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PACS1 (phosphofurin acidic cluster sorting protein 1)

Identity

Alias (NCBI)MRD17
SHMS
HGNC (Hugo) PACS1
HGNC Alias symbFLJ10209
KIAA1175
LocusID (NCBI) 55690
Atlas_Id 54021
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 66070272 and ends at 66244744 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
APBB2 (4p14)::PACS1 (11q13.1)ARAP2 (4p14)::PACS1 (11q13.1)CNIH2 (11q13.2)::PACS1 (11q13.1)
CUZD1 (10q26.13)::PACS1 (11q13.1)DPP3 (11q13.2)::PACS1 (11q13.1)KDM2A (11q13.2)::PACS1 (11q13.1)
KIAA0368 (9q31.3)::PACS1 (11q13.1)KRT5 (12q13.13)::PACS1 (11q13.1)MAPK1 (22q11.21)::PACS1 (11q13.1)
PACS1 (11q13.1)::CDK8 (13q12.13)PACS1 (11q13.1)::KDM2A (11q13.2)PACS1 (11q13.1)::NBEAL1 (2q33.2)
PACS1 (11q13.1)::PACS1 (11q13.1)PACS1 (11q13.1)::ZDHHC24 (11q13.2)PLEKHB1 (11q13.4)::PACS1 (11q13.1)
PTEN (10q23.31)::PACS1 (11q13.1)RBM14 (11q13.2)::PACS1 (11q13.1)SLC22A25 (11q12.3)::PACS1 (11q13.1)
SYT7 (11q12.2)::PACS1 (11q13.1)RBM14 11q13.2::PACS1 11q13.1DPP3 11q13.2::PACS1 11q13.1
KDM2A 11q13.2::PACS1 11q13.1KIAA0368 9q31.3::PACS1 11q13.1PACS1 11q13.1::ZDHHC24 11q13.2
PLEKHB1 11q13.4::PACS1 11q13.1SLC22A25 11q12.3::PACS1 11q13.1SYT7 11q12.2::PACS1 11q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PACS1   30032
Cards
Entrez_Gene (NCBI)PACS1    phosphofurin acidic cluster sorting protein 1
AliasesMRD17; SHMS
GeneCards (Weizmann)PACS1
Ensembl hg19 (Hinxton)ENSG00000175115 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175115 [Gene_View]  ENSG00000175115 [Sequence]  chr11:66070272-66244744 [Contig_View]  PACS1 [Vega]
ICGC DataPortalENSG00000175115
TCGA cBioPortalPACS1
AceView (NCBI)PACS1
Genatlas (Paris)PACS1
SOURCE (Princeton)PACS1
Genetics Home Reference (NIH)PACS1
Genomic and cartography
GoldenPath hg38 (UCSC)PACS1  -     chr11:66070272-66244744 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PACS1  -     11q13.1   [Description]    (hg19-Feb_2009)
GoldenPathPACS1 - 11q13.1 [CytoView hg19]  PACS1 - 11q13.1 [CytoView hg38]
ImmunoBaseENSG00000175115
Genome Data Viewer NCBIPACS1 [Mapview hg19]  
OMIM607492   615009   
Gene and transcription
Genbank (Entrez)AB033001 AK001071 AK056361 AK096644 AK098336
RefSeq transcript (Entrez)NM_018026
Consensus coding sequences : CCDS (NCBI)PACS1
Gene ExpressionPACS1 [ NCBI-GEO ]   PACS1 [ EBI - ARRAY_EXPRESS ]   PACS1 [ SEEK ]   PACS1 [ MEM ]
Gene Expression Viewer (FireBrowse)PACS1 [ Firebrowse - Broad ]
GenevisibleExpression of PACS1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55690
GTEX Portal (Tissue expression)PACS1
Human Protein AtlasENSG00000175115-PACS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6VY07   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6VY07  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6VY07
PhosPhoSitePlusQ6VY07
Domains : Interpro (EBI)Phosphofurin_acidic_CS-1   
Domain families : Pfam (Sanger)Pacs-1 (PF10254)   
Domain families : Pfam (NCBI)pfam10254   
Conserved Domain (NCBI)PACS1
SuperfamilyQ6VY07
AlphaFold pdb e-kbQ6VY07   
Human Protein Atlas [tissue]ENSG00000175115-PACS1 [tissue]
