OXT (oxytocin/neurophysin I prepropeptide)

2007-02-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
OT,OT-NPI,OXT-NPI

Other Information

Locus ID:

NCBI: 5020
MIM: 167050
HGNC: 8528
Ensembl: ENSG00000101405

Variants:

dbSNP: 5020
ClinVar: 5020
TCGA: ENSG00000101405
COSMIC: OXT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101405ENST00000217386P01178
ENSG00000101405ENST00000217386X5D7M6

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Vasopressin-like receptorsREACTOMER-HSA-388479
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171375612007Oxytocin improves "mind-reading" in humans.292
203718202010Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans.186
222859342012Oxytocin and social affiliation in humans.120
238561872013The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences.116
223365632012Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes.108
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
222453142012The contributions of oxytocin and vasopressin pathway genes to human behavior.83
215624822011Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression.77
222272782012Oxytocin modulates cooperation within and competition between groups: an integrative review and research agenda.72

Citation

Dessen P

OXT (oxytocin/neurophysin I prepropeptide)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45947/oxt