PACSIN3 (protein kinase C and casein kinase substrate in neurons 3)

2014-08-01  

Identity

HGNC
PACSIN3
LOCATION
11p11.2
LOCUSID
29763
ALIAS
SDPIII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29763
MIM: 606513
HGNC: 8572
Ensembl: ENSG00000165912

Variants:

dbSNP: 29763
ClinVar: 29763
TCGA: ENSG00000165912
COSMIC: PACSIN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165912ENST00000298838Q9UKS6
ENSG00000165912ENST00000524509E9PJ33
ENSG00000165912ENST00000525725E9PJ75
ENSG00000165912ENST00000528201E9PQ12
ENSG00000165912ENST00000528462A0A0C4DGG1
ENSG00000165912ENST00000530405E9PJ33
ENSG00000165912ENST00000530513E9PIZ6
ENSG00000165912ENST00000531226E9PNM9
ENSG00000165912ENST00000532457E9PIY1
ENSG00000165912ENST00000533686H0YDM6
ENSG00000165912ENST00000539589Q9UKS6

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
181741772008Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3.33
129529822003PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor.23
225733312012Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules.9
245002822014Syndapin 3 modulates fusion pore expansion in mouse neuroendocrine chromaffin cells.3

Citation

Dessen P

PACSIN3 (protein kinase C and casein kinase substrate in neurons 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54523/pacsin3