HPRD06320
Protein Interaction databases
DIP (DOE-UCLA)Q6VY07
IntAct (EBI)Q6VY07
BioGRIDPACS1
STRING (EMBL)PACS1
ZODIACPACS1
Ontologies - Pathways
QuickGOQ6VY07
Ontology : AmiGOprotein binding  Golgi apparatus  cytosol  COPI-coated vesicle  protein localization to Golgi apparatus  ion channel binding  ion channel binding  regulation of defense response to virus by virus  protein localization to plasma membrane  protein localization to plasma membrane  
Ontology : EGO-EBIprotein binding  Golgi apparatus  cytosol  COPI-coated vesicle  protein localization to Golgi apparatus  ion channel binding  ion channel binding  regulation of defense response to virus by virus  protein localization to plasma membrane  protein localization to plasma membrane  
NDEx NetworkPACS1
Atlas of Cancer Signalling NetworkPACS1
Wikipedia pathwaysPACS1
Orthology - Evolution
OrthoDB55690
GeneTree (enSembl)ENSG00000175115
Phylogenetic Trees/Animal Genes : TreeFamPACS1
Homologs : HomoloGenePACS1
Homology/Alignments : Family Browser (UCSC)PACS1
Gene fusions - Rearrangements
Fusion : MitelmanDPP3::PACS1 [11q13.2/11q13.1]  
Fusion : MitelmanKDM2A::PACS1 [11q13.2/11q13.1]  
Fusion : MitelmanKIAA0368::PACS1 [9q31.3/11q13.1]  
Fusion : MitelmanPACS1::ZDHHC24 [11q13.1/11q13.2]  
Fusion : MitelmanPLEKHB1::PACS1 [11q13.4/11q13.1]  
Fusion : MitelmanSLC22A25::PACS1 [11q12.3/11q13.1]  
Fusion : MitelmanSYT7::PACS1 [11q12.2/11q13.1]  
Fusion Cancer (Beijing)PTEN [10q23.31]  -  PACS1 [11q13.1]  [FUSC004337]  [FUSC004337]  [FUSC004337]
Fusion : QuiverPACS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPACS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PACS1
dbVarPACS1
ClinVarPACS1
MonarchPACS1
1000_GenomesPACS1 
Exome Variant ServerPACS1
GNOMAD BrowserENSG00000175115
Varsome BrowserPACS1
ACMGPACS1 variants
VarityQ6VY07
Genomic Variants (DGV)PACS1 [DGVbeta]
DECIPHERPACS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPACS1 
Mutations
ICGC Data PortalPACS1 
TCGA Data PortalPACS1 
Broad Tumor PortalPACS1
OASIS PortalPACS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPACS1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPACS1
Mutations and Diseases : HGMDPACS1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPACS1
DgiDB (Drug Gene Interaction Database)PACS1
DoCM (Curated mutations)PACS1
CIViC (Clinical Interpretations of Variants in Cancer)PACS1
Cancer3DPACS1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607492    615009   
Orphanet21910   
DisGeNETPACS1
MedgenPACS1
Genetic Testing Registry PACS1
NextProtQ6VY07 [Medical]
GENETestsPACS1
Target ValidationPACS1
Huge Navigator PACS1 [HugePedia]
ClinGenPACS1
Clinical trials, drugs, therapy
MyCancerGenomePACS1
Protein Interactions : CTDPACS1
Pharm GKB GenePA134989529
PharosQ6VY07
Clinical trialPACS1
Miscellaneous
canSAR (ICR)PACS1
HarmonizomePACS1
ARCHS4PACS1
DataMed IndexPACS1
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPACS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:26:14 CET 2022

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