P2RX3 (purinergic receptor P2X 3)

2016-10-01 Affiliation

Identity

HGNC

P2RX3

LOCATION

11q12.1

LOCUSID

5024

ALIAS

P2X3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5024
MIM: 600843
HGNC: 8534
Ensembl: ENSG00000109991

Variants:

dbSNP: 5024
ClinVar: 5024
TCGA: ENSG00000109991
COSMIC: P2RX3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000109991	ENST00000263314	P56373
ENSG00000109991	ENST00000534820	H0YDR6
ENSG00000109991	ENST00000616487	A0A087X210

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Taste transduction	KEGG	ko04742
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Taste transduction	KEGG	hsa04742
Hemostasis	REACTOME	R-HSA-109582
Platelet homeostasis	REACTOME	R-HSA-418346
Platelet calcium homeostasis	REACTOME	R-HSA-418360
Elevation of cytosolic Ca2+ levels	REACTOME	R-HSA-139853

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
27626375	2016	X-ray structures define human P2X(3) receptor gating cycle and antagonist action.	54
20308565	2010	ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell.	47
12885270	2003	Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain.	26
20699225	2010	Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP: chimeras and point mutants identify intracellular amino-terminal residues involved in lipid regulation of P2X1 receptors.	22
19960242	2010	The Cdk5 kinase downregulates ATP-gated ionotropic P2X3 receptor function via serine phosphorylation.	19
23959888	2013	Subtype-specific control of P2X receptor channel signaling by ATP and Mg2+.	17
14520770	2003	Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp.	16
15475563	2004	Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites.	16
17052768	2007	Protein kinase C regulation of P2X3 receptors is unlikely to involve direct receptor phosphorylation.	16
21098022	2011	Amino acid residues constituting the agonist binding site of the human P2X3 receptor.	16

Citation

Dessen P

P2RX3 (purinergic receptor P2X 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56601/p2rx3