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PAK4 (p21 (RAC1) activated kinase 4)

Identity

Alias_namesp21(CDKN1A)-activated kinase 4
p21 protein (Cdc42/Rac)-activated kinase 4
Other alias-
HGNC (Hugo) PAK4
LocusID (NCBI) 10298
Atlas_Id 43393
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 39125780 and ends at 39179406 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PAK4 (19q13.2) / CATSPERG (19q13.2)PAK4 (19q13.2) / LEUTX (19q13.2)PAK4 (19q13.2) / MALL (2q13)
PAK4 (19q13.2) / MROH7 (1p32.3)PAK4 (19q13.2) / PAK4 (19q13.2)PAK4 (19q13.2) / SPINT2 (19q13.2)
PAK4 (19q13.2) / ZFP36 (19q13.2)RPS12 (6q23.2) / PAK4 (19q13.2)PAK4 19q13.2 / CATSPERG 19q13.2
PAK4 19q13.2 HEATR8PAK4 19q13.2 / SPINT2 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PAK4   16059
Cards
Entrez_Gene (NCBI)PAK4  10298  p21 (RAC1) activated kinase 4
Aliases
GeneCards (Weizmann)PAK4
Ensembl hg19 (Hinxton)ENSG00000130669 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130669 [Gene_View]  chr19:39125780-39179406 [Contig_View]  PAK4 [Vega]
ICGC DataPortalENSG00000130669
TCGA cBioPortalPAK4
AceView (NCBI)PAK4
Genatlas (Paris)PAK4
WikiGenes10298
SOURCE (Princeton)PAK4
Genetics Home Reference (NIH)PAK4
Genomic and cartography
GoldenPath hg38 (UCSC)PAK4  -     chr19:39125780-39179406 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PAK4  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblPAK4 - 19q13.2 [CytoView hg19]  PAK4 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIPAK4 [Mapview hg19]  PAK4 [Mapview hg38]
OMIM605451   
Gene and transcription
Genbank (Entrez)AB032968 AF005046 AJ011855 AK074728 AK291839
RefSeq transcript (Entrez)NM_001014831 NM_001014832 NM_001014833 NM_001014834 NM_001014835 NM_005884
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PAK4
Cluster EST : UnigeneHs.20447 [ NCBI ]
CGAP (NCI)Hs.20447
Alternative Splicing GalleryENSG00000130669
Gene ExpressionPAK4 [ NCBI-GEO ]   PAK4 [ EBI - ARRAY_EXPRESS ]   PAK4 [ SEEK ]   PAK4 [ MEM ]
Gene Expression Viewer (FireBrowse)PAK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10298
GTEX Portal (Tissue expression)PAK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO96013   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO96013  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO96013
Splice isoforms : SwissVarO96013
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusO96013
Domaine pattern : Prosite (Expaxy)CRIB (PS50108)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)CRIB_dom    Kinase-like_dom    PAK_BD    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)PBD (PF00786)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00786    pfam00069   
Domain families : Smart (EMBL)PBD (SM00285)  
Conserved Domain (NCBI)PAK4
DMDM Disease mutations10298
Blocks (Seattle)PAK4
PDB (SRS)2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B   
PDB (PDBSum)2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B   
PDB (IMB)2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B   
PDB (RSDB)2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B   
Structural Biology KnowledgeBase2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B   
SCOP (Structural Classification of Proteins)2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B   
CATH (Classification of proteins structures)2BVA    2CDZ    2J0I    2OV2    2Q0N    2X4Z    4APP    4FIE    4FIF    4FIG    4FIH    4FII    4FIJ    4JDH    4JDI    4JDJ    4JDK    4L67    4NJD    4O0V    4O0X    4O0Y    4XBR    4XBU    5BMS    5I0B   
SuperfamilyO96013
Human Protein AtlasENSG00000130669
Peptide AtlasO96013
HPRD05675
