| Nomenclature |
|---|
| HGNC (Hugo) | P2RY6 8543 |
| Cards |
|---|
| Entrez_Gene (NCBI) | P2RY6 5031 pyrimidinergic receptor P2Y6 |
| Aliases | P2Y6 |
| GeneCards (Weizmann) | P2RY6 |
| Ensembl hg19 (Hinxton) | ENSG00000171631 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000171631 [Gene_View] ENSG00000171631 [Sequence] chr11:73269894-73298625 [Contig_View] P2RY6 [Vega] |
| ICGC DataPortal | ENSG00000171631 |
| TCGA cBioPortal | P2RY6 |
| AceView (NCBI) | P2RY6 |
| Genatlas (Paris) | P2RY6 |
| WikiGenes | 5031 |
| SOURCE (Princeton) | P2RY6 |
| Genetics Home Reference (NIH) | P2RY6 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | P2RY6 - chr11:73269894-73298625 + 11q13.4 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | P2RY6 - 11q13.4 [Description] (hg19-Feb_2009) |
P2RY6 - 11q13.4 [CytoView hg19] P2RY6 - 11q13.4 [CytoView hg38] |
| Mapping of homologs : NCBI | P2RY6 [Mapview hg19] P2RY6 [Mapview hg38] |
| OMIM | 602451 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF007891 AF007892 AF007893 AF218005 AF498920 |
| RefSeq transcript (Entrez) | NM_001277204 NM_001277205 NM_001277206 NM_001277207 NM_001277208 NM_004154 NM_176796 NM_176797 NM_176798 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | P2RY6 |
| Cluster EST : Unigene | Hs.16362 [ NCBI ] |
| CGAP (NCI) | Hs.16362 |
| Alternative Splicing Gallery | ENSG00000171631 |
| Gene Expression | P2RY6 [ NCBI-GEO ] P2RY6 [ EBI - ARRAY_EXPRESS ]
P2RY6 [ SEEK ] P2RY6 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | P2RY6 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5031 |
| GTEX Portal (Tissue expression) | P2RY6 |
| Human Protein Atlas | ENSG00000171631-P2RY6 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q15077 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q15077 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q15077 |
| Splice isoforms : SwissVar | Q15077 |
| PhosPhoSitePlus | Q15077 |
| Domaine pattern : Prosite (Expaxy) | G_PROTEIN_RECEP_F1_2 (PS50262) |
| Domains : Interpro (EBI) | GPCR_Rhodpsn GPCR_Rhodpsn_7TM P2Y6_rcpt |
| Domain families : Pfam (Sanger) | 7tm_1 (PF00001) |
| Domain families : Pfam (NCBI) | pfam00001 |
| Conserved Domain (NCBI) | P2RY6 |
| DMDM Disease mutations | 5031 |
| Blocks (Seattle) | P2RY6 |
| PDB (RSDB) | 2B6R |
| PDB Europe | 2B6R |
| PDB (PDBSum) | 2B6R |
| PDB (IMB) | 2B6R |
| Structural Biology KnowledgeBase | 2B6R |
| SCOP (Structural Classification of Proteins) | 2B6R |
| CATH (Classification of proteins structures) | 2B6R |
| Superfamily | Q15077 |
| Human Protein Atlas [tissue] | ENSG00000171631-P2RY6 [tissue] |
| Peptide Atlas | Q15077 |
| HPRD | 03906 |
| IPI | IPI00014315 IPI01013029 IPI01011114 IPI01011769 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q15077 |
| IntAct (EBI) | Q15077 |
| FunCoup | ENSG00000171631 |
| BioGRID | P2RY6 |
| STRING (EMBL) | P2RY6 |
| ZODIAC | P2RY6 |
| Ontologies - Pathways |
|---|
| QuickGO | Q15077 |
| Ontology : AmiGO | ADP receptor activity G protein-coupled receptor activity protein binding plasma membrane plasma membrane integral component of plasma membrane phagocytosis G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway activation of phospholipase C activity positive regulation of smooth muscle cell migration basolateral plasma membrane apical plasma membrane transepithelial chloride transport positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity positive regulation of inositol trisphosphate biosynthetic process positive regulation of inositol trisphosphate biosynthetic process G protein-coupled purinergic nucleotide receptor signaling pathway UDP-activated nucleotide receptor activity UTP-activated nucleotide receptor activity positive regulation of ERK1 and ERK2 cascade cellular response to prostaglandin E stimulus cellular response to purine-containing compound positive regulation of vascular smooth muscle cell proliferation cellular response to pyrimidine ribonucleotide cellular response to pyrimidine ribonucleotide |
