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PADI2 (peptidyl arginine deiminase 2)

Identity

Alias_namespeptidyl arginine deiminase
Alias_symbol (synonym)KIAA0994
PDI2
Other aliasPAD-H19
PAD2
HGNC (Hugo) PADI2
LocusID (NCBI) 11240
Atlas_Id 41631
Location 1p36.13  [Link to chromosome band 1p36]
Location_base_pair Starts at 17066761 and ends at 17119453 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PADI2   18341
Cards
Entrez_Gene (NCBI)PADI2  11240  peptidyl arginine deiminase 2
AliasesPAD-H19; PAD2; PDI2
GeneCards (Weizmann)PADI2
Ensembl hg19 (Hinxton)ENSG00000117115 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117115 [Gene_View]  chr1:17066761-17119453 [Contig_View]  PADI2 [Vega]
ICGC DataPortalENSG00000117115
TCGA cBioPortalPADI2
AceView (NCBI)PADI2
Genatlas (Paris)PADI2
WikiGenes11240
SOURCE (Princeton)PADI2
Genetics Home Reference (NIH)PADI2
Genomic and cartography
GoldenPath hg38 (UCSC)PADI2  -     chr1:17066761-17119453 -  1p36.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PADI2  -     1p36.13   [Description]    (hg19-Feb_2009)
EnsemblPADI2 - 1p36.13 [CytoView hg19]  PADI2 - 1p36.13 [CytoView hg38]
Mapping of homologs : NCBIPADI2 [Mapview hg19]  PADI2 [Mapview hg38]
OMIM607935   
Gene and transcription
Genbank (Entrez)AB023211 AB030176 AK123164 AK127006 AK295783
RefSeq transcript (Entrez)NM_007365
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PADI2
Cluster EST : UnigeneHs.33455 [ NCBI ]
CGAP (NCI)Hs.33455
Alternative Splicing GalleryENSG00000117115
Gene ExpressionPADI2 [ NCBI-GEO ]   PADI2 [ EBI - ARRAY_EXPRESS ]   PADI2 [ SEEK ]   PADI2 [ MEM ]
Gene Expression Viewer (FireBrowse)PADI2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11240
GTEX Portal (Tissue expression)PADI2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2J8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2J8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2J8
Splice isoforms : SwissVarQ9Y2J8
Catalytic activity : Enzyme3.5.3.15 [ Enzyme-Expasy ]   3.5.3.153.5.3.15 [ IntEnz-EBI ]   3.5.3.15 [ BRENDA ]   3.5.3.15 [ KEGG ]   
PhosPhoSitePlusQ9Y2J8
Domains : Interpro (EBI)Cupredoxin    PAD    PAD_C    PAD_N    Prot_Arg_deaminase_cen_dom   
Domain families : Pfam (Sanger)PAD (PF03068)    PAD_M (PF08527)    PAD_N (PF08526)   
Domain families : Pfam (NCBI)pfam03068    pfam08527    pfam08526   
Conserved Domain (NCBI)PADI2
DMDM Disease mutations11240
Blocks (Seattle)PADI2
PDB (SRS)4N20    4N22    4N24    4N25    4N26    4N28    4N2A    4N2B    4N2C    4N2D    4N2E    4N2F    4N2G    4N2H    4N2I    4N2K    4N2L    4N2M    4N2N   
PDB (PDBSum)4N20    4N22    4N24    4N25    4N26    4N28    4N2A    4N2B    4N2C    4N2D    4N2E    4N2F    4N2G    4N2H    4N2I    4N2K    4N2L    4N2M    4N2N   
PDB (IMB)4N20    4N22    4N24    4N25    4N26    4N28    4N2A    4N2B    4N2C    4N2D    4N2E    4N2F    4N2G    4N2H    4N2I    4N2K    4N2L    4N2M    4N2N   
PDB (RSDB)4N20    4N22    4N24    4N25    4N26    4N28    4N2A    4N2B    4N2C    4N2D    4N2E    4N2F    4N2G    4N2H    4N2I    4N2K    4N2L    4N2M    4N2N   
Structural Biology KnowledgeBase4N20    4N22    4N24    4N25    4N26    4N28    4N2A    4N2B    4N2C    4N2D    4N2E    4N2F    4N2G    4N2H    4N2I    4N2K    4N2L    4N2M    4N2N   
SCOP (Structural Classification of Proteins)4N20    4N22    4N24    4N25    4N26    4N28    4N2A    4N2B    4N2C    4N2D    4N2E    4N2F    4N2G    4N2H    4N2I    4N2K    4N2L    4N2M    4N2N   
