P2RY11 (purinergic receptor P2Y11)

2014-10-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
P2Y11
FUSION GENES

Other Information

Locus ID:

NCBI: 5032
MIM: 602697
HGNC: 8540
Ensembl: ENSG00000244165

Variants:

dbSNP: 5032
ClinVar: 5032
TCGA: ENSG00000244165
COSMIC: P2RY11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000244165ENST00000321826Q96G91

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
P2Y receptorsREACTOMER-HSA-417957
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
211700442011Common variants in P2RY11 are associated with narcolepsy.59
169261522006Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes.48
116906422001Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.41
180564022007Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.37
235770752013Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor.33
178248412008Hetero-oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptor.24
209645982011Regulation of human mesenchymal stem cell functions by an autocrine loop involving NAD+ release and P2Y11-mediated signaling.22
275868462016Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling.19
171352832007Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11.16
177075042008NAADP+ is an agonist of the human P2Y11 purinergic receptor.16

Citation

Dessen P

P2RY11 (purinergic receptor P2Y11)

Atlas Genet Cytogenet Oncol Haematol. 2014-10-01

Online version: http://atlasgeneticsoncology.org/gene/54919/p2ry11