PABPC4 (poly(A) binding protein cytoplasmic 4)

2012-12-01  

Identity

HGNC
LOCATION
1p34.3
LOCUSID
ALIAS
APP-1,APP1,PABP4,iPABP
FUSION GENES

Other Information

Locus ID:

NCBI: 8761
MIM: 603407
HGNC: 8557
Ensembl: ENSG00000090621

Variants:

dbSNP: 8761
ClinVar: 8761
TCGA: ENSG00000090621
COSMIC: PABPC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090621ENST00000372856Q13310
ENSG00000090621ENST00000372857Q13310
ENSG00000090621ENST00000372858Q13310
ENSG00000090621ENST00000372862B1ANR0
ENSG00000090621ENST00000421687H0Y5F5
ENSG00000090621ENST00000437136H0Y6X6
ENSG00000090621ENST00000451091B1ANR1
ENSG00000090621ENST00000470443H0YEQ8
ENSG00000090621ENST00000474378H0YCC8
ENSG00000090621ENST00000527718H0YEU6
ENSG00000090621ENST00000530186H0YER0

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
RNA transportKEGGko03013
RNA transportKEGGhsa03013
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
216464272011Importin alpha-mediated nuclear import of cytoplasmic poly(A) binding protein occurs as a direct consequence of cytoplasmic mRNA depletion.31
219407972011Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs.27
233008562012Depletion of nuclear poly(A) binding protein PABPN1 produces a compensatory response by cytoplasmic PABP4 and PABP5 in cultured human cells.12
228840932012Cytoplasmic poly(A) binding protein 4 is highly expressed in human colorectal cancer and correlates with better prognosis.6
260051592015Gender-specific association between the cytoplasmic poly(A) binding protein 4 rs4660293 single nucleotide polymorphism and serum lipid levels.1

Citation

Dessen P

PABPC4 (poly(A) binding protein cytoplasmic 4)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53118/pabpc4