IPIIPI00014068   IPI00178714   IPI00556065   IPI00384231   IPI00477262   IPI00922679   
Protein Interaction databases
DIP (DOE-UCLA)O96013
IntAct (EBI)O96013
FunCoupENSG00000130669
BioGRIDPAK4
STRING (EMBL)PAK4
ZODIACPAK4
Ontologies - Pathways
QuickGOO96013
Ontology : AmiGOmitotic cell cycle  protein kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  Golgi apparatus  cell-cell adherens junction  focal adhesion  apoptotic process  movement of cell or subcellular component  cytoskeleton organization  signal transduction  cell proliferation  cell growth  cell migration  signal transduction by protein phosphorylation  dendritic spine development  cellular response to organic cyclic compound  cell-cell adhesion  cadherin binding involved in cell-cell adhesion  
Ontology : EGO-EBImitotic cell cycle  protein kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  Golgi apparatus  cell-cell adherens junction  focal adhesion  apoptotic process  movement of cell or subcellular component  cytoskeleton organization  signal transduction  cell proliferation  cell growth  cell migration  signal transduction by protein phosphorylation  dendritic spine development  cellular response to organic cyclic compound  cell-cell adhesion  cadherin binding involved in cell-cell adhesion  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]   
Pathways : KEGGErbB signaling pathway    Ras signaling pathway    Axon guidance    Focal adhesion    T cell receptor signaling pathway    Regulation of actin cytoskeleton    MicroRNAs in cancer    Renal cell carcinoma   
NDEx NetworkPAK4
Atlas of Cancer Signalling NetworkPAK4
Wikipedia pathwaysPAK4
Orthology - Evolution
OrthoDB10298
GeneTree (enSembl)ENSG00000130669
Phylogenetic Trees/Animal Genes : TreeFamPAK4
HOVERGENO96013
HOGENOMO96013
Homologs : HomoloGenePAK4
Homology/Alignments : Family Browser (UCSC)PAK4
Gene fusions - Rearrangements
Fusion : MitelmanPAK4/CATSPERG [19q13.2/19q13.2]  
Fusion : MitelmanPAK4/MROH7 [19q13.2/1p32.3]  [t(1;19)(p32;q13)]  
Fusion : MitelmanPAK4/SPINT2 [19q13.2/19q13.2]  [t(19;19)(q13;q13)]  
Fusion: TCGAPAK4 19q13.2 CATSPERG 19q13.2 BRCA
Fusion: TCGAPAK4 19q13.2 HEATR8 BRCA
Fusion: TCGAPAK4 19q13.2 SPINT2 19q13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPAK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PAK4
dbVarPAK4
ClinVarPAK4
1000_GenomesPAK4 
Exome Variant ServerPAK4
ExAC (Exome Aggregation Consortium)PAK4 (select the gene name)
Genetic variants : HAPMAP10298
Genomic Variants (DGV)PAK4 [DGVbeta]
DECIPHERPAK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPAK4 
Mutations
ICGC Data PortalPAK4 
TCGA Data PortalPAK4 
Broad Tumor PortalPAK4
OASIS PortalPAK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPAK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPAK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PAK4
DgiDB (Drug Gene Interaction Database)PAK4
DoCM (Curated mutations)PAK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PAK4 (select a term)
intoGenPAK4
Cancer3DPAK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605451   
Orphanet
MedgenPAK4
Genetic Testing Registry PAK4
NextProtO96013 [Medical]
TSGene10298
GENETestsPAK4
Target ValidationPAK4
Huge Navigator PAK4 [HugePedia]
snp3D : Map Gene to Disease10298
BioCentury BCIQPAK4
ClinGenPAK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10298
Chemical/Pharm GKB GenePA32920
Clinical trialPAK4
Miscellaneous
canSAR (ICR)PAK4 (select the gene name)
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePAK4
EVEXPAK4
GoPubMedPAK4
iHOPPAK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:48:24 CEST 2017

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