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PADI4 (peptidyl arginine deiminase 4)

Identity

Alias_namesPADI5
peptidyl arginine deiminase, type V
peptidyl arginine deiminase, type IV
Alias_symbol (synonym)PAD
PDI5
PDI4
Other aliasPAD4
HGNC (Hugo) PADI4
LocusID (NCBI) 23569
Atlas_Id 45545
Location 1p36.13  [Link to chromosome band 1p36]
Location_base_pair Starts at 17308195 and ends at 17364000 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGEF10L (1p36.13) / PADI4 (1p36.13)PADI4 (1p36.13) / PADI4 (1p36.13)RCC2 (1p36.13) / PADI4 (1p36.13)
ARHGEF10L 1p36.13 / PADI4 1p36.13RCC2 1p36.13 / PADI4 1p36.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PADI4   18368
Cards
Entrez_Gene (NCBI)PADI4  23569  peptidyl arginine deiminase 4
AliasesPAD; PAD4; PADI5; PDI4; 
PDI5
GeneCards (Weizmann)PADI4
Ensembl hg19 (Hinxton)ENSG00000159339 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159339 [Gene_View]  chr1:17308195-17364000 [Contig_View]  PADI4 [Vega]
ICGC DataPortalENSG00000159339
TCGA cBioPortalPADI4
AceView (NCBI)PADI4
Genatlas (Paris)PADI4
WikiGenes23569
SOURCE (Princeton)PADI4
Genetics Home Reference (NIH)PADI4
Genomic and cartography
GoldenPath hg38 (UCSC)PADI4  -     chr1:17308195-17364000 +  1p36.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PADI4  -     1p36.13   [Description]    (hf19-Ĉeb[2009)
EnsemblPADI4 - 1p36.13 [CytoView hg19]  PADI4 - 1p36.13 [CytoView hg38]
Mapping of homologs : NCBIPADI4 [Mapview hg19]  PADI4 [Mapview hg38]
OMIM180300   605347   
Gene and transcription
Genbank (Entrez)AB017919 AF229067 AK290507 AK309637 AK314839
RefSeq transcript (Entrez)NM_012387
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PADI4
Cluster EST : UnigeneHs.522969 [ NCBI ]
CGAP (NCI)Hs.522969
Alternative Splicing GalleryENSG00000159339
Gene ExpressionPADI4 [ NCBI-GEO ]   PADI4 [ EBI - ARRAY_EXPRESS ]   PADI4 [ SEEK ]   PADI4 [ MEM ]
Gene Expression Viewer (FireBrowse)PADI4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23569
GTEX Portal (Tissue expression)PADI4
Human Protein AtlasENSG00000159339-PADI4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UM07   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UM07  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UM07
Splice isoforms : SwissVarQ9UM07
Catalytic activity : Enzyme3.5.3.15 [ Enzyme-Expasy ]   3.5.3.153.5.3.15 [ IntEnz-EBI ]   3.5.3.15 [ BRENDA ]   3.5.3.15 [ KEGG ]   
PhosPhoSitePlusQ9UM07
Domains : Interpro (EBI)Cupredoxin    PAD    PAD_C    PAD_N    Prot_Arg_deaminase_cen_dom   
Domain families : Pfam (Sanger)PAD (PF03068)    PAD_M (PF08527)    PAD_N (PF08526)   
Domain families : Pfam (NCBI)pfam03068    pfam08527    pfam08526   
Conserved Domain (NCBI)PADI4
DMDM Disease mutations23569
Blocks (Seattle)PADI4
PDB (SRS)1WD8    1WD9    1WDA    2DEW    2DEX    2DEY    2DW5    3APM    3APN    3B1T    3B1U    4DKT    4X8C    4X8G   
PDB (PDBSum)1WD8    1WD9    1WDA    2DEW    2DEX    2DEY    2DW5    3APM    3APN    3B1T    3B1U    4DKT    4X8C    4X8G   
PDB (IMB)1WD8    1WD9    1WDA    2DEW    2DEX    2DEY    2DW5    3APM    3APN    3B1T    3B1U    4DKT    4X8C    4X8G   
PDB (RSDB)1WD8    1WD9    1WDA    2DEW    2DEX    2DEY    2DW5    3APM    3APN    3B1T    3B1U    4DKT    4X8C    4X8G   
Structural Biology KnowledgeBase1WD8    1WD9    1WDA    2DEW    2DEX    2DEY    2DW5    3APM    3APN    3B1T    3B1U    4DKT    4X8C    4X8G   
SCOP (Structural Classification of Proteins)1WD8    1WD9    1WDA    2DEW    2DEX    2DEY    2DW5    3APM    3APN    3B1T    3B1U    4DKT    4X8C    4X8G   
CATH (Classification of proteins structures)1WD8    1WD9    1WDA    2DEW    2DEX    2DEY    2DW5    3APM    3APN    3B1T    3B1U    4DKT    4X8C    4X8G   
SuperfamilyQ9UM07
Human Protein Atlas [tissue]ENSG00000159339-PADI4 [tissue]
Peptide AtlasQ9UM07
HPRD05635
