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PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1)

Identity

Alias_namesphosphoprotein associated with glycosphingolipid microdomains 1
Alias_symbol (synonym)PAG
CBP
Other alias
HGNC (Hugo) PAG1
LocusID (NCBI) 55824
Atlas_Id 50191
Location 8q21.13  [Link to chromosome band 8q21]
Location_base_pair Starts at 80967811 and ends at 81112068 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LSM14A (19q13.11) / PAG1 (8q21.13)PAG1 (8q21.13) / ARIH2 (3p21.31)PAG1 (8q21.13) / PAG1 (8q21.13)
PAG1 (8q21.13) / STYX (14q22.1)ZNF704 (8q21.13) / PAG1 (8q21.13)ZNF704 8q21.13 / PAG1 8q21.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PAG1   30043
Cards
Entrez_Gene (NCBI)PAG1  55824  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
AliasesCBP; PAG
GeneCards (Weizmann)PAG1
Ensembl hg19 (Hinxton)ENSG00000076641 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000076641 [Gene_View]  chr8:80967811-81112068 [Contig_View]  PAG1 [Vega]
ICGC DataPortalENSG00000076641
TCGA cBioPortalPAG1
AceView (NCBI)PAG1
Genatlas (Paris)PAG1
WikiGenes55824
SOURCE (Princeton)PAG1
Genetics Home Reference (NIH)PAG1
Genomic and cartography
GoldenPath hg38 (UCSC)PAG1  -     chr8:80967811-81112068 -  8q21.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PAG1  -     8q21.13   [Description]    (hg19-Feb_2009)
EnsemblPAG1 - 8q21.13 [CytoView hg19]  PAG1 - 8q21.13 [CytoView hg38]
Mapping of homologs : NCBIPAG1 [Mapview hg19]  PAG1 [Mapview hg38]
OMIM605767   
Gene and transcription
Genbank (Entrez)AA766638 AF240634 AK000680 AK095177 AK289818
RefSeq transcript (Entrez)NM_018440
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PAG1
Cluster EST : UnigeneHs.266175 [ NCBI ]
CGAP (NCI)Hs.266175
Alternative Splicing GalleryENSG00000076641
Gene ExpressionPAG1 [ NCBI-GEO ]   PAG1 [ EBI - ARRAY_EXPRESS ]   PAG1 [ SEEK ]   PAG1 [ MEM ]
Gene Expression Viewer (FireBrowse)PAG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55824
GTEX Portal (Tissue expression)PAG1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NWQ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NWQ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NWQ8
Splice isoforms : SwissVarQ9NWQ8
PhosPhoSitePlusQ9NWQ8
Domains : Interpro (EBI)PAG   
Domain families : Pfam (Sanger)PAG (PF15347)   
Domain families : Pfam (NCBI)pfam15347   
Domain structure : Prodom (Prabi Lyon)PD340439 (PD340439)   
Conserved Domain (NCBI)PAG1
DMDM Disease mutations55824
Blocks (Seattle)PAG1
SuperfamilyQ9NWQ8
Human Protein AtlasENSG00000076641
Peptide AtlasQ9NWQ8
HPRD05772
IPIIPI00020464   
Protein Interaction databases
DIP (DOE-UCLA)Q9NWQ8
IntAct (EBI)Q9NWQ8
FunCoupENSG00000076641
BioGRIDPAG1
STRING (EMBL)PAG1
ZODIACPAG1
Ontologies - Pathways
QuickGOQ9NWQ8
Ontology : AmiGOadaptive immune response  transmembrane receptor protein tyrosine kinase adaptor activity  SH3/SH2 adaptor activity  protein binding  intracellular  plasma membrane  plasma membrane  integral component of plasma membrane  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  epidermal growth factor receptor signaling pathway  positive regulation of signal transduction  intracellular signal transduction  SH2 domain binding  membrane raft  T cell receptor signaling pathway  regulation of T cell activation  negative regulation of T cell activation  
Ontology : EGO-EBIadaptive immune response  transmembrane receptor protein tyrosine kinase adaptor activity  SH3/SH2 adaptor activity  protein binding  intracellular  plasma membrane  plasma membrane  integral component of plasma membrane  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  epidermal growth factor receptor signaling pathway  positive regulation of signal transduction  intracellular signal transduction  SH2 domain binding  membrane raft  T cell receptor signaling pathway  regulation of T cell activation  negative regulation of T cell activation  
NDEx NetworkPAG1
Atlas of Cancer Signalling NetworkPAG1
Wikipedia pathwaysPAG1
Orthology - Evolution
OrthoDB55824
GeneTree (enSembl)ENSG00000076641
Phylogenetic Trees/Animal Genes : TreeFamPAG1
HOVERGENQ9NWQ8
HOGENOMQ9NWQ8
Homologs : HomoloGenePAG1
Homology/Alignments : Family Browser (UCSC)PAG1
Gene fusions - Rearrangements
Fusion : MitelmanZNF704/PAG1 [8q21.13/8q21.13]  [t(8;8)(q21;q21)]  
Fusion: TCGAZNF704 8q21.13 PAG1 8q21.13 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPAG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PAG1
dbVarPAG1
ClinVarPAG1
1000_GenomesPAG1 
Exome Variant ServerPAG1
ExAC (Exome Aggregation Consortium)PAG1 (select the gene name)
Genetic variants : HAPMAP55824
Genomic Variants (DGV)PAG1 [DGVbeta]
DECIPHERPAG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPAG1 
Mutations
ICGC Data PortalPAG1 
TCGA Data PortalPAG1 
Broad Tumor PortalPAG1
OASIS PortalPAG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPAG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPAG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PAG1
DgiDB (Drug Gene Interaction Database)PAG1
DoCM (Curated mutations)PAG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PAG1 (select a term)
intoGenPAG1
Cancer3DPAG1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605767   
Orphanet
MedgenPAG1
Genetic Testing Registry PAG1
NextProtQ9NWQ8 [Medical]
TSGene55824
GENETestsPAG1
Target ValidationPAG1
Huge Navigator PAG1 [HugePedia]
snp3D : Map Gene to Disease55824
BioCentury BCIQPAG1
ClinGenPAG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55824
Chemical/Pharm GKB GenePA142671201
Clinical trialPAG1
Miscellaneous
canSAR (ICR)PAG1 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePAG1
EVEXPAG1
GoPubMedPAG1
iHOPPAG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:09:58 CEST 2017

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