chr5:41730167-41870791 [Contig_View]  OXCT1 [Vega]
ICGC DataPortalENSG00000083720
TCGA cBioPortalOXCT1
AceView (NCBI)OXCT1
Genatlas (Paris)OXCT1
WikiGenes5019
SOURCE (Princeton)OXCT1
Genetics Home Reference (NIH)OXCT1
Genomic and cartography
GoldenPath hg19 (UCSC)OXCT1  -     chr5:41730167-41870791 -  5p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)OXCT1  -     5p13.1   [Description]    (hg38-Dec_2013)
EnsemblOXCT1 - 5p13.1 [CytoView hg19]  OXCT1 - 5p13.1 [CytoView hg38]
Mapping of homologs : NCBIOXCT1 [Mapview hg19]  OXCT1 [Mapview hg38]
OMIM245050   601424   
Gene and transcription
Genbank (Entrez)AK125115 AK298352 AK299668 AK312327 AK315902
RefSeq transcript (Entrez)NM_000436
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_011823 NT_006576 NW_004929321
Consensus coding sequences : CCDS (NCBI)OXCT1
Cluster EST : UnigeneHs.278277 [ NCBI ]
CGAP (NCI)Hs.278277
Alternative Splicing GalleryENSG00000083720
Gene ExpressionOXCT1 [ NCBI-GEO ]   OXCT1 [ EBI - ARRAY_EXPRESS ]   OXCT1 [ SEEK ]   OXCT1 [ MEM ]
Gene Expression Viewer (FireBrowse)OXCT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5019
GTEX Portal (Tissue expression)OXCT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55809   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55809  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55809
Splice isoforms : SwissVarP55809
Catalytic activity : Enzyme2.8.3.5 [ Enzyme-Expasy ]   2.8.3.52.8.3.5 [ IntEnz-EBI ]   2.8.3.5 [ BRENDA ]   2.8.3.5 [ KEGG ]   
PhosPhoSitePlusP55809
Domaine pattern : Prosite (Expaxy)COA_TRANSF_1 (PS01273)    COA_TRANSF_2 (PS01274)   
Domains : Interpro (EBI)3-oxoacid_CoA-transf_A    3-oxoacid_CoA-transf_B    3-oxoacid_CoA-transferase    CoA_trans_fam_I    CoA_transf_AS    CoA_transf_BS   
Domain families : Pfam (Sanger)CoA_trans (PF01144)   
Domain families : Pfam (NCBI)pfam01144   
Domain families : Smart (EMBL)CoA_trans (SM00882)  
Conserved Domain (NCBI)OXCT1
DMDM Disease mutations5019
Blocks (Seattle)OXCT1
PDB (SRS)3DLX   
PDB (PDBSum)3DLX   
PDB (IMB)3DLX   
PDB (RSDB)3DLX   
Structural Biology KnowledgeBase3DLX   
SCOP (Structural Classification of Proteins)3DLX   
CATH (Classification of proteins structures)3DLX   
SuperfamilyP55809
Human Protein AtlasENSG00000083720
Peptide AtlasP55809
HPRD02001
IPIIPI00026516   IPI01012468   IPI00980996   IPI00964493   IPI00967390   
Protein Interaction databases
DIP (DOE-UCLA)P55809
IntAct (EBI)P55809
FunCoupENSG00000083720
BioGRIDOXCT1
STRING (EMBL)OXCT1
ZODIACOXCT1
Ontologies - Pathways
QuickGOP55809
Ontology : AmiGOmitochondrion  mitochondrion  mitochondrial matrix  brain development  heart development  response to nutrient  3-oxoacid CoA-transferase activity  3-oxoacid CoA-transferase activity  response to hormone  response to activity  positive regulation of insulin secretion involved in cellular response to glucose stimulus  ketone catabolic process  response to drug  response to starvation  protein homodimerization activity  response to ethanol  cellular ketone body metabolic process  ketone body catabolic process  adipose tissue development  
Ontology : EGO-EBImitochondrion  mitochondrion  mitochondrial matrix  brain development  heart development  response to nutrient  3-oxoacid CoA-transferase activity  3-oxoacid CoA-transferase activity  response to hormone  response to activity  positive regulation of insulin secretion involved in cellular response to glucose stimulus  ketone catabolic process  response to drug  response to starvation  protein homodimerization activity  response to ethanol  cellular ketone body metabolic process  ketone body catabolic process  adipose tissue development  
Pathways : KEGGSynthesis and degradation of ketone bodies    Valine, leucine and isoleucine degradation    Butanoate metabolism   
NDEx NetworkOXCT1
Atlas of Cancer Signalling NetworkOXCT1
Wikipedia pathwaysOXCT1
Orthology - Evolution
OrthoDB5019
GeneTree (enSembl)ENSG00000083720
Phylogenetic Trees/Animal Genes : TreeFamOXCT1
HOVERGENP55809
HOGENOMP55809
Homologs : HomoloGeneOXCT1
Homology/Alignments : Family Browser (UCSC)OXCT1
Gene fusions - Rearrangements
Fusion : MitelmanHMGCS1/OXCT1 [5p12/5p13.1]  [t(5;5)(p12;p13)]  
Fusion : MitelmanOXCT1/TMEM17 [5p13.1/2p15]  [t(2;5)(p15;p13)]  
Fusion: TCGAHMGCS1 5p12 OXCT1 5p13.1 LGG
Fusion: TCGAOXCT1 5p13.1 TMEM17 2p15 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerOXCT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)OXCT1
dbVarOXCT1
ClinVarOXCT1
1000_GenomesOXCT1 
Exome Variant ServerOXCT1
ExAC (Exome Aggregation Consortium)OXCT1 (select the gene name)
Genetic variants : HAPMAP5019
Genomic Variants (DGV)OXCT1 [DGVbeta]
DECIPHER (Syndromes)5:41730167-41870791  ENSG00000083720
CONAN: Copy Number AnalysisOXCT1 
Mutations
ICGC Data PortalOXCT1 
TCGA Data PortalOXCT1 
Broad Tumor PortalOXCT1
OASIS PortalOXCT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICOXCT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDOXCT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch OXCT1
DgiDB (Drug Gene Interaction Database)OXCT1
DoCM (Curated mutations)OXCT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)OXCT1 (select a term)
intoGenOXCT1
Cancer3DOXCT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM245050    601424   
Orphanet3298   
MedgenOXCT1
Genetic Testing Registry OXCT1
NextProtP55809 [Medical]
TSGene5019
GENETestsOXCT1
Huge Navigator OXCT1 [HugePedia]
snp3D : Map Gene to Disease5019
BioCentury BCIQOXCT1
ClinGenOXCT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5019
Chemical/Pharm GKB GenePA32855
Clinical trialOXCT1
Miscellaneous
canSAR (ICR)OXCT1 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineOXCT1
EVEXOXCT1
GoPubMedOXCT1
iHOPOXCT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:20:05 CET 2017

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