Atlas of Genetics and Cytogenetics in Oncology and Haematology


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P2RX5 (purinergic receptor P2X 5)

Identity

Alias_namespurinergic receptor P2X
Alias_symbol (synonym)P2X5
LRH-1
Other aliasP2X5R
HGNC (Hugo) P2RX5
LocusID (NCBI) 5026
Atlas_Id 46407
Location 17p13.2  [Link to chromosome band 17p13]
Location_base_pair Starts at 3673228 and ends at 3696404 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKT3 (1q43) / P2RX5 (17p13.2)DLG1 (3q29) / P2RX5 (17p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)P2RX5   8536
Cards
Entrez_Gene (NCBI)P2RX5  5026  purinergic receptor P2X 5
AliasesLRH-1; P2X5; P2X5R
GeneCards (Weizmann)P2RX5
Ensembl hg19 (Hinxton)ENSG00000083454 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000083454 [Gene_View]  chr17:3673228-3696404 [Contig_View]  P2RX5 [Vega]
ICGC DataPortalENSG00000083454
TCGA cBioPortalP2RX5
AceView (NCBI)P2RX5
Genatlas (Paris)P2RX5
WikiGenes5026
SOURCE (Princeton)P2RX5
Genetics Home Reference (NIH)P2RX5
Genomic and cartography
GoldenPath hg38 (UCSC)P2RX5  -     chr17:3673228-3696404 -  17p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)P2RX5  -     17p13.2   [Description]    (hg19-Feb_2009)
EnsemblP2RX5 - 17p13.2 [CytoView hg19]  P2RX5 - 17p13.2 [CytoView hg38]
Mapping of homologs : NCBIP2RX5 [Mapview hg19]  P2RX5 [Mapview hg38]
OMIM602836   
Gene and transcription
Genbank (Entrez)AA805176 AF016709 AF070573 AK092966 AK290889
RefSeq transcript (Entrez)NM_001204519 NM_001204520 NM_002561 NM_175080 NM_175081
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)P2RX5
Cluster EST : UnigeneHs.731607 [ NCBI ]
CGAP (NCI)Hs.731607
Alternative Splicing GalleryENSG00000083454
Gene ExpressionP2RX5 [ NCBI-GEO ]   P2RX5 [ EBI - ARRAY_EXPRESS ]   P2RX5 [ SEEK ]   P2RX5 [ MEM ]
Gene Expression Viewer (FireBrowse)P2RX5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5026
GTEX Portal (Tissue expression)P2RX5
Human Protein AtlasENSG00000083454-P2RX5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ93086   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ93086  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ93086
Splice isoforms : SwissVarQ93086
PhosPhoSitePlusQ93086
Domaine pattern : Prosite (Expaxy)P2X_RECEPTOR (PS01212)   
Domains : Interpro (EBI)P2X5_purnocptor    P2X_extracellular_dom    P2X_purnocptor   
Domain families : Pfam (Sanger)P2X_receptor (PF00864)   
Domain families : Pfam (NCBI)pfam00864   
Conserved Domain (NCBI)P2RX5
DMDM Disease mutations5026
Blocks (Seattle)P2RX5
SuperfamilyQ93086
Human Protein Atlas [tissue]ENSG00000083454-P2RX5 [tissue]
Peptide AtlasQ93086
HPRD09110
IPIIPI00873205   IPI00914060   IPI00789729   IPI01021942   IPI01008926   IPI01021716   IPI01021360   IPI01022089   IPI00217666   
Protein Interaction databases
DIP (DOE-UCLA)Q93086
IntAct (EBI)Q93086
FunCoupENSG00000083454
BioGRIDP2RX5
STRING (EMBL)P2RX5
ZODIACP2RX5
Ontologies - Pathways
QuickGOQ93086
Ontology : AmiGOpurinergic nucleotide receptor activity  purinergic nucleotide receptor activity  transmembrane signaling receptor activity  extracellular ATP-gated cation channel activity  extracellular ATP-gated cation channel activity  ion channel activity  ATP binding  integral component of nuclear inner membrane  cytosol  plasma membrane  integral component of plasma membrane  transport  signal transduction  nervous system development  blood coagulation  positive regulation of calcium ion transport into cytosol  response to ATP  purinergic nucleotide receptor signaling pathway  positive regulation of calcium-mediated signaling  excitatory postsynaptic potential  cation transmembrane transport  postsynapse  
Ontology : EGO-EBIpurinergic nucleotide receptor activity  purinergic nucleotide receptor activity  transmembrane signaling receptor activity  extracellular ATP-gated cation channel activity  extracellular ATP-gated cation channel activity  ion channel activity  ATP binding  integral component of nuclear inner membrane  cytosol  plasma membrane  integral component of plasma membrane  transport  signal transduction  nervous system development  blood coagulation  positive regulation of calcium ion transport into cytosol  response to ATP  purinergic nucleotide receptor signaling pathway  positive regulation of calcium-mediated signaling  excitatory postsynaptic potential  cation transmembrane transport  postsynapse  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction   
NDEx NetworkP2RX5
Atlas of Cancer Signalling NetworkP2RX5
Wikipedia pathwaysP2RX5
Orthology - Evolution
OrthoDB5026
GeneTree (enSembl)ENSG00000083454
Phylogenetic Trees/Animal Genes : TreeFamP2RX5
HOVERGENQ93086
HOGENOMQ93086
Homologs : HomoloGeneP2RX5
Homology/Alignments : Family Browser (UCSC)P2RX5
Gene fusions - Rearrangements
Tumor Fusion PortalP2RX5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerP2RX5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)P2RX5
dbVarP2RX5
ClinVarP2RX5
1000_GenomesP2RX5 
Exome Variant ServerP2RX5
ExAC (Exome Aggregation Consortium)ENSG00000083454
GNOMAD BrowserENSG00000083454
Genetic variants : HAPMAP5026
Genomic Variants (DGV)P2RX5 [DGVbeta]
DECIPHERP2RX5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisP2RX5 
Mutations
ICGC Data PortalP2RX5 
TCGA Data PortalP2RX5 
Broad Tumor PortalP2RX5
OASIS PortalP2RX5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICP2RX5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDP2RX5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch P2RX5
DgiDB (Drug Gene Interaction Database)P2RX5
DoCM (Curated mutations)P2RX5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)P2RX5 (select a term)
intoGenP2RX5
Cancer3DP2RX5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602836   
Orphanet
DisGeNETP2RX5
MedgenP2RX5
Genetic Testing Registry P2RX5
NextProtQ93086 [Medical]
TSGene5026
GENETestsP2RX5
Target ValidationP2RX5
Huge Navigator P2RX5 [HugePedia]
snp3D : Map Gene to Disease5026
BioCentury BCIQP2RX5
ClinGenP2RX5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5026
Chemical/Pharm GKB GenePA32865
Clinical trialP2RX5
Miscellaneous
canSAR (ICR)P2RX5 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineP2RX5
EVEXP2RX5
GoPubMedP2RX5
iHOPP2RX5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 21 14:27:31 CET 2017

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