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PAK4 (p21 (RAC1) activated kinase 4)

Identity

Alias (NCBI)-
HGNC (Hugo) PAK4
HGNC Previous namep21(CDKN1A)-activated kinase 4
 p21 protein (Cdc42/Rac)-activated kinase 4
LocusID (NCBI) 10298
Atlas_Id 43393
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 39125786 and ends at 39182816 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PAK4 (19q13.2) / CATSPERG (19q13.2)PAK4 (19q13.2) / LEUTX (19q13.2)PAK4 (19q13.2) / MALL (2q13)
PAK4 (19q13.2) / MROH7 (1p32.3)PAK4 (19q13.2) / PAK4 (19q13.2)PAK4 (19q13.2) / SPINT2 (19q13.2)
PAK4 (19q13.2) / ZFP36 (19q13.2)RPS12 (6q23.2) / PAK4 (19q13.2)PAK4 19q13.2 / CATSPERG 19q13.2
PAK4 19q13.2 HEATR8PAK4 19q13.2 / SPINT2 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PAK4   16059
Cards
Entrez_Gene (NCBI)PAK4    p21 (RAC1) activated kinase 4
Aliases
GeneCards (Weizmann)PAK4
Ensembl hg19 (Hinxton)ENSG00000130669 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130669 [Gene_View]  ENSG00000130669 [Sequence]  chr19:39125786-39182816 [Contig_View]  PAK4 [Vega]
ICGC DataPortalENSG00000130669
TCGA cBioPortalPAK4
AceView (NCBI)PAK4
Genatlas (Paris)PAK4
SOURCE (Princeton)PAK4
Genetics Home Reference (NIH)PAK4
Genomic and cartography
GoldenPath hg38 (UCSC)PAK4  -     chr19:39125786-39182816 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PAK4  -     19q13.2   [Description]    (hg19-Feb_2009)
GoldenPathPAK4 - 19q13.2 [CytoView hg19]  PAK4 - 19q13.2 [CytoView hg38]
ImmunoBaseENSG00000130669
Genome Data Viewer NCBIPAK4 [Mapview hg19]  
OMIM605451   
Gene and transcription
Genbank (Entrez)AB032968 AF005046 AJ011855 AK074728 AK291839
RefSeq transcript (Entrez)NM_001014831 NM_001014832 NM_001014833 NM_001014834 NM_001014835 NM_001394501 NM_005884
Consensus coding sequences : CCDS (NCBI)PAK4
Gene ExpressionPAK4 [ NCBI-GEO ]   PAK4 [ EBI - ARRAY_EXPRESS ]   PAK4 [ SEEK ]   PAK4 [ MEM ]
Gene Expression Viewer (FireBrowse)PAK4 [ Firebrowse - Broad ]
GenevisibleExpression of PAK4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10298
GTEX Portal (Tissue expression)PAK4
Human Protein AtlasENSG00000130669-PAK4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO96013   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO96013  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO96013
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO96013
Domaine pattern : Prosite (Expaxy)CRIB (PS50108)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)CRIB_dom    CRIB_dom_sf    Kinase-like_dom_sf    PAK_BD    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)PBD (PF00786)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00786    pfam00069   
Domain families : Smart (EMBL)PBD (SM00285)  
Conserved Domain (NCBI)PAK4
PDB (RSDB)2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B    5UPK    5UPL    5VED    5VEE    5VEF    5XVA    5XVF    5XVG    5ZJW    6WLX    6WLY   
PDB Europe2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B    5UPK    5UPL    5VED    5VEE    5VEF    5XVA    5XVF    5XVG    5ZJW    6WLX    6WLY   
PDB (PDBSum)2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B    5UPK    5UPL    5VED    5VEE    5VEF    5XVA    5XVF    5XVG    5ZJW    6WLX    6WLY   
PDB (IMB)2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B    5UPK    5UPL    5VED    5VEE    5VEF    5XVA    5XVF    5XVG    5ZJW    6WLX    6WLY   
Structural Biology KnowledgeBase2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B    5UPK    5UPL    5VED    5VEE    5VEF    5XVA    5XVF    5XVG    5ZJW    6WLX    6WLY   
SCOP (Structural Classification of Proteins)2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B    5UPK    5UPL    5VED    5VEE    5VEF    5XVA    5XVF    5XVG    5ZJW    6WLX    6WLY   
