Atlas of Genetics and Cytogenetics in Oncology and Haematology

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P2RY6 (pyrimidinergic receptor P2Y6)

Identity

Alias_namespyrimidinergic receptor P2Y
Alias_symbol (synonym)P2Y6
Other alias
HGNC (Hugo) P2RY6
LocusID (NCBI) 5031
Atlas_Id 46309
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 73269894 and ends at 73298625 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C2CD3 (11q13.4) / P2RY6 (11q13.4)C2CD3 11q13.4 / P2RY6 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q13;q13) C2CD3/P2RY6

External links

Nomenclature
HGNC (Hugo)P2RY6   8543
Cards
Entrez_Gene (NCBI)P2RY6  5031  pyrimidinergic receptor P2Y6
AliasesP2Y6
GeneCards (Weizmann)P2RY6
Ensembl hg19 (Hinxton)ENSG00000171631 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171631 [Gene_View]ENSG00000171631 [Sequence]  chr11:73269894-73298625 [Contig_View]  P2RY6 [Vega]
ICGC DataPortalENSG00000171631
TCGA cBioPortalP2RY6
AceView (NCBI)P2RY6
Genatlas (Paris)P2RY6
WikiGenes5031
SOURCE (Princeton)P2RY6
Genetics Home Reference (NIH)P2RY6
Genomic and cartography
GoldenPath hg38 (UCSC)P2RY6  -     chr11:73269894-73298625 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)P2RY6  -     11q13.4   [Description]    (hg19-Feb_2009)
EnsemblP2RY6 - 11q13.4 [CytoView hg19]  P2RY6 - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBIP2RY6 [Mapview hg19]  P2RY6 [Mapview hg38]
OMIM602451   
Gene and transcription
Genbank (Entrez)AF007891 AF007892 AF007893 AF218005 AF498920
RefSeq transcript (Entrez)NM_001277204 NM_001277205 NM_001277206 NM_001277207 NM_001277208 NM_004154 NM_176796 NM_176797 NM_176798
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)P2RY6
Cluster EST : UnigeneHs.16362 [ NCBI ]
CGAP (NCI)Hs.16362
Alternative Splicing GalleryENSG00000171631
Gene ExpressionP2RY6 [ NCBI-GEO ]   P2RY6 [ EBI - ARRAY_EXPRESS ]   P2RY6 [ SEEK ]   P2RY6 [ MEM ]
Gene Expression Viewer (FireBrowse)P2RY6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5031
GTEX Portal (Tissue expression)P2RY6
Human Protein AtlasENSG00000171631-P2RY6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15077   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15077  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15077
Splice isoforms : SwissVarQ15077
PhosPhoSitePlusQ15077
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    P2Y6_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)P2RY6
DMDM Disease mutations5031
Blocks (Seattle)P2RY6
PDB (SRS)2B6R   
PDB (PDBSum)2B6R   
PDB (IMB)2B6R   
PDB (RSDB)2B6R   
Structural Biology KnowledgeBase2B6R   
SCOP (Structural Classification of Proteins)2B6R   
CATH (Classification of proteins structures)2B6R   
SuperfamilyQ15077
Human Protein Atlas [tissue]ENSG00000171631-P2RY6 [tissue]
Peptide AtlasQ15077
HPRD03906
IPIIPI00014315   IPI01013029   IPI01011114   IPI01011769   
Protein Interaction databases
DIP (DOE-UCLA)Q15077
IntAct (EBI)Q15077
FunCoupENSG00000171631
BioGRIDP2RY6
STRING (EMBL)P2RY6
ZODIACP2RY6
Ontologies - Pathways
QuickGOQ15077
Ontology : AmiGOG-protein coupled receptor activity  protein binding  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of smooth muscle cell migration  basolateral plasma membrane  apical plasma membrane  transepithelial chloride transport  G-protein coupled purinergic nucleotide receptor signaling pathway  G-protein coupled purinergic nucleotide receptor activity  UDP-activated nucleotide receptor activity  cellular response to prostaglandin E stimulus  cellular response to organic cyclic compound  
Ontology : EGO-EBIG-protein coupled receptor activity  protein binding  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of smooth muscle cell migration  basolateral plasma membrane  apical plasma membrane  transepithelial chloride transport  G-protein coupled purinergic nucleotide receptor signaling pathway  G-protein coupled purinergic nucleotide receptor activity  UDP-activated nucleotide receptor activity  cellular response to prostaglandin E stimulus  cellular response to organic cyclic compound  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkP2RY6
Atlas of Cancer Signalling NetworkP2RY6
Wikipedia pathwaysP2RY6
Orthology - Evolution
OrthoDB5031
GeneTree (enSembl)ENSG00000171631
Phylogenetic Trees/Animal Genes : TreeFamP2RY6
HOVERGENQ15077
HOGENOMQ15077
Homologs : HomoloGeneP2RY6
Homology/Alignments : Family Browser (UCSC)P2RY6
Gene fusions - Rearrangements
Fusion : MitelmanC2CD3/P2RY6 [11q13.4/11q13.4]  [t(11;11)(q13;q13)]  
Fusion PortalC2CD3 11q13.4 P2RY6 11q13.4 BRCA
Fusion : QuiverP2RY6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerP2RY6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)P2RY6
dbVarP2RY6
ClinVarP2RY6
1000_GenomesP2RY6 
Exome Variant ServerP2RY6
ExAC (Exome Aggregation Consortium)ENSG00000171631
GNOMAD BrowserENSG00000171631
Genetic variants : HAPMAP5031
Genomic Variants (DGV)P2RY6 [DGVbeta]
DECIPHERP2RY6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisP2RY6 
Mutations
ICGC Data PortalP2RY6 
TCGA Data PortalP2RY6 
Broad Tumor PortalP2RY6
OASIS PortalP2RY6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICP2RY6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDP2RY6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch P2RY6
DgiDB (Drug Gene Interaction Database)P2RY6
DoCM (Curated mutations)P2RY6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)P2RY6 (select a term)
intoGenP2RY6
Cancer3DP2RY6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602451   
Orphanet
DisGeNETP2RY6
MedgenP2RY6
Genetic Testing Registry P2RY6
NextProtQ15077 [Medical]
TSGene5031
GENETestsP2RY6
Target ValidationP2RY6
Huge Navigator P2RY6 [HugePedia]
snp3D : Map Gene to Disease5031
BioCentury BCIQP2RY6
ClinGenP2RY6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5031
Chemical/Pharm GKB GenePA32872
Clinical trialP2RY6
Miscellaneous
canSAR (ICR)P2RY6 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineP2RY6
EVEXP2RY6
GoPubMedP2RY6
iHOPP2RY6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jun 21 17:06:44 CEST 2018
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