OXSR1 (oxidative stress responsive kinase 1)

2003-06-01  

Identity

HGNC
LOCATION
3p22.2
LOCUSID
ALIAS
OSR1
FUSION GENES

Other Information

Locus ID:

NCBI: 9943
MIM: 604046
HGNC: 8508
Ensembl: ENSG00000172939

Variants:

dbSNP: 9943
ClinVar: 9943
TCGA: ENSG00000172939
COSMIC: OXSR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172939ENST00000311806O95747
ENSG00000172939ENST00000311806A0A024R2M7
ENSG00000172939ENST00000426620F8WBK9
ENSG00000172939ENST00000446845C9JIG9

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA320SLC12A1GenePathwayassociated23788015
PA38243STK39GenePathwayassociated23788015

References

Pubmed IDYearTitleCitations
162637222005WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.168
182702622008Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.148
123861652002Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).140
166697872006Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.96
168320452006WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.71
213213282011Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.61
243930352014The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.58
208199792011Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia.37
147071322004Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.34
177214392007Structural insights into the recognition of substrates and activators by the OSR1 kinase.30

Citation

Dessen P

OXSR1 (oxidative stress responsive kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41617/oxsr1