CATH (Classification of proteins structures)4N20    4N22    4N24    4N25    4N26    4N28    4N2A    4N2B    4N2C    4N2D    4N2E    4N2F    4N2G    4N2H    4N2I    4N2K    4N2L    4N2M    4N2N   
SuperfamilyQ9Y2J8
Human Protein AtlasENSG00000117115
Peptide AtlasQ9Y2J8
HPRD06396
IPIIPI00294187   IPI00908559   IPI00446756   IPI00645522   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2J8
IntAct (EBI)Q9Y2J8
FunCoupENSG00000117115
BioGRIDPADI2
STRING (EMBL)PADI2
ZODIACPADI2
Ontologies - Pathways
QuickGOQ9Y2J8
Ontology : AmiGOprotein-arginine deiminase activity  calcium ion binding  extracellular region  nucleus  cytoplasm  cytosol  chromatin organization  regulation of chromatin disassembly  protein citrullination  substantia nigra development  estrogen receptor binding  intracellular estrogen receptor signaling pathway  transcriptionally active chromatin  azurophil granule lumen  histone H3-R26 citrullination  neutrophil degranulation  chromatin-mediated maintenance of transcription  extracellular exosome  negative regulation of chemokine-mediated signaling pathway  negative regulation of lymphocyte chemotaxis  
Ontology : EGO-EBIprotein-arginine deiminase activity  calcium ion binding  extracellular region  nucleus  cytoplasm  cytosol  chromatin organization  regulation of chromatin disassembly  protein citrullination  substantia nigra development  estrogen receptor binding  intracellular estrogen receptor signaling pathway  transcriptionally active chromatin  azurophil granule lumen  histone H3-R26 citrullination  neutrophil degranulation  chromatin-mediated maintenance of transcription  extracellular exosome  negative regulation of chemokine-mediated signaling pathway  negative regulation of lymphocyte chemotaxis  
NDEx NetworkPADI2
Atlas of Cancer Signalling NetworkPADI2
Wikipedia pathwaysPADI2
Orthology - Evolution
OrthoDB11240
GeneTree (enSembl)ENSG00000117115
Phylogenetic Trees/Animal Genes : TreeFamPADI2
HOVERGENQ9Y2J8
HOGENOMQ9Y2J8
Homologs : HomoloGenePADI2
Homology/Alignments : Family Browser (UCSC)PADI2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPADI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PADI2
dbVarPADI2
ClinVarPADI2
1000_GenomesPADI2 
Exome Variant ServerPADI2
ExAC (Exome Aggregation Consortium)PADI2 (select the gene name)
Genetic variants : HAPMAP11240
Genomic Variants (DGV)PADI2 [DGVbeta]
DECIPHERPADI2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPADI2 
Mutations
ICGC Data PortalPADI2 
TCGA Data PortalPADI2 
Broad Tumor PortalPADI2
OASIS PortalPADI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPADI2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPADI2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PADI2
DgiDB (Drug Gene Interaction Database)PADI2
DoCM (Curated mutations)PADI2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PADI2 (select a term)
intoGenPADI2
Cancer3DPADI2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607935   
Orphanet
MedgenPADI2
Genetic Testing Registry PADI2
NextProtQ9Y2J8 [Medical]
TSGene11240
GENETestsPADI2
Huge Navigator PADI2 [HugePedia]
snp3D : Map Gene to Disease11240
BioCentury BCIQPADI2
ClinGenPADI2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11240
Chemical/Pharm GKB GenePA32900
Clinical trialPADI2
Miscellaneous
canSAR (ICR)PADI2 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePADI2
EVEXPADI2
GoPubMedPADI2
iHOPPADI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:30:05 CEST 2017

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