Atlas of Genetics and Cytogenetics in Oncology and Haematology


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P2RX3 (purinergic receptor P2X 3)

Identity

Alias_namespurinergic receptor P2X
Alias_symbol (synonym)P2X3
Other alias
HGNC (Hugo) P2RX3
LocusID (NCBI) 5024
Atlas_Id 56601
Location 11q12.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 57105841 and ends at 57137549 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PCSK4 (19p13.3) / P2RX3 (11q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)P2RX3   8534
Cards
Entrez_Gene (NCBI)P2RX3  5024  purinergic receptor P2X 3
AliasesP2X3
GeneCards (Weizmann)P2RX3
Ensembl hg19 (Hinxton)ENSG00000109991 [Gene_View]  chr11:57105841-57137549 [Contig_View]  P2RX3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000109991 [Gene_View]  chr11:57105841-57137549 [Contig_View]  P2RX3 [Vega]
ICGC DataPortalENSG00000109991
TCGA cBioPortalP2RX3
AceView (NCBI)P2RX3
Genatlas (Paris)P2RX3
WikiGenes5024
SOURCE (Princeton)P2RX3
Genetics Home Reference (NIH)P2RX3
Genomic and cartography
GoldenPath hg19 (UCSC)P2RX3  -     chr11:57105841-57137549 +  11q12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)P2RX3  -     11q12.1   [Description]    (hg38-Dec_2013)
EnsemblP2RX3 - 11q12.1 [CytoView hg19]  P2RX3 - 11q12.1 [CytoView hg38]
Mapping of homologs : NCBIP2RX3 [Mapview hg19]  P2RX3 [Mapview hg38]
OMIM600843   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_002559
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)P2RX3
Cluster EST : UnigeneHs.146738 [ NCBI ]
CGAP (NCI)Hs.146738
Alternative Splicing GalleryENSG00000109991
Gene ExpressionP2RX3 [ NCBI-GEO ]   P2RX3 [ EBI - ARRAY_EXPRESS ]   P2RX3 [ SEEK ]   P2RX3 [ MEM ]
Gene Expression Viewer (FireBrowse)P2RX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5024
GTEX Portal (Tissue expression)P2RX3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56373   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56373  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56373
Splice isoforms : SwissVarP56373
PhosPhoSitePlusP56373
Domaine pattern : Prosite (Expaxy)P2X_RECEPTOR (PS01212)   
Domains : Interpro (EBI)P2X3_purnocptor    P2X_extracellular_dom    P2X_purnocptor   
Domain families : Pfam (Sanger)P2X_receptor (PF00864)   
Domain families : Pfam (NCBI)pfam00864   
Conserved Domain (NCBI)P2RX3
DMDM Disease mutations5024
Blocks (Seattle)P2RX3
SuperfamilyP56373
Human Protein AtlasENSG00000109991
Peptide AtlasP56373
HPRD09016
IPIIPI00290106   IPI00939723   
Protein Interaction databases
DIP (DOE-UCLA)P56373
IntAct (EBI)P56373
FunCoupENSG00000109991
BioGRIDP2RX3
STRING (EMBL)P2RX3
ZODIACP2RX3
Ontologies - Pathways
QuickGOP56373
Ontology : AmiGOpurinergic nucleotide receptor activity  purinergic nucleotide receptor activity  response to hypoxia  extracellular ATP-gated cation channel activity  ATP binding  integral component of nuclear inner membrane  rough endoplasmic reticulum  Golgi apparatus  plasma membrane  integral component of plasma membrane  transport  signal transduction  neuromuscular synaptic transmission  blood coagulation  response to heat  response to cold  response to mechanical stimulus  response to carbohydrate  positive regulation of calcium ion transport into cytosol  urinary bladder smooth muscle contraction  neuronal action potential  peristalsis  response to ATP  purinergic nucleotide receptor signaling pathway  neuronal cell body  terminal bouton  dendritic spine  receptor complex  membrane raft  regulation of synaptic plasticity  positive regulation of calcium-mediated signaling  sensory perception of taste  protein homooligomerization  behavioral response to formalin induced pain  cation transmembrane transport  positive regulation of sensory perception of pain  
Ontology : EGO-EBIpurinergic nucleotide receptor activity  purinergic nucleotide receptor activity  response to hypoxia  extracellular ATP-gated cation channel activity  ATP binding  integral component of nuclear inner membrane  rough endoplasmic reticulum  Golgi apparatus  plasma membrane  integral component of plasma membrane  transport  signal transduction  neuromuscular synaptic transmission  blood coagulation  response to heat  response to cold  response to mechanical stimulus  response to carbohydrate  positive regulation of calcium ion transport into cytosol  urinary bladder smooth muscle contraction  neuronal action potential  peristalsis  response to ATP  purinergic nucleotide receptor signaling pathway  neuronal cell body  terminal bouton  dendritic spine  receptor complex  membrane raft  regulation of synaptic plasticity  positive regulation of calcium-mediated signaling  sensory perception of taste  protein homooligomerization  behavioral response to formalin induced pain  cation transmembrane transport  positive regulation of sensory perception of pain  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction   
NDEx NetworkP2RX3
Atlas of Cancer Signalling NetworkP2RX3
Wikipedia pathwaysP2RX3
Orthology - Evolution
OrthoDB5024
GeneTree (enSembl)ENSG00000109991
Phylogenetic Trees/Animal Genes : TreeFamP2RX3
HOVERGENP56373
HOGENOMP56373
Homologs : HomoloGeneP2RX3
Homology/Alignments : Family Browser (UCSC)P2RX3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerP2RX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)P2RX3
dbVarP2RX3
ClinVarP2RX3
1000_GenomesP2RX3 
Exome Variant ServerP2RX3
ExAC (Exome Aggregation Consortium)P2RX3 (select the gene name)
Genetic variants : HAPMAP5024
Genomic Variants (DGV)P2RX3 [DGVbeta]
DECIPHER (Syndromes)11:57105841-57137549  ENSG00000109991
CONAN: Copy Number AnalysisP2RX3 
Mutations
ICGC Data PortalP2RX3 
TCGA Data PortalP2RX3 
Broad Tumor PortalP2RX3
OASIS PortalP2RX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICP2RX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDP2RX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch P2RX3
DgiDB (Drug Gene Interaction Database)P2RX3
DoCM (Curated mutations)P2RX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)P2RX3 (select a term)
intoGenP2RX3
Cancer3DP2RX3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600843   
Orphanet
MedgenP2RX3
Genetic Testing Registry P2RX3
NextProtP56373 [Medical]
TSGene5024
GENETestsP2RX3
Huge Navigator P2RX3 [HugePedia]
snp3D : Map Gene to Disease5024
BioCentury BCIQP2RX3
ClinGenP2RX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5024
Chemical/Pharm GKB GenePA32863
Clinical trialP2RX3
Miscellaneous
canSAR (ICR)P2RX3 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineP2RX3
EVEXP2RX3
GoPubMedP2RX3
iHOPP2RX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:13:19 CEST 2017

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