| Ontology : EGO-EBI | ADP receptor activity G protein-coupled receptor activity protein binding plasma membrane plasma membrane integral component of plasma membrane phagocytosis G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway activation of phospholipase C activity positive regulation of smooth muscle cell migration basolateral plasma membrane apical plasma membrane transepithelial chloride transport positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity positive regulation of inositol trisphosphate biosynthetic process positive regulation of inositol trisphosphate biosynthetic process G protein-coupled purinergic nucleotide receptor signaling pathway UDP-activated nucleotide receptor activity UTP-activated nucleotide receptor activity positive regulation of ERK1 and ERK2 cascade cellular response to prostaglandin E stimulus cellular response to purine-containing compound positive regulation of vascular smooth muscle cell proliferation cellular response to pyrimidine ribonucleotide cellular response to pyrimidine ribonucleotide |
| Pathways : KEGG | Neuroactive ligand-receptor interaction |
| NDEx Network | P2RY6 |
| Atlas of Cancer Signalling Network | P2RY6 |
| Wikipedia pathways | P2RY6 |
| Orthology - Evolution |
|---|
| OrthoDB | 5031 |
| GeneTree (enSembl) | ENSG00000171631 |
| Phylogenetic Trees/Animal Genes : TreeFam | P2RY6 |
| HOGENOM | Q15077 |
| Homologs : HomoloGene | P2RY6 |
| Homology/Alignments : Family Browser (UCSC) | P2RY6 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | C2CD3/P2RY6 [11q13.4/11q13.4] [t(11;11)(q13;q13)] |
| Fusion Portal | C2CD3 11q13.4 P2RY6 11q13.4 BRCA |
| Fusion : Quiver | P2RY6 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | P2RY6 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | P2RY6 |
| dbVar | P2RY6 |
| ClinVar | P2RY6 |
| 1000_Genomes | P2RY6 |
| Exome Variant Server | P2RY6 |
| ExAC (Exome Aggregation Consortium) | ENSG00000171631 |
| GNOMAD Browser | ENSG00000171631 |
| Varsome Browser | P2RY6 |
| Genetic variants : HAPMAP | 5031 |
| Genomic Variants (DGV) | P2RY6 [DGVbeta] |
| DECIPHER | P2RY6 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | P2RY6 |
| Mutations |
|---|
| ICGC Data Portal | P2RY6 |
| TCGA Data Portal | P2RY6 |
| Broad Tumor Portal | P2RY6 |
| OASIS Portal | P2RY6 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | P2RY6 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | P2RY6 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search P2RY6 |
| DgiDB (Drug Gene Interaction Database) | P2RY6 |
| DoCM (Curated mutations) | P2RY6 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | P2RY6 (select a term) |
| intoGen | P2RY6 |
| Cancer3D | P2RY6(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602451 |
| Orphanet | |
| DisGeNET | P2RY6 |
| Medgen | P2RY6 |
| Genetic Testing Registry | P2RY6
|
| NextProt | Q15077 [Medical] |
| TSGene | 5031 |
| GENETests | P2RY6 |
| Target Validation | P2RY6 |
| Huge Navigator |
P2RY6 [HugePedia] |
| snp3D : Map Gene to Disease | 5031 |
| BioCentury BCIQ | P2RY6 |
| ClinGen | P2RY6 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 5031 |
| Chemical/Pharm GKB Gene | PA32872 |
| Clinical trial | P2RY6 |
| Miscellaneous |
|---|
| canSAR (ICR) | P2RY6 (select the gene name) |
| DataMed Index | P2RY6 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 48 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | P2RY6 |
| EVEX | P2RY6 |
| GoPubMed | P2RY6 |
| iHOP | P2RY6 |