IPIIPI00008307   IPI00385529   
Protein Interaction databases
DIP (DOE-UCLA)Q9UM07
IntAct (EBI)Q9UM07
FunCoupENSG00000159339
BioGRIDPADI4
STRING (EMBL)PADI4
ZODIACPADI4
Ontologies - Pathways
QuickGOQ9UM07
Ontology : AmiGOprotein-arginine deiminase activity  protein-arginine deiminase activity  protein-arginine deiminase activity  calcium ion binding  calcium ion binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  chromatin organization  chromatin organization  nucleosome assembly  chromatin remodeling  transcription, DNA-templated  regulation of transcription, DNA-templated  cellular protein modification process  arginine deiminase activity  protein citrullination  protein citrullination  arginine deiminase pathway  stem cell population maintenance  arginine binding  histone H3-R26 citrullination  histone citrullination  protein homodimerization activity  protein complex  innate immune response  
Ontology : EGO-EBIprotein-arginine deiminase activity  protein-arginine deiminase activity  protein-arginine deiminase activity  calcium ion binding  calcium ion binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  chromatin organization  chromatin organization  nucleosome assembly  chromatin remodeling  transcription, DNA-templated  regulation of transcription, DNA-templated  cellular protein modification process  arginine deiminase activity  protein citrullination  protein citrullination  arginine deiminase pathway  stem cell population maintenance  arginine binding  histone H3-R26 citrullination  histone citrullination  protein homodimerization activity  protein complex  innate immune response  
NDEx NetworkPADI4
Atlas of Cancer Signalling NetworkPADI4
Wikipedia pathwaysPADI4
Orthology - Evolution
OrthoDB23569
GeneTree (enSembl)ENSG00000159339
Phylogenetic Trees/Animal Genes : TreeFamPADI4
HOVERGENQ9UM07
HOGENOMQ9UM07
Homologs : HomoloGenePADI4
Homology/Alignments : Family Browser (UCSC)PADI4
Gene fusions - Rearrangements
Fusion : MitelmanARHGEF10L/PADI4 [1p36.13/1p36.13]  [t(1;1)(p36;p36)]  
Fusion : MitelmanRCC2/PADI4 [1p36.13/1p36.13]  [t(1;1)(p36;p36)]  
Fusion: TCGA_MDACCARHGEF10L 1p36.13 PADI4 1p36.13 BRCA LUAD LUSC
Fusion: TCGA_MDACCRCC2 1p36.13 PADI4 1p36.13 BRCA
Tumor Fusion PortalPADI4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPADI4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PADI4
dbVarPADI4
ClinVarPADI4
1000_GenomesPADI4 
Exome Variant ServerPADI4
ExAC (Exome Aggregation Consortium)ENSG00000159339
GNOMAD BrowserENSG00000159339
Genetic variants : HAPMAP23569
Genomic Variants (DGV)PADI4 [DGVbeta]
DECIPHERPADI4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPADI4 
Mutations
ICGC Data PortalPADI4 
TCGA Data PortalPADI4 
Broad Tumor PortalPADI4
OASIS PortalPADI4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPADI4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPADI4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PADI4
DgiDB (Drug Gene Interaction Database)PADI4
DoCM (Curated mutations)PADI4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PADI4 (select a term)
intoGenPADI4
Cancer3DPADI4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180300    605347   
Orphanet
DisGeNETPADI4
MedgenPADI4
Genetic Testing Registry PADI4
NextProtQ9UM07 [Medical]
TSGene23569
GENETestsPADI4
Target ValidationPADI4
Huge Navigator PADI4 [HugePedia]
snp3D : Map Gene to Disease23569
BioCentury BCIQPADI4
ClinGenPADI4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23569
Chemical/Pharm GKB GenePA32903
Clinical trialPADI4
Miscellaneous
canSAR (ICR)PADI4 (select the gene name)
Probes
Litterature
PubMed129 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePADI4
EVEXPADI4
GoPubMedPADI4
iHOPPADI4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:27:38 CET 2017

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