OXR1 (oxidation resistance 1)

2014-08-01  

Identity

HGNC
OXR1
LOCATION
8q23.1
LOCUSID
55074
ALIAS
CHEGDD,Nbla00307,TLDC3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55074
MIM: 605609
HGNC: 15822
Ensembl: ENSG00000164830

Variants:

dbSNP: 55074
ClinVar: 55074
TCGA: ENSG00000164830
COSMIC: OXR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164830ENST00000297447Q8N573
ENSG00000164830ENST00000312046Q8N573
ENSG00000164830ENST00000435082C9JY63
ENSG00000164830ENST00000438229E5RFD1
ENSG00000164830ENST00000442977Q8N573
ENSG00000164830ENST00000449762Q8N573
ENSG00000164830ENST00000497705Q8N573
ENSG00000164830ENST00000517566Q8N573
ENSG00000164830ENST00000517686E5RII8
ENSG00000164830ENST00000519415H0YC07
ENSG00000164830ENST00000521592E9PLW2
ENSG00000164830ENST00000531443Q8N573

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
150601422004Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans.36
173915162007The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins.28
257927262015Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations.18
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
252367442014Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21.16
266165342015Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway.13
297666392018Oxidation resistance 1 is a novel senolytic target.10
228734012012Structural/functional analysis of the human OXR1 protein: identification of exon 8 as the anti-oxidant encoding function.9
308529772019MicroRNA-373 promotes the development of esophageal squamous cell carcinoma by targeting LATS2 and OXR1.1
316424822019Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo.1

Citation

Dessen P

OXR1 (oxidation resistance 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54522/oxr1