PAK5 (p21 (RAC1) activated kinase 5)

2006-10-01  

Identity

HGNC
LOCATION
20p12.2
LOCUSID
ALIAS
PAK7

Other Information

Locus ID:

NCBI: 57144
MIM: 608038
HGNC: 15916
Ensembl: ENSG00000101349

Variants:

dbSNP: 57144
ClinVar: 57144
TCGA: ENSG00000101349
COSMIC: PAK5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101349ENST00000353224Q9P286
ENSG00000101349ENST00000378423Q9P286
ENSG00000101349ENST00000378429Q9P286

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
Axon guidanceKEGGko04360
Focal adhesionKEGGko04510
T cell receptor signaling pathwayKEGGko04660
Regulation of actin cytoskeletonKEGGko04810
Renal cell carcinomaKEGGko05211
ErbB signaling pathwayKEGGhsa04012
Axon guidanceKEGGhsa04360
Focal adhesionKEGGhsa04510
T cell receptor signaling pathwayKEGGhsa04660
Regulation of actin cytoskeletonKEGGhsa04810
Renal cell carcinomaKEGGhsa05211
Ras signaling pathwayKEGGhsa04014
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Activation of RacREACTOMER-HSA-428540

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
160146082005PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin.30
194157462009P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration.26
240620792014Downregulation of PAK5 inhibits glioma cell migration and invasion potentially through the PAK5-Egr1-MMP2 signaling pathway.23
165817952006Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties.22
238366712013Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer.21
231069392013A role for p21-activated kinase 7 in the development of gastric cancer.20
236960252013PAK5-Egr1-MMP2 signaling controls the migration and invasion in breast cancer cell.19
261165382015miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma.18
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17

Citation

Dessen P

PAK5 (p21 (RAC1) activated kinase 5)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43394/pak5