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PACS1 (phosphofurin acidic cluster sorting protein 1)

Identity

Alias_symbol (synonym)FLJ10209
KIAA1175
Other aliasMRD17
SHMS
HGNC (Hugo) PACS1
LocusID (NCBI) 55690
Atlas_Id 54021
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 66070353 and ends at 66244747 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
APBB2 (4p14) / PACS1 (11q13.1)ARAP2 (4p14) / PACS1 (11q13.1)CNIH2 (11q13.2) / PACS1 (11q13.1)
CUZD1 (10q26.13) / PACS1 (11q13.1)DPP3 (11q13.2) / PACS1 (11q13.1)KDM2A (11q13.2) / PACS1 (11q13.1)
KIAA0368 (9q31.3) / PACS1 (11q13.1)KRT5 (12q13.13) / PACS1 (11q13.1)MAPK1 (22q11.21) / PACS1 (11q13.1)
PACS1 (11q13.1) / CDK8 (13q12.13)PACS1 (11q13.1) / KDM2A (11q13.2)PACS1 (11q13.1) / NBEAL1 (2q33.2)
PACS1 (11q13.1) / PACS1 (11q13.1)PACS1 (11q13.1) / ZDHHC24 (11q13.2)PLEKHB1 (11q13.4) / PACS1 (11q13.1)
PTEN (10q23.31) / PACS1 (11q13.1)RBM14 (11q13.2) / PACS1 (11q13.1)SLC22A25 (11q12.3) / PACS1 (11q13.1)
SYT7 (11q12.2) / PACS1 (11q13.1)RBM14 11q13.2 / PACS1 11q13.1DPP3 11q13.2 / PACS1 11q13.1
KDM2A 11q13.2 / PACS1 11q13.1KIAA0368 9q31.3 / PACS1 11q13.1PACS1 11q13.1 / ZDHHC24 11q13.2
PLEKHB1 11q13.4 / PACS1 11q13.1SLC22A25 11q12.3 / PACS1 11q13.1SYT7 11q12.2 / PACS1 11q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PACS1   30032
Cards
Entrez_Gene (NCBI)PACS1  55690  phosphofurin acidic cluster sorting protein 1
AliasesMRD17; SHMS
GeneCards (Weizmann)PACS1
Ensembl hg19 (Hinxton)ENSG00000175115 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175115 [Gene_View]  chr11:66070353-66244747 [Contig_View]  PACS1 [Vega]
ICGC DataPortalENSG00000175115
TCGA cBioPortalPACS1
AceView (NCBI)PACS1
Genatlas (Paris)PACS1
WikiGenes55690
SOURCE (Princeton)PACS1
Genetics Home Reference (NIH)PACS1
Genomic and cartography
GoldenPath hg38 (UCSC)PACS1  -     chr11:66070353-66244747 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PACS1  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblPACS1 - 11q13.1 [CytoView hg19]  PACS1 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIPACS1 [Mapview hg19]  PACS1 [Mapview hg38]
OMIM607492   615009   
Gene and transcription
Genbank (Entrez)AB033001 AK001071 AK056361 AK096644 AK098336
RefSeq transcript (Entrez)NM_018026
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PACS1
Cluster EST : UnigeneHs.644326 [ NCBI ]
CGAP (NCI)Hs.644326
Alternative Splicing GalleryENSG00000175115
Gene ExpressionPACS1 [ NCBI-GEO ]   PACS1 [ EBI - ARRAY_EXPRESS ]   PACS1 [ SEEK ]   PACS1 [ MEM ]
Gene Expression Viewer (FireBrowse)PACS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55690
GTEX Portal (Tissue expression)PACS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6VY07   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6VY07  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6VY07
Splice isoforms : SwissVarQ6VY07
PhosPhoSitePlusQ6VY07
Domains : Interpro (EBI)Phosphofurin_acidic_CS-1   
Domain families : Pfam (Sanger)Pacs-1 (PF10254)   
Domain families : Pfam (NCBI)pfam10254   
Conserved Domain (NCBI)PACS1
DMDM Disease mutations55690
Blocks (Seattle)PACS1
SuperfamilyQ6VY07
Human Protein AtlasENSG00000175115
Peptide AtlasQ6VY07
HPRD06320
IPIIPI00376229   IPI00456262   IPI00921102   IPI00984389   IPI00976621   IPI00983458   IPI00976225   IPI00985260   IPI00975935   IPI00977880   IPI00984957   IPI00984885   
