OXTR (oxytocin receptor)

2007-12-01  

Identity

HGNC
OXTR
LOCATION
3p25.3
LOCUSID
5021
ALIAS
OT-R,OTR

Other Information

Locus ID:

NCBI: 5021
MIM: 167055
HGNC: 8529
Ensembl: ENSG00000180914

Variants:

dbSNP: 5021
ClinVar: 5021
TCGA: ENSG00000180914
COSMIC: OXTR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180914ENST00000316793P30559
ENSG00000180914ENST00000316793B2R9L7
ENSG00000180914ENST00000431493C9JQC4
ENSG00000180914ENST00000449615C9JN09

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Vasopressin-like receptorsREACTOMER-HSA-388479
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
199340462009Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans.199
199340462009Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans.199
198459722009Genomic and epigenetic evidence for oxytocin receptor deficiency in autism.177
159925262005Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population.162
190151032008Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting.152
190151032008Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting.152
206473842010A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function.152
173838192007Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism.136
173838192007Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism.136
178937052008Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition.118

Citation

Dessen P

OXTR (oxytocin receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49935/oxtr