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P2RX1 (purinergic receptor P2X 1)

Identity

Alias_namespurinergic receptor P2X
Alias_symbol (synonym)P2X1
Other alias
HGNC (Hugo) P2RX1
LocusID (NCBI) 5023
Atlas_Id 52052
Location 17p13.2  [Link to chromosome band 17p13]
Location_base_pair Starts at 3896591 and ends at 3916666 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MEF2D (1q22) / P2RX1 (17p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)P2RX1   8533
Cards
Entrez_Gene (NCBI)P2RX1  5023  purinergic receptor P2X 1
AliasesP2X1
GeneCards (Weizmann)P2RX1
Ensembl hg19 (Hinxton)ENSG00000108405 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108405 [Gene_View]  chr17:3896591-3916666 [Contig_View]  P2RX1 [Vega]
ICGC DataPortalENSG00000108405
TCGA cBioPortalP2RX1
AceView (NCBI)P2RX1
Genatlas (Paris)P2RX1
WikiGenes5023
SOURCE (Princeton)P2RX1
Genetics Home Reference (NIH)P2RX1
Genomic and cartography
GoldenPath hg38 (UCSC)P2RX1  -     chr17:3896591-3916666 -  17p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)P2RX1  -     17p13.2   [Description]    (hg19-Feb_2009)
EnsemblP2RX1 - 17p13.2 [CytoView hg19]  P2RX1 - 17p13.2 [CytoView hg38]
Mapping of homologs : NCBIP2RX1 [Mapview hg19]  P2RX1 [Mapview hg38]
OMIM600845   609821   
Gene and transcription
Genbank (Entrez)AF020498 AK310981 AK313264 BC027949 BC044657
RefSeq transcript (Entrez)NM_002558
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)P2RX1
Cluster EST : UnigeneHs.41735 [ NCBI ]
CGAP (NCI)Hs.41735
Alternative Splicing GalleryENSG00000108405
Gene ExpressionP2RX1 [ NCBI-GEO ]   P2RX1 [ EBI - ARRAY_EXPRESS ]   P2RX1 [ SEEK ]   P2RX1 [ MEM ]
Gene Expression Viewer (FireBrowse)P2RX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5023
GTEX Portal (Tissue expression)P2RX1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51575   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51575  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51575
Splice isoforms : SwissVarP51575
PhosPhoSitePlusP51575
Domaine pattern : Prosite (Expaxy)P2X_RECEPTOR (PS01212)   
Domains : Interpro (EBI)P2X1_purnocptor    P2X_extracellular_dom    P2X_purnocptor   
Domain families : Pfam (Sanger)P2X_receptor (PF00864)   
Domain families : Pfam (NCBI)pfam00864   
Conserved Domain (NCBI)P2RX1
DMDM Disease mutations5023
Blocks (Seattle)P2RX1
SuperfamilyP51575
Human Protein AtlasENSG00000108405
Peptide AtlasP51575
HPRD07526
IPIIPI00019391   
Protein Interaction databases
DIP (DOE-UCLA)P51575
IntAct (EBI)P51575
FunCoupENSG00000108405
BioGRIDP2RX1
STRING (EMBL)P2RX1
ZODIACP2RX1
Ontologies - Pathways
QuickGOP51575
Ontology : AmiGOpurinergic nucleotide receptor activity  serotonin secretion by platelet  regulation of vascular smooth muscle contraction  extracellular ATP-gated cation channel activity  cation channel activity  ATP binding  integral component of nuclear inner membrane  plasma membrane  integral component of plasma membrane  transport  ion transport  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  signal transduction  insemination  blood coagulation  drug binding  regulation of blood pressure  zinc ion binding  neuronal action potential  platelet activation  secretory granule membrane  response to ATP  synaptic transmission, glutamatergic  specific granule membrane  purinergic nucleotide receptor signaling pathway  vasoconstriction  neuron projection  protein complex  positive regulation of ion transport  neutrophil degranulation  membrane raft  postsynaptic membrane  ceramide biosynthetic process  protein homooligomerization  protein heterooligomerization  regulation of calcium ion transport  excitatory postsynaptic potential  cation transmembrane transport  
Ontology : EGO-EBIpurinergic nucleotide receptor activity  serotonin secretion by platelet  regulation of vascular smooth muscle contraction  extracellular ATP-gated cation channel activity  cation channel activity  ATP binding  integral component of nuclear inner membrane  plasma membrane  integral component of plasma membrane  transport  ion transport  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  signal transduction  insemination  blood coagulation  drug binding  regulation of blood pressure  zinc ion binding  neuronal action potential  platelet activation  secretory granule membrane  response to ATP  synaptic transmission, glutamatergic  specific granule membrane  purinergic nucleotide receptor signaling pathway  vasoconstriction  neuron projection  protein complex  positive regulation of ion transport  neutrophil degranulation  membrane raft  postsynaptic membrane  ceramide biosynthetic process  protein homooligomerization  protein heterooligomerization  regulation of calcium ion transport  excitatory postsynaptic potential  cation transmembrane transport  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction   
NDEx NetworkP2RX1
Atlas of Cancer Signalling NetworkP2RX1
Wikipedia pathwaysP2RX1
Orthology - Evolution
OrthoDB5023
GeneTree (enSembl)ENSG00000108405
Phylogenetic Trees/Animal Genes : TreeFamP2RX1
HOVERGENP51575
HOGENOMP51575
Homologs : HomoloGeneP2RX1
Homology/Alignments : Family Browser (UCSC)P2RX1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerP2RX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)P2RX1
dbVarP2RX1
ClinVarP2RX1
1000_GenomesP2RX1 
Exome Variant ServerP2RX1
ExAC (Exome Aggregation Consortium)P2RX1 (select the gene name)
Genetic variants : HAPMAP5023
Genomic Variants (DGV)P2RX1 [DGVbeta]
DECIPHERP2RX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisP2RX1 
Mutations
ICGC Data PortalP2RX1 
TCGA Data PortalP2RX1 
Broad Tumor PortalP2RX1
OASIS PortalP2RX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICP2RX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDP2RX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch P2RX1
DgiDB (Drug Gene Interaction Database)P2RX1
DoCM (Curated mutations)P2RX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)P2RX1 (select a term)
intoGenP2RX1
Cancer3DP2RX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600845    609821   
Orphanet
MedgenP2RX1
Genetic Testing Registry P2RX1
NextProtP51575 [Medical]
TSGene5023
GENETestsP2RX1
Huge Navigator P2RX1 [HugePedia]
snp3D : Map Gene to Disease5023
BioCentury BCIQP2RX1
ClinGenP2RX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5023
Chemical/Pharm GKB GenePA32861
Clinical trialP2RX1
Miscellaneous
canSAR (ICR)P2RX1 (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineP2RX1
EVEXP2RX1
GoPubMedP2RX1
iHOPP2RX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri May 19 12:29:57 CEST 2017

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