CATH (Classification of proteins structures)2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B    5UPK    5UPL    5VED    5VEE    5VEF    5XVA    5XVF    5XVG    5ZJW    6WLX    6WLY   
SuperfamilyO96013
AlphaFold pdb e-kbO96013   
Human Protein Atlas [tissue]ENSG00000130669-PAK4 [tissue]
HPRD05675
Protein Interaction databases
DIP (DOE-UCLA)O96013
IntAct (EBI)O96013
BioGRIDPAK4
STRING (EMBL)PAK4
ZODIACPAK4
Ontologies - Pathways
QuickGOO96013
Ontology : AmiGOregulation of cell growth  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  adherens junction  focal adhesion  protein phosphorylation  apoptotic process  cytoskeleton organization  cell cycle  signal transduction  cell migration  activation of protein kinase activity  intracellular signal transduction  regulation of MAPK cascade  positive regulation of angiogenesis  cell-cell adhesion  cadherin binding involved in cell-cell adhesion  protein serine kinase activity  protein threonine kinase activity  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIregulation of cell growth  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  adherens junction  focal adhesion  protein phosphorylation  apoptotic process  cytoskeleton organization  cell cycle  signal transduction  cell migration  activation of protein kinase activity  intracellular signal transduction  regulation of MAPK cascade  positive regulation of angiogenesis  cell-cell adhesion  cadherin binding involved in cell-cell adhesion  protein serine kinase activity  protein threonine kinase activity  negative regulation of endothelial cell apoptotic process  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]   
Pathways : KEGGErbB signaling pathway    Ras signaling pathway    Axon guidance    Focal adhesion    T cell receptor signaling pathway    Regulation of actin cytoskeleton    MicroRNAs in cancer    Renal cell carcinoma   
NDEx NetworkPAK4
Atlas of Cancer Signalling NetworkPAK4
Wikipedia pathwaysPAK4
Orthology - Evolution
OrthoDB10298
GeneTree (enSembl)ENSG00000130669
Phylogenetic Trees/Animal Genes : TreeFamPAK4
Homologs : HomoloGenePAK4
Homology/Alignments : Family Browser (UCSC)PAK4
Gene fusions - Rearrangements
Fusion : MitelmanPAK4/CATSPERG [19q13.2/19q13.2]  
Fusion : MitelmanPAK4/MROH7 [19q13.2/1p32.3]  
Fusion : MitelmanPAK4/SPINT2 [19q13.2/19q13.2]  
Fusion : QuiverPAK4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPAK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PAK4
dbVarPAK4
ClinVarPAK4
MonarchPAK4
1000_GenomesPAK4 
Exome Variant ServerPAK4
GNOMAD BrowserENSG00000130669
Varsome BrowserPAK4
ACMGPAK4 variants
VarityO96013
Genomic Variants (DGV)PAK4 [DGVbeta]
DECIPHERPAK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPAK4 
Mutations
ICGC Data PortalPAK4 
TCGA Data PortalPAK4 
Broad Tumor PortalPAK4
OASIS PortalPAK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPAK4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPAK4
Mutations and Diseases : HGMDPAK4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPAK4
DgiDB (Drug Gene Interaction Database)PAK4
DoCM (Curated mutations)PAK4
CIViC (Clinical Interpretations of Variants in Cancer)PAK4
Cancer3DPAK4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605451   
Orphanet
DisGeNETPAK4
MedgenPAK4
Genetic Testing Registry PAK4
NextProtO96013 [Medical]
GENETestsPAK4
Target ValidationPAK4
Huge Navigator PAK4 [HugePedia]
ClinGenPAK4
Clinical trials, drugs, therapy
MyCancerGenomePAK4
Protein Interactions : CTDPAK4
Pharm GKB GenePA32920
PharosO96013
Clinical trialPAK4
Miscellaneous
canSAR (ICR)PAK4
HarmonizomePAK4
DataMed IndexPAK4
Probes
Litterature
PubMed165 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPAK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:24:13 CEST 2021

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