Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PABPC4 (poly(A) binding protein cytoplasmic 4)

Identity

Alias (NCBI)APP-1
APP1
PABP4
iPABP
HGNC (Hugo) PABPC4
HGNC Alias symbiPABP
APP-1
HGNC Alias nameactivated-platelet protein 1
 Inducible poly(A)-binding protein
HGNC Previous namepoly(A)-binding protein, cytoplasmic 4 (inducible form)
 poly(A) binding protein, cytoplasmic 4 (inducible form)
LocusID (NCBI) 8761
Atlas_Id 53118
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 39560816 and ends at 39576790 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DUSP3 (17q21.31) / PABPC4 (1p34.3)PABPC4 (1p34.3) / COL6A1 (21q22.3)PABPC4 (1p34.3) / GALNT5 (2q24.1)
PFKP (10p15.2) / PABPC4 (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Anaplastic large cell lymphoma, ALK-negative
t(1;19)(p34;p13) PABPC4/TYK2

External links

Nomenclature
HGNC (Hugo)PABPC4   8557
Cards
Entrez_Gene (NCBI)PABPC4    poly(A) binding protein cytoplasmic 4
AliasesAPP-1; APP1; PABP4; iPABP
GeneCards (Weizmann)PABPC4
Ensembl hg19 (Hinxton)ENSG00000090621 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000090621 [Gene_View]  ENSG00000090621 [Sequence]  chr1:39560816-39576790 [Contig_View]  PABPC4 [Vega]
ICGC DataPortalENSG00000090621
TCGA cBioPortalPABPC4
AceView (NCBI)PABPC4
Genatlas (Paris)PABPC4
SOURCE (Princeton)PABPC4
Genetics Home Reference (NIH)PABPC4
Genomic and cartography
GoldenPath hg38 (UCSC)PABPC4  -     chr1:39560816-39576790 -  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PABPC4  -     1p34.3   [Description]    (hg19-Feb_2009)
GoldenPathPABPC4 - 1p34.3 [CytoView hg19]  PABPC4 - 1p34.3 [CytoView hg38]
ImmunoBaseENSG00000090621
genome Data Viewer NCBIPABPC4 [Mapview hg19]  
OMIM603407   
Gene and transcription
Genbank (Entrez)AB208962 AK091110 AK125926 AK222917 BC029969
RefSeq transcript (Entrez)NM_001135653 NM_001135654 NM_003819
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PABPC4
Alternative Splicing GalleryENSG00000090621
Gene ExpressionPABPC4 [ NCBI-GEO ]   PABPC4 [ EBI - ARRAY_EXPRESS ]   PABPC4 [ SEEK ]   PABPC4 [ MEM ]
Gene Expression Viewer (FireBrowse)PABPC4 [ Firebrowse - Broad ]
GenevisibleExpression of PABPC4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8761
GTEX Portal (Tissue expression)PABPC4
Human Protein AtlasENSG00000090621-PABPC4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13310   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13310  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13310
Splice isoforms : SwissVarQ13310
PhosPhoSitePlusQ13310
Domaine pattern : Prosite (Expaxy)PABC (PS51309)    RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    PABP-dom    PABP_1234    PABP_HYD    RBD_domain_sf    RRM_dom    RRM_dom_euk   
Domain families : Pfam (Sanger)PABP (PF00658)    RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00658    pfam00076   
Domain families : Smart (EMBL)PolyA (SM00517)  RRM (SM00360)  RRM_1 (SM00361)  
Conserved Domain (NCBI)PABPC4
Blocks (Seattle)PABPC4
SuperfamilyQ13310
Human Protein Atlas [tissue]ENSG00000090621-PABPC4 [tissue]
Peptide AtlasQ13310
HPRD04557
IPIIPI00012726   IPI00555747   IPI00973757   IPI00979132   IPI00642904   IPI00642944   IPI00644016   IPI00641299   IPI00985001   IPI00983556   IPI00984422   IPI00981184   IPI01012764   
Protein Interaction databases
DIP (DOE-UCLA)Q13310
IntAct (EBI)Q13310
BioGRIDPABPC4
STRING (EMBL)PABPC4
ZODIACPABPC4
Ontologies - Pathways
QuickGOQ13310
Ontology : AmiGORNA binding  RNA binding  mRNA 3'-UTR binding  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  cytosol  cytosol  RNA processing  RNA catabolic process  translation  blood coagulation  poly(A) binding  poly(A) binding  poly(U) RNA binding  poly(U) RNA binding  cytoplasmic stress granule  cytoplasmic stress granule  poly(C) RNA binding  regulation of mRNA stability  myeloid cell development  ribonucleoprotein complex  ribonucleoprotein complex  
Ontology : EGO-EBIRNA binding  RNA binding  mRNA 3'-UTR binding  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  cytosol  cytosol  RNA processing  RNA catabolic process  translation  blood coagulation  poly(A) binding  poly(A) binding  poly(U) RNA binding  poly(U) RNA binding  cytoplasmic stress granule  cytoplasmic stress granule  poly(C) RNA binding  regulation of mRNA stability  myeloid cell development  ribonucleoprotein complex  ribonucleoprotein complex  
Pathways : KEGGRNA transport    mRNA surveillance pathway    RNA degradation   
NDEx NetworkPABPC4
Atlas of Cancer Signalling NetworkPABPC4
Wikipedia pathwaysPABPC4
Orthology - Evolution
OrthoDB8761
GeneTree (enSembl)ENSG00000090621
Phylogenetic Trees/Animal Genes : TreeFamPABPC4
HOGENOMQ13310
Homologs : HomoloGenePABPC4
Homology/Alignments : Family Browser (UCSC)PABPC4
Gene fusions - Rearrangements
Fusion : QuiverPABPC4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPABPC4 [hg38]
dbVarPABPC4
ClinVarPABPC4
MonarchPABPC4
1000_GenomesPABPC4 
Exome Variant ServerPABPC4
GNOMAD BrowserENSG00000090621
Varsome BrowserPABPC4
Genomic Variants (DGV)PABPC4 [DGVbeta]
DECIPHERPABPC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPABPC4 
Mutations
ICGC Data PortalPABPC4 
TCGA Data PortalPABPC4 
Broad Tumor PortalPABPC4
OASIS PortalPABPC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPABPC4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPABPC4
Mutations and Diseases : HGMDPABPC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PABPC4
DgiDB (Drug Gene Interaction Database)PABPC4
DoCM (Curated mutations)PABPC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PABPC4 (select a term)
intoGenPABPC4
Cancer3DPABPC4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603407   
Orphanet
DisGeNETPABPC4
MedgenPABPC4
Genetic Testing Registry PABPC4
NextProtQ13310 [Medical]
GENETestsPABPC4
Target ValidationPABPC4
Huge Navigator PABPC4 [HugePedia]
ClinGenPABPC4
Clinical trials, drugs, therapy
MyCancerGenomePABPC4
Protein Interactions : CTD
Pharm GKB GenePA32883
PharosQ13310
Clinical trialPABPC4
Miscellaneous
canSAR (ICR)PABPC4 (select the gene name)
HarmonizomePABPC4
DataMed IndexPABPC4
Probes
Litterature
PubMed131 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPABPC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:30:16 CET 2021
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