Protein Interaction databases
DIP (DOE-UCLA)Q6VY07
IntAct (EBI)Q6VY07
FunCoupENSG00000175115
BioGRIDPACS1
STRING (EMBL)PACS1
ZODIACPACS1
Ontologies - Pathways
QuickGOQ6VY07
Ontology : AmiGOprotein targeting to Golgi  protein binding  cytosol  viral process  COPI-coated vesicle  ion channel binding  regulation of defense response to virus by virus  protein targeting to plasma membrane  
Ontology : EGO-EBIprotein targeting to Golgi  protein binding  cytosol  viral process  COPI-coated vesicle  ion channel binding  regulation of defense response to virus by virus  protein targeting to plasma membrane  
NDEx NetworkPACS1
Atlas of Cancer Signalling NetworkPACS1
Wikipedia pathwaysPACS1
Orthology - Evolution
OrthoDB55690
GeneTree (enSembl)ENSG00000175115
Phylogenetic Trees/Animal Genes : TreeFamPACS1
HOVERGENQ6VY07
HOGENOMQ6VY07
Homologs : HomoloGenePACS1
Homology/Alignments : Family Browser (UCSC)PACS1
Gene fusions - Rearrangements
Fusion : MitelmanDPP3/PACS1 [11q13.2/11q13.1]  [t(11;11)(q13;q13)]  
Fusion : MitelmanKDM2A/PACS1 [11q13.2/11q13.1]  [t(11;11)(q13;q13)]  
Fusion : MitelmanKIAA0368/PACS1 [9q31.3/11q13.1]  [t(9;11)(q31;q13)]  
Fusion : MitelmanPACS1/ZDHHC24 [11q13.1/11q13.2]  [t(11;11)(q13;q13)]  
Fusion : MitelmanPLEKHB1/PACS1 [11q13.4/11q13.1]  [t(11;11)(q13;q13)]  
Fusion : MitelmanSLC22A25/PACS1 [11q12.3/11q13.1]  [t(11;11)(q12;q13)]  
Fusion : MitelmanSYT7/PACS1 [11q12.2/11q13.1]  [t(11;11)(q12;q13)]  
Fusion: TCGADPP3 11q13.2 PACS1 11q13.1 BRCA
Fusion: TCGAKDM2A 11q13.2 PACS1 11q13.1 KIRC LUAD
Fusion: TCGAKIAA0368 9q31.3 PACS1 11q13.1 BRCA
Fusion: TCGAPACS1 11q13.1 ZDHHC24 11q13.2 BLCA BRCA
Fusion: TCGAPLEKHB1 11q13.4 PACS1 11q13.1 BRCA
Fusion: TCGASLC22A25 11q12.3 PACS1 11q13.1 LUAD
Fusion: TCGASYT7 11q12.2 PACS1 11q13.1 BRCA
Fusion Cancer (Beijing)PTEN [10q23.31]  -  PACS1 [11q13.1]  [FUSC004337]  [FUSC004337]  [FUSC004337]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPACS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PACS1
dbVarPACS1
ClinVarPACS1
1000_GenomesPACS1 
Exome Variant ServerPACS1
ExAC (Exome Aggregation Consortium)PACS1 (select the gene name)
Genetic variants : HAPMAP55690
Genomic Variants (DGV)PACS1 [DGVbeta]
DECIPHERPACS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPACS1 
Mutations
ICGC Data PortalPACS1 
TCGA Data PortalPACS1 
Broad Tumor PortalPACS1
OASIS PortalPACS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPACS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPACS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PACS1
DgiDB (Drug Gene Interaction Database)PACS1
DoCM (Curated mutations)PACS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PACS1 (select a term)
intoGenPACS1
Cancer3DPACS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607492    615009   
Orphanet21910   
MedgenPACS1
Genetic Testing Registry PACS1
NextProtQ6VY07 [Medical]
TSGene55690
GENETestsPACS1
Target ValidationPACS1
Huge Navigator PACS1 [HugePedia]
snp3D : Map Gene to Disease55690
BioCentury BCIQPACS1
ClinGenPACS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55690
Chemical/Pharm GKB GenePA134989529
Clinical trialPACS1
Miscellaneous
canSAR (ICR)PACS1 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePACS1
EVEXPACS1
GoPubMedPACS1
iHOPPACS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:09:57 CEST 2017

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