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PABPC1L (poly(A) binding protein cytoplasmic 1 like)

Identity

Alias (NCBI)C20orf119
EPAB
PABPC1L1
dJ1069P2.3
HGNC (Hugo) PABPC1L
HGNC Alias symbdJ1069P2.3
PABPC1L1
ePAB
HGNC Previous nameC20orf119
HGNC Previous namechromosome 20 open reading frame 119
 poly(A) binding protein, cytoplasmic 1-like
LocusID (NCBI) 80336
Atlas_Id 71612
Location 20q13.12  [Link to chromosome band 20q13]
Location_base_pair Starts at 44910060 and ends at 44939316 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GAS5 (1q25.1) / PABPC1L (20q13.12)MIA3 (1q41) / PABPC1L (20q13.12)PABPC1L (20q13.12) / CPNE7 (16q24.3)
PABPC1L (20q13.12) / LUM (12q21.33)PABPC1L (20q13.12) / MRPL39 (21q21.3)PABPC1L (20q13.12) / YWHAB (20q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(20;20)(q13;q13) PABPC1L/YWHAB
t(20;20)(q13;q13) PABPC1L/YWHAB


External links

 

Nomenclature
HGNC (Hugo)PABPC1L   15797
Cards
Entrez_Gene (NCBI)PABPC1L    poly(A) binding protein cytoplasmic 1 like
AliasesC20orf119; EPAB; PABPC1L1; dJ1069P2.3
GeneCards (Weizmann)PABPC1L
Ensembl hg19 (Hinxton)ENSG00000101104 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101104 [Gene_View]  ENSG00000101104 [Sequence]  chr20:44910060-44939316 [Contig_View]  PABPC1L [Vega]
ICGC DataPortalENSG00000101104
TCGA cBioPortalPABPC1L
AceView (NCBI)PABPC1L
Genatlas (Paris)PABPC1L
SOURCE (Princeton)PABPC1L
Genetics Home Reference (NIH)PABPC1L
Genomic and cartography
GoldenPath hg38 (UCSC)PABPC1L  -     chr20:44910060-44939316 +  20q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PABPC1L  -     20q13.12   [Description]    (hg19-Feb_2009)
GoldenPathPABPC1L - 20q13.12 [CytoView hg19]  PABPC1L - 20q13.12 [CytoView hg38]
ImmunoBaseENSG00000101104
Genome Data Viewer NCBIPABPC1L [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AI597906 AK021902 AK026760 AK055371 AK124047
RefSeq transcript (Entrez)NM_001124756 NM_001372179
Consensus coding sequences : CCDS (NCBI)PABPC1L
Gene ExpressionPABPC1L [ NCBI-GEO ]   PABPC1L [ EBI - ARRAY_EXPRESS ]   PABPC1L [ SEEK ]   PABPC1L [ MEM ]
Gene Expression Viewer (FireBrowse)PABPC1L [ Firebrowse - Broad ]
GenevisibleExpression of PABPC1L in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80336
GTEX Portal (Tissue expression)PABPC1L
Human Protein AtlasENSG00000101104-PABPC1L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4VXU2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4VXU2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4VXU2
PhosPhoSitePlusQ4VXU2
Domaine pattern : Prosite (Expaxy)PABC (PS51309)    RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    PABP-dom    PABP_1234    PABP_HYD    RBD_domain_sf    RRM_dom    RRM_dom_euk   
Domain families : Pfam (Sanger)PABP (PF00658)    RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00658    pfam00076   
Domain families : Smart (EMBL)PolyA (SM00517)  RRM (SM00360)  RRM_1 (SM00361)  
Conserved Domain (NCBI)PABPC1L
SuperfamilyQ4VXU2
AlphaFold pdb e-kbQ4VXU2   
Human Protein Atlas [tissue]ENSG00000101104-PABPC1L [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q4VXU2
IntAct (EBI)Q4VXU2
BioGRIDPABPC1L
STRING (EMBL)PABPC1L
ZODIACPABPC1L
Ontologies - Pathways
QuickGOQ4VXU2
Ontology : AmiGORNA binding  mRNA 3'-UTR binding  nucleus  cytosol  poly(A) binding  poly(U) RNA binding  cytoplasmic stress granule  extracellular exosome  ribonucleoprotein complex  
Ontology : EGO-EBIRNA binding  mRNA 3'-UTR binding  nucleus  cytosol  poly(A) binding  poly(U) RNA binding  cytoplasmic stress granule  extracellular exosome  ribonucleoprotein complex  
NDEx NetworkPABPC1L
Atlas of Cancer Signalling NetworkPABPC1L
Wikipedia pathwaysPABPC1L
Orthology - Evolution
OrthoDB80336
GeneTree (enSembl)ENSG00000101104
Phylogenetic Trees/Animal Genes : TreeFamPABPC1L
Homologs : HomoloGenePABPC1L
Homology/Alignments : Family Browser (UCSC)PABPC1L
Gene fusions - Rearrangements
Fusion : QuiverPABPC1L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPABPC1L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PABPC1L
dbVarPABPC1L
ClinVarPABPC1L
MonarchPABPC1L
1000_GenomesPABPC1L 
Exome Variant ServerPABPC1L
GNOMAD BrowserENSG00000101104
Varsome BrowserPABPC1L
ACMGPABPC1L variants
VarityQ4VXU2
Genomic Variants (DGV)PABPC1L [DGVbeta]
DECIPHERPABPC1L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPABPC1L 
Mutations
ICGC Data PortalPABPC1L 
TCGA Data PortalPABPC1L 
Broad Tumor PortalPABPC1L
OASIS PortalPABPC1L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPABPC1L  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPABPC1L
Mutations and Diseases : HGMDPABPC1L
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPABPC1L
DgiDB (Drug Gene Interaction Database)PABPC1L
DoCM (Curated mutations)PABPC1L
CIViC (Clinical Interpretations of Variants in Cancer)PABPC1L
Cancer3DPABPC1L
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPABPC1L
MedgenPABPC1L
Genetic Testing Registry PABPC1L
NextProtQ4VXU2 [Medical]
GENETestsPABPC1L
Target ValidationPABPC1L
Huge Navigator PABPC1L [HugePedia]
ClinGenPABPC1L
Clinical trials, drugs, therapy
MyCancerGenomePABPC1L
Protein Interactions : CTDPABPC1L
Pharm GKB GenePA162398552
PharosQ4VXU2
Clinical trialPABPC1L
Miscellaneous
canSAR (ICR)PABPC1L
HarmonizomePABPC1L
DataMed IndexPABPC1L
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPABPC1L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:15:18 CEST 2021

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