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PAK6 (p21 protein (Cdc42/Rac)-activated kinase 6)

Identity

Other namesPAK5
HGNC (Hugo) PAK6
LocusID (NCBI) 56924
Location 15q15.1
Location_base_pair Starts at 40509629 and ends at 40569688 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PAK6   16061
Entrez_Gene (NCBI)PAK6  56924  p21 protein (Cdc42/Rac)-activated kinase 6
Cards
GeneCards (Weizmann)PAK6
Ensembl (Hinxton)ENSG00000137843 [Gene_View]  chr15:40509629-40569688 [Contig_View]  PAK6 [Vega]
AceView (NCBI)PAK6
Genatlas (Paris)PAK6
SOURCE (Stanford)NM_001128628 NM_001128629 NM_020168
Genomic and cartography
GoldenPath (UCSC)PAK6  -  15q15.1   chr15:40509629-40569688 +  15q15.1   [Description]    (hg19-Feb_2009)
EnsemblPAK6 - 15q15.1 [CytoView]
Mapping of homologs : NCBIPAK6 [Mapview]
OMIM608110   
Gene and transcription
Genbank (Entrez)AF276893 AJ236915 AK026592 AK131522 AK290227
RefSeq transcript (SRS)NM_001128628 NM_001128629 NM_020168
RefSeq transcript (Entrez)NM_001128628 NM_001128629 NM_020168
RefSeq genomic (SRS)AC_000147 NC_000015 NC_018926 NT_010194 NW_001838214 NW_004078084
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NT_010194 NW_001838214 NW_004078084
Consensus coding sequences : CCDS (NCBI)PAK6
Cluster EST : UnigeneHs.513645 [ SRS ] Hs.513645 [ NCBI ]
CGAP (NCI)Hs.513645
Alternative Splicing : Fast-db (Paris)GSHG0009768
Alternative Splicing GalleryENSG00000137843
Gene ExpressionPAK6 [ NCBI-GEO ]   PAK6 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQU5 (SRS) Q9NQU5 (Uniprot)
NextProtQ9NQU5
With graphics : InterProQ9NQU5
Splice isoforms : SwissVarQ9NQU5(Swissvar)
Domaine pattern : Prosite (SRS)CRIB (PS50108)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domaine pattern : Prosite (Expaxy)CRIB (PS50108)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (SRS)Kinase-like_dom    PAK_box_Rho-bd    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom   
Domains : Interpro (EBI)Kinase-like_dom    PAK_box_Rho-bd    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom   
Related proteins : CluSTrQ9NQU5
Domain families : Pfam (SRS)PBD (PF00786)    Pkinase (PF00069)   
Domain families : Pfam (Sanger)PBD (PF00786)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00786    pfam00069   
Domain families : Smart (EMBL)PBD (SM00285)  S_TKc (SM00220)  
DMDM56924
Blocks (Seattle)Q9NQU5
PDB (SRS)2C30    2ODB   
PDB (PDBSum)2C30    2ODB   
PDB (IMB)2C30    2ODB   
PDB (RSDB)2C30    2ODB   
Human Protein AtlasENSG00000137843
HPRD06426
IPIIPI00024584   IPI00902458   
Protein Interaction databases
DIP (DOE-UCLA)Q9NQU5
IntAct (EBI)Q9NQU5
FunCoupENSG00000137843
REACTOMEPAK6
Protein Interaction Database56924
BioGRIDPAK6
InParanoidQ9NQU5
Interologous Interaction database Q9NQU5
IntegromeDBPAK6
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PAK6
SNP (GeneSNP Utah)PAK6
SNP : HGBasePAK6
Genetic variants : HAPMAPPAK6
Somatic Mutations in Cancer : COSMICPAK6 
CONAN: Copy Number AnalysisPAK6 
Mutations and Diseases : HGMDPAK6
OMIM608110   
GENETests608110   
Disease Genetic AssociationPAK6
Huge Navigator PAK6 [HugePedia]  PAK6 [HugeCancerGEM]
Genomic VariantsPAK6  PAK6 [DGVbeta]
snp3D : Map Gene to Disease56924
General knowledge
Homologs : HomoloGenePAK6
Homology/Alignments : Family Browser (UCSC)PAK6
Phylogenetic Trees/Animal Genes : TreeFamPAK6
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Chemical/Protein Interactions : CTD56924
Chemical/Pharm GKB GenePA32921
Clinical trialPAK6
Cancer Resource (Charite)ENSG00000137843
Ontology : AmiGOprotein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  regulation of transcription, DNA-dependent  apoptotic process  cytoskeleton organization  
Ontology : EGO-EBIprotein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  regulation of transcription, DNA-dependent  apoptotic process  cytoskeleton organization  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]   
Pathways : KEGGRegulation of actin cytoskeletonT cell receptor signaling pathwayFocal adhesionAxon guidance
Other databases
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
PubGenePAK6
iHOPPAK6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:20:24 CEST 2013
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