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PACSIN3 (protein kinase C and casein kinase substrate in neurons 3)

Identity

Alias_symbol (synonym)SDPIII
Other alias
HGNC (Hugo) PACSIN3
LocusID (NCBI) 29763
Atlas_Id 54523
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 47177522 and ends at 47186459 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NAV2 (11p15.1) / PACSIN3 (11p11.2)PACSIN3 (11p11.2) / CTSD (11p15.5)PHF21A (11p11.2) / PACSIN3 (11p11.2)
NAV2 11p15.1 / PACSIN3 11p11.2PHF21A 11p11.2 / PACSIN3 11p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PACSIN3   8572
Cards
Entrez_Gene (NCBI)PACSIN3  29763  protein kinase C and casein kinase substrate in neurons 3
AliasesSDPIII
GeneCards (Weizmann)PACSIN3
Ensembl hg19 (Hinxton)ENSG00000165912 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165912 [Gene_View]  chr11:47177522-47186459 [Contig_View]  PACSIN3 [Vega]
ICGC DataPortalENSG00000165912
TCGA cBioPortalPACSIN3
AceView (NCBI)PACSIN3
Genatlas (Paris)PACSIN3
WikiGenes29763
SOURCE (Princeton)PACSIN3
Genetics Home Reference (NIH)PACSIN3
Genomic and cartography
GoldenPath hg38 (UCSC)PACSIN3  -     chr11:47177522-47186459 -  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PACSIN3  -     11p11.2   [Description]    (hg19-Feb_2009)
EnsemblPACSIN3 - 11p11.2 [CytoView hg19]  PACSIN3 - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBIPACSIN3 [Mapview hg19]  PACSIN3 [Mapview hg38]
OMIM606513   
Gene and transcription
Genbank (Entrez)AB528520 AF130979 AF149825 AF242530 AK000577
RefSeq transcript (Entrez)NM_001184974 NM_001184975 NM_016223
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PACSIN3
Cluster EST : UnigeneHs.334639 [ NCBI ]
CGAP (NCI)Hs.334639
Alternative Splicing GalleryENSG00000165912
Gene ExpressionPACSIN3 [ NCBI-GEO ]   PACSIN3 [ EBI - ARRAY_EXPRESS ]   PACSIN3 [ SEEK ]   PACSIN3 [ MEM ]
Gene Expression Viewer (FireBrowse)PACSIN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29763
GTEX Portal (Tissue expression)PACSIN3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKS6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKS6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKS6
Splice isoforms : SwissVarQ9UKS6
PhosPhoSitePlusQ9UKS6
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)    SH3 (PS50002)   
Domains : Interpro (EBI)F_BAR    FCH_dom    PACSIN3    SH3_domain   
Domain families : Pfam (Sanger)FCH (PF00611)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00611    pfam14604   
Domain families : Smart (EMBL)FCH (SM00055)  SH3 (SM00326)  
Conserved Domain (NCBI)PACSIN3
DMDM Disease mutations29763
Blocks (Seattle)PACSIN3
SuperfamilyQ9UKS6
Human Protein AtlasENSG00000165912
Peptide AtlasQ9UKS6
HPRD05937
IPIIPI00980056   IPI00329572   IPI00909672   IPI00984822   IPI00984189   IPI00985274   IPI00983668   IPI00981239   IPI00980589   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKS6
IntAct (EBI)Q9UKS6
FunCoupENSG00000165912
BioGRIDPACSIN3
STRING (EMBL)PACSIN3
ZODIACPACSIN3
Ontologies - Pathways
QuickGOQ9UKS6
Ontology : AmiGOprotein binding  cytoplasm  endosome  cytosol  plasma membrane  endocytosis  cytoskeletal protein binding  lipid binding  calcium channel inhibitor activity  regulation of endocytosis  negative regulation of endocytosis  positive regulation of membrane protein ectodomain proteolysis  negative regulation of calcium ion transport  regulation of molecular function  extracellular exosome  plasma membrane tubulation  
Ontology : EGO-EBIprotein binding  cytoplasm  endosome  cytosol  plasma membrane  endocytosis  cytoskeletal protein binding  lipid binding  calcium channel inhibitor activity  regulation of endocytosis  negative regulation of endocytosis  positive regulation of membrane protein ectodomain proteolysis  negative regulation of calcium ion transport  regulation of molecular function  extracellular exosome  plasma membrane tubulation  
NDEx NetworkPACSIN3
Atlas of Cancer Signalling NetworkPACSIN3
Wikipedia pathwaysPACSIN3
Orthology - Evolution
OrthoDB29763
GeneTree (enSembl)ENSG00000165912
Phylogenetic Trees/Animal Genes : TreeFamPACSIN3
HOVERGENQ9UKS6
HOGENOMQ9UKS6
Homologs : HomoloGenePACSIN3
Homology/Alignments : Family Browser (UCSC)PACSIN3
Gene fusions - Rearrangements
Fusion : MitelmanNAV2/PACSIN3 [11p15.1/11p11.2]  [t(11;11)(p11;p15)]  
Fusion : MitelmanPACSIN3/CTSD [11p11.2/11p15.5]  [t(11;11)(p11;p15)]  
Fusion : MitelmanPHF21A/PACSIN3 [11p11.2/11p11.2]  [t(11;11)(p11;p11)]  
Fusion: TCGANAV2 11p15.1 PACSIN3 11p11.2 BRCA
Fusion: TCGAPHF21A 11p11.2 PACSIN3 11p11.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPACSIN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PACSIN3
dbVarPACSIN3
ClinVarPACSIN3
1000_GenomesPACSIN3 
Exome Variant ServerPACSIN3
ExAC (Exome Aggregation Consortium)PACSIN3 (select the gene name)
Genetic variants : HAPMAP29763
Genomic Variants (DGV)PACSIN3 [DGVbeta]
DECIPHERPACSIN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPACSIN3 
Mutations
ICGC Data PortalPACSIN3 
TCGA Data PortalPACSIN3 
Broad Tumor PortalPACSIN3
OASIS PortalPACSIN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPACSIN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPACSIN3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PACSIN3
DgiDB (Drug Gene Interaction Database)PACSIN3
DoCM (Curated mutations)PACSIN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PACSIN3 (select a term)
intoGenPACSIN3
Cancer3DPACSIN3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606513   
Orphanet
MedgenPACSIN3
Genetic Testing Registry PACSIN3
NextProtQ9UKS6 [Medical]
TSGene29763
GENETestsPACSIN3
Target ValidationPACSIN3
Huge Navigator PACSIN3 [HugePedia]
snp3D : Map Gene to Disease29763
BioCentury BCIQPACSIN3
ClinGenPACSIN3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29763
Chemical/Pharm GKB GenePA32898
Clinical trialPACSIN3
Miscellaneous
canSAR (ICR)PACSIN3 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePACSIN3
EVEXPACSIN3
GoPubMedPACSIN3
iHOPPACSIN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:23:36 CEST 2017

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