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PACSIN3 (protein kinase C and casein kinase substrate in neurons 3)

Identity

Alias (NCBI)SDPIII
HGNC (Hugo) PACSIN3
HGNC Alias symbSDPIII
HGNC Alias namesyndapin III
LocusID (NCBI) 29763
Atlas_Id 54523
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 47177522 and ends at 47186434 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NAV2 (11p15.1) / PACSIN3 (11p11.2)PACSIN3 (11p11.2) / CTSD (11p15.5)PHF21A (11p11.2) / PACSIN3 (11p11.2)
NAV2 11p15.1 / PACSIN3 11p11.2PHF21A 11p11.2 / PACSIN3 11p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PACSIN3   8572
Cards
Entrez_Gene (NCBI)PACSIN3    protein kinase C and casein kinase substrate in neurons 3
AliasesSDPIII
GeneCards (Weizmann)PACSIN3
Ensembl hg19 (Hinxton)ENSG00000165912 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165912 [Gene_View]  ENSG00000165912 [Sequence]  chr11:47177522-47186434 [Contig_View]  PACSIN3 [Vega]
ICGC DataPortalENSG00000165912
TCGA cBioPortalPACSIN3
AceView (NCBI)PACSIN3
Genatlas (Paris)PACSIN3
SOURCE (Princeton)PACSIN3
Genetics Home Reference (NIH)PACSIN3
Genomic and cartography
GoldenPath hg38 (UCSC)PACSIN3  -     chr11:47177522-47186434 -  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PACSIN3  -     11p11.2   [Description]    (hg19-Feb_2009)
GoldenPathPACSIN3 - 11p11.2 [CytoView hg19]  PACSIN3 - 11p11.2 [CytoView hg38]
ImmunoBaseENSG00000165912
Genome Data Viewer NCBIPACSIN3 [Mapview hg19]  
OMIM606513   
Gene and transcription
Genbank (Entrez)AF130979 AF149825 AF242530 AK000577 AK300658
RefSeq transcript (Entrez)NM_001184974 NM_001184975 NM_016223
Consensus coding sequences : CCDS (NCBI)PACSIN3
Gene ExpressionPACSIN3 [ NCBI-GEO ]   PACSIN3 [ EBI - ARRAY_EXPRESS ]   PACSIN3 [ SEEK ]   PACSIN3 [ MEM ]
Gene Expression Viewer (FireBrowse)PACSIN3 [ Firebrowse - Broad ]
GenevisibleExpression of PACSIN3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29763
GTEX Portal (Tissue expression)PACSIN3
Human Protein AtlasENSG00000165912-PACSIN3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKS6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKS6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKS6
PhosPhoSitePlusQ9UKS6
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)    SH3 (PS50002)   
Domains : Interpro (EBI)AH/BAR_dom_sf    F_BAR    FCH_dom    PACSIN3    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)FCH (PF00611)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00611    pfam14604   
Domain families : Smart (EMBL)FCH (SM00055)  SH3 (SM00326)  
Conserved Domain (NCBI)PACSIN3
SuperfamilyQ9UKS6
AlphaFold pdb e-kbQ9UKS6   
Human Protein Atlas [tissue]ENSG00000165912-PACSIN3 [tissue]
HPRD05937
Protein Interaction databases
DIP (DOE-UCLA)Q9UKS6
IntAct (EBI)Q9UKS6
BioGRIDPACSIN3
STRING (EMBL)PACSIN3
ZODIACPACSIN3
Ontologies - Pathways
QuickGOQ9UKS6
Ontology : AmiGOprotein binding  phospholipid binding  cytoplasm  cytoplasm  endosome  cytosol  plasma membrane  plasma membrane  endocytosis  cytoskeleton organization  cytoskeletal protein binding  lipid binding  calcium channel inhibitor activity  regulation of endocytosis  identical protein binding  negative regulation of endocytosis  positive regulation of membrane protein ectodomain proteolysis  negative regulation of calcium ion transport  extracellular exosome  plasma membrane tubulation  plasma membrane tubulation  
Ontology : EGO-EBIprotein binding  phospholipid binding  cytoplasm  cytoplasm  endosome  cytosol  plasma membrane  plasma membrane  endocytosis  cytoskeleton organization  cytoskeletal protein binding  lipid binding  calcium channel inhibitor activity  regulation of endocytosis  identical protein binding  negative regulation of endocytosis  positive regulation of membrane protein ectodomain proteolysis  negative regulation of calcium ion transport  extracellular exosome  plasma membrane tubulation  plasma membrane tubulation  
NDEx NetworkPACSIN3
Atlas of Cancer Signalling NetworkPACSIN3
Wikipedia pathwaysPACSIN3
Orthology - Evolution
OrthoDB29763
GeneTree (enSembl)ENSG00000165912
Phylogenetic Trees/Animal Genes : TreeFamPACSIN3
Homologs : HomoloGenePACSIN3
Homology/Alignments : Family Browser (UCSC)PACSIN3
Gene fusions - Rearrangements
Fusion : MitelmanNAV2/PACSIN3 [11p15.1/11p11.2]  
Fusion : MitelmanPACSIN3/CTSD [11p11.2/11p15.5]  
Fusion : MitelmanPHF21A/PACSIN3 [11p11.2/11p11.2]  
Fusion : QuiverPACSIN3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPACSIN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PACSIN3
dbVarPACSIN3
ClinVarPACSIN3
MonarchPACSIN3
1000_GenomesPACSIN3 
Exome Variant ServerPACSIN3
GNOMAD BrowserENSG00000165912
Varsome BrowserPACSIN3
ACMGPACSIN3 variants
VarityQ9UKS6
Genomic Variants (DGV)PACSIN3 [DGVbeta]
DECIPHERPACSIN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPACSIN3 
Mutations
ICGC Data PortalPACSIN3 
TCGA Data PortalPACSIN3 
Broad Tumor PortalPACSIN3
OASIS PortalPACSIN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPACSIN3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPACSIN3
Mutations and Diseases : HGMDPACSIN3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPACSIN3
DgiDB (Drug Gene Interaction Database)PACSIN3
DoCM (Curated mutations)PACSIN3
CIViC (Clinical Interpretations of Variants in Cancer)PACSIN3
Cancer3DPACSIN3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606513   
Orphanet
DisGeNETPACSIN3
MedgenPACSIN3
Genetic Testing Registry PACSIN3
NextProtQ9UKS6 [Medical]
GENETestsPACSIN3
Target ValidationPACSIN3
Huge Navigator PACSIN3 [HugePedia]
ClinGenPACSIN3
Clinical trials, drugs, therapy
MyCancerGenomePACSIN3
Protein Interactions : CTDPACSIN3
Pharm GKB GenePA32898
PharosQ9UKS6
Clinical trialPACSIN3
Miscellaneous
canSAR (ICR)PACSIN3
HarmonizomePACSIN3
DataMed IndexPACSIN3
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPACSIN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:24:09 CEST 2021

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