Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PAK6 (p21 protein (Cdc42/Rac)-activated kinase 6)

Identity

Alias_namesp21(CDKN1A)-activated kinase 6
p21 protein (Cdc42/Rac)-activated kinase 6
Alias_symbol (synonym)PAK5
Other alias
HGNC (Hugo) PAK6
LocusID (NCBI) 56924
Atlas_Id 41635
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 40545379 and ends at 40569688 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PAK6   16061
Cards
Entrez_Gene (NCBI)PAK6  56924  p21 protein (Cdc42/Rac)-activated kinase 6
AliasesPAK5
GeneCards (Weizmann)PAK6
Ensembl hg19 (Hinxton)ENSG00000137843 [Gene_View]  chr15:40545379-40569688 [Contig_View]  PAK6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000137843 [Gene_View]  chr15:40545379-40569688 [Contig_View]  PAK6 [Vega]
ICGC DataPortalENSG00000137843
TCGA cBioPortalPAK6
AceView (NCBI)PAK6
Genatlas (Paris)PAK6
WikiGenes56924
SOURCE (Princeton)PAK6
Genetics Home Reference (NIH)PAK6
Genomic and cartography
GoldenPath hg19 (UCSC)PAK6  -     chr15:40545379-40569688 +  15q15.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PAK6  -     15q15.1   [Description]    (hg38-Dec_2013)
EnsemblPAK6 - 15q15.1 [CytoView hg19]  PAK6 - 15q15.1 [CytoView hg38]
Mapping of homologs : NCBIPAK6 [Mapview hg19]  PAK6 [Mapview hg38]
OMIM608110   
Gene and transcription
Genbank (Entrez)AF276893 AJ236915 AK026592 AK131522 BC035596
RefSeq transcript (Entrez)NM_001276717 NM_001276718 NM_020168
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_033169 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)PAK6
Cluster EST : UnigeneHs.745440 [ NCBI ]
CGAP (NCI)Hs.745440
Alternative Splicing GalleryENSG00000137843
Gene ExpressionPAK6 [ NCBI-GEO ]   PAK6 [ EBI - ARRAY_EXPRESS ]   PAK6 [ SEEK ]   PAK6 [ MEM ]
Gene Expression Viewer (FireBrowse)PAK6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56924
GTEX Portal (Tissue expression)PAK6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQU5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NQU5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NQU5
Splice isoforms : SwