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P2RY12 (purinergic receptor P2Y12)

Identity

Alias_namespurinergic receptor P2Y
Alias_symbol (synonym)P2Y12
SP1999
HORK3
Other aliasADPG-R
BDPLT8
P2T(AC)
P2Y(12)R
P2Y(AC)
P2Y(ADP)
P2Y(cyc)
HGNC (Hugo) P2RY12
LocusID (NCBI) 64805
Atlas_Id 53601
Location 3q25.1  [Link to chromosome band 3q25]
Location_base_pair Starts at 151336843 and ends at 151384812 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)P2RY12   18124
LRG (Locus Reference Genomic)LRG_569
Cards
Entrez_Gene (NCBI)P2RY12  64805  purinergic receptor P2Y12
AliasesADPG-R; BDPLT8; HORK3; P2T(AC); 
P2Y(12)R; P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; SP1999
GeneCards (Weizmann)P2RY12
Ensembl hg19 (Hinxton)ENSG00000169313 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169313 [Gene_View]  chr3:151336843-151384812 [Contig_View]  P2RY12 [Vega]
ICGC DataPortalENSG00000169313
TCGA cBioPortalP2RY12
AceView (NCBI)P2RY12
Genatlas (Paris)P2RY12
WikiGenes64805
SOURCE (Princeton)P2RY12
Genetics Home Reference (NIH)P2RY12
Genomic and cartography
GoldenPath hg38 (UCSC)P2RY12  -     chr3:151336843-151384812 -  3q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)P2RY12  -     3q25.1   [Description]    (hg19-Feb_2009)
EnsemblP2RY12 - 3q25.1 [CytoView hg19]  P2RY12 - 3q25.1 [CytoView hg38]
Mapping of homologs : NCBIP2RY12 [Mapview hg19]  P2RY12 [Mapview hg38]
OMIM600515   609821   
Gene and transcription
Genbank (Entrez)AA810452 AB052684 AF313449 AF321815 AJ320495
RefSeq transcript (Entrez)NM_022788 NM_176876
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)P2RY12
Cluster EST : UnigeneHs.665544 [ NCBI ]
CGAP (NCI)Hs.665544
Alternative Splicing GalleryENSG00000169313
Gene ExpressionP2RY12 [ NCBI-GEO ]   P2RY12 [ EBI - ARRAY_EXPRESS ]   P2RY12 [ SEEK ]   P2RY12 [ MEM ]
Gene Expression Viewer (FireBrowse)P2RY12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64805
GTEX Portal (Tissue expression)P2RY12
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H244   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H244  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H244
Splice isoforms : SwissVarQ9H244
PhosPhoSitePlusQ9H244
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    P2Y12_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)P2RY12
DMDM Disease mutations64805
Blocks (Seattle)P2RY12
PDB (SRS)1T78    1VZ1    1Y9C    4NTJ    4PXZ    4PY0   
PDB (PDBSum)1T78    1VZ1    1Y9C    4NTJ    4PXZ    4PY0   
PDB (IMB)1T78    1VZ1    1Y9C    4NTJ    4PXZ    4PY0   
PDB (RSDB)1T78    1VZ1    1Y9C    4NTJ    4PXZ    4PY0   
Structural Biology KnowledgeBase1T78    1VZ1    1Y9C    4NTJ    4PXZ    4PY0   
SCOP (Structural Classification of Proteins)1T78    1VZ1    1Y9C    4NTJ    4PXZ    4PY0   
CATH (Classification of proteins structures)1T78    1VZ1    1Y9C    4NTJ    4PXZ    4PY0   
SuperfamilyQ9H244
Human Protein AtlasENSG00000169313
Peptide AtlasQ9H244
HPRD02743
IPIIPI00009729   IPI00909653   
Protein Interaction databases
DIP (DOE-UCLA)Q9H244
IntAct (EBI)Q9H244
FunCoupENSG00000169313
BioGRIDP2RY12
STRING (EMBL)P2RY12
ZODIACP2RY12
Ontologies - Pathways
QuickGOQ9H244
Ontology : AmiGOG-protein coupled adenosine receptor activity  ADP receptor activity  ADP receptor activity  adenosine receptor signaling pathway  guanyl-nucleotide exchange factor activity  mitochondrion  plasma membrane  plasma membrane  integral component of plasma membrane  caveola  substrate-dependent cell migration, cell extension  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  hemostasis  glial cell migration  external side of plasma membrane  basal plasma membrane  cell surface  negative regulation of norepinephrine secretion  intrinsic component of membrane  G-protein coupled purinergic nucleotide receptor signaling pathway  positive regulation of ion transport  protein kinase B signaling  positive regulation of GTPase activity  negative regulation of cell differentiation  regulation of calcium ion transport  platelet aggregation  calcium ion transmembrane transport  cellular response to ATP  potassium ion transmembrane transport  regulation of microglial cell migration  
Ontology : EGO-EBIG-protein coupled adenosine receptor activity  ADP receptor activity  ADP receptor activity  adenosine receptor signaling pathway  guanyl-nucleotide exchange factor activity  mitochondrion  plasma membrane  plasma membrane  integral component of plasma membrane  caveola  substrate-dependent cell migration, cell extension  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  hemostasis  glial cell migration  external side of plasma membrane  basal plasma membrane  cell surface  negative regulation of norepinephrine secretion  intrinsic component of membrane  G-protein coupled purinergic nucleotide receptor signaling pathway  positive regulation of ion transport  protein kinase B signaling  positive regulation of GTPase activity  negative regulation of cell differentiation  regulation of calcium ion transport  platelet aggregation  calcium ion transmembrane transport  cellular response to ATP  potassium ion transmembrane transport  regulation of microglial cell migration  
NDEx NetworkP2RY12
Atlas of Cancer Signalling NetworkP2RY12
Wikipedia pathwaysP2RY12
Orthology - Evolution
OrthoDB64805
GeneTree (enSembl)ENSG00000169313
Phylogenetic Trees/Animal Genes : TreeFamP2RY12
HOVERGENQ9H244
HOGENOMQ9H244
Homologs : HomoloGeneP2RY12
Homology/Alignments : Family Browser (UCSC)P2RY12
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerP2RY12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)P2RY12
dbVarP2RY12
ClinVarP2RY12
1000_GenomesP2RY12 
Exome Variant ServerP2RY12
ExAC (Exome Aggregation Consortium)P2RY12 (select the gene name)
Genetic variants : HAPMAP64805
Genomic Variants (DGV)P2RY12 [DGVbeta]
DECIPHERP2RY12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisP2RY12 
Mutations
ICGC Data PortalP2RY12 
TCGA Data PortalP2RY12 
Broad Tumor PortalP2RY12
OASIS PortalP2RY12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICP2RY12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDP2RY12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch P2RY12
DgiDB (Drug Gene Interaction Database)P2RY12
DoCM (Curated mutations)P2RY12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)P2RY12 (select a term)
intoGenP2RY12
Cancer3DP2RY12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600515    609821   
Orphanet19394    10417   
MedgenP2RY12
Genetic Testing Registry P2RY12
NextProtQ9H244 [Medical]
TSGene64805
GENETestsP2RY12
Target ValidationP2RY12
Huge Navigator P2RY12 [HugePedia]
snp3D : Map Gene to Disease64805
BioCentury BCIQP2RY12
ClinGenP2RY12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64805
Chemical/Pharm GKB GenePA134971947
Clinical trialP2RY12
Miscellaneous
canSAR (ICR)P2RY12 (select the gene name)
Probes
Litterature
PubMed178 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineP2RY12
EVEXP2RY12
GoPubMedP2RY12
iHOPP2RY12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:02:29 CEST 2017

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