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PAK5 (p21 (RAC1) activated kinase 5)

Identity

Alias_namesPAK7
p21(CDKN1A)-activated kinase 7
p21 protein (Cdc42/Rac)-activated kinase 7
p21 (RAC1) activated kinase 7
Alias_symbol (synonym)KIAA1264
Other alias
HGNC (Hugo) PAK5
LocusID (NCBI) 57144
Atlas_Id 43394
Location 20p12.2  [Link to chromosome band 20p12]
Location_base_pair Starts at 9537390 and ends at 9839039 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PAK5   15916
Cards
Entrez_Gene (NCBI)PAK5  57144  p21 (RAC1) activated kinase 5
AliasesPAK7
GeneCards (Weizmann)PAK5
Ensembl hg19 (Hinxton)ENSG00000101349 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101349 [Gene_View]  chr20:9537390-9839039 [Contig_View]  PAK5 [Vega]
ICGC DataPortalENSG00000101349
TCGA cBioPortalPAK5
AceView (NCBI)PAK5
Genatlas (Paris)PAK5
WikiGenes57144
SOURCE (Princeton)PAK5
Genetics Home Reference (NIH)PAK5
Genomic and cartography
GoldenPath hg38 (UCSC)PAK5  -     chr20:9537390-9839039 -  20p12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PAK5  -     20p12.2   [Description]    (hg19-Feb_2009)
EnsemblPAK5 - 20p12.2 [CytoView hg19]  PAK5 - 20p12.2 [CytoView hg38]
Mapping of homologs : NCBIPAK5 [Mapview hg19]  PAK5 [Mapview hg38]
OMIM608038   
Gene and transcription
Genbank (Entrez)AB033090 AB040812 AK095674 AK291401 AK307926
RefSeq transcript (Entrez)NM_020341 NM_177990
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PAK5
Cluster EST : UnigeneHs.32539 [ NCBI ]
CGAP (NCI)Hs.32539
Alternative Splicing GalleryENSG00000101349
Gene ExpressionPAK5 [ NCBI-GEO ]   PAK5 [ EBI - ARRAY_EXPRESS ]   PAK5 [ SEEK ]   PAK5 [ MEM ]
Gene Expression Viewer (FireBrowse)PAK5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57144
GTEX Portal (Tissue expression)PAK5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P286   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P286  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P286
Splice isoforms : SwissVarQ9P286
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9P286
Domaine pattern : Prosite (Expaxy)CRIB (PS50108)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)CRIB_dom    Kinase-like_dom    PAK5    PAK_BD    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)PBD (PF00786)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00786    pfam00069   
Domain families : Smart (EMBL)PBD (SM00285)  
Conserved Domain (NCBI)PAK5
DMDM Disease mutations57144
Blocks (Seattle)PAK5
PDB (SRS)2F57   
PDB (PDBSum)2F57   
PDB (IMB)2F57   
PDB (RSDB)2F57   
Structural Biology KnowledgeBase2F57   
SCOP (Structural Classification of Proteins)2F57   
CATH (Classification of proteins structures)2F57   
SuperfamilyQ9P286
Human Protein AtlasENSG00000101349
Peptide AtlasQ9P286
HPRD06423
IPIIPI00001814   IPI00902566   
Protein Interaction databases
DIP (DOE-UCLA)Q9P286
IntAct (EBI)Q9P286
FunCoupENSG00000101349
BioGRIDPAK5
STRING (EMBL)PAK5
ZODIACPAK5
Ontologies - Pathways
QuickGOQ9P286
Ontology : AmiGOmitotic cell cycle  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  mitochondrion  apoptotic process  cytoskeleton organization  signal transduction  learning  memory  locomotory behavior  cell proliferation  cell growth  cell migration  signal transduction by protein phosphorylation  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBImitotic cell cycle  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  mitochondrion  apoptotic process  cytoskeleton organization  signal transduction  learning  memory  locomotory behavior  cell proliferation  cell growth  cell migration  signal transduction by protein phosphorylation  negative regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]   
NDEx NetworkPAK5
Atlas of Cancer Signalling NetworkPAK5
Wikipedia pathwaysPAK5
Orthology - Evolution
OrthoDB57144
GeneTree (enSembl)ENSG00000101349
Phylogenetic Trees/Animal Genes : TreeFamPAK5
HOVERGENQ9P286
HOGENOMQ9P286
Homologs : HomoloGenePAK5
Homology/Alignments : Family Browser (UCSC)PAK5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPAK5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PAK5
dbVarPAK5
ClinVarPAK5
1000_GenomesPAK5 
Exome Variant ServerPAK5
ExAC (Exome Aggregation Consortium)PAK5 (select the gene name)
Genetic variants : HAPMAP57144
Genomic Variants (DGV)PAK5 [DGVbeta]
DECIPHERPAK5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPAK5 
Mutations
ICGC Data PortalPAK5 
TCGA Data PortalPAK5 
Broad Tumor PortalPAK5
OASIS PortalPAK5 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPAK5
BioMutasearch PAK5
DgiDB (Drug Gene Interaction Database)PAK5
DoCM (Curated mutations)PAK5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PAK5 (select a term)
intoGenPAK5
Cancer3DPAK5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608038   
Orphanet
MedgenPAK5
Genetic Testing Registry PAK5
NextProtQ9P286 [Medical]
TSGene57144
GENETestsPAK5
Target ValidationPAK5
Huge Navigator PAK5 [HugePedia]
snp3D : Map Gene to Disease57144
BioCentury BCIQPAK5
ClinGenPAK5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57144
Chemical/Pharm GKB GenePA32922
Clinical trialPAK5
Miscellaneous
canSAR (ICR)PAK5 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePAK5
EVEXPAK5
GoPubMedPAK5
iHOPPAK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:48:24 CEST 2017

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