P4HA1 (prolyl 4-hydroxylase subunit alpha 1)

2007-02-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
P4HA
FUSION GENES

Other Information

Locus ID:

NCBI: 5033
MIM: 176710
HGNC: 8546
Ensembl: ENSG00000122884

Variants:

dbSNP: 5033
ClinVar: 5033
TCGA: ENSG00000122884
COSMIC: P4HA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122884ENST00000263556P13674
ENSG00000122884ENST00000263556Q5VSQ6
ENSG00000122884ENST00000307116P13674
ENSG00000122884ENST00000373008P13674
ENSG00000122884ENST00000373008Q5VSQ6
ENSG00000122884ENST00000394890P13674
ENSG00000122884ENST00000440381P13674

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Collagen biosynthesis and modifying enzymesREACTOMER-HSA-1650814

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
234233822013Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts.136
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
231787102013miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression.58
168851642006The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases.38
168773512006Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels.29
168374612006Translational control of collagen prolyl 4-hydroxylase-alpha(I) gene expression under hypoxia.28
251153932014The miR-124-prolyl hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression.27
303670422018Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance.24
164648612006Heterogeneous nuclear ribonucleoprotein-A2/B1 modulate collagen prolyl 4-hydroxylase, alpha (I) mRNA stability.18

Citation

Dessen P

P4HA1 (prolyl 4-hydroxylase subunit alpha 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46330/p4ha1