P2RY14 (purinergic receptor P2Y14)

2014-11-01  

Identity

HGNC
LOCATION
3q25.1
LOCUSID
ALIAS
BPR105,GPR105,P2Y14

Other Information

Locus ID:

NCBI: 9934
MIM: 610116
HGNC: 16442
Ensembl: ENSG00000174944

Variants:

dbSNP: 9934
ClinVar: 9934
TCGA: ENSG00000174944
COSMIC: P2RY14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174944ENST00000309170Q15391
ENSG00000174944ENST00000309170A5JUU3
ENSG00000174944ENST00000424796Q15391
ENSG00000174944ENST00000424796A5JUU3
ENSG00000174944ENST00000494668C9JAB5

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
P2Y receptorsREACTOMER-HSA-417957
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125597632003Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family.110
129024972003Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose.38
128429112003P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells.35
194547052009The UDP-glucose receptor P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8.29
235925142013A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.29
226736222012The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils.18
248470572014Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes.15
186903462008Detection of P2Y(14) protein in platelets and investigation of the role of P2Y(14) in platelet function in comparison with the EP(3) receptor.8
277329652016Nucleoside 5'-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation.2
288041252017The expression of P2Y14, a purinergic G-protein coupled receptor, defines functionally distinct subpopulations in placenta-derived hematopoietic stem progenitor cells.0

Citation

Dessen P

P2RY14 (purinergic receptor P2Y14)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71607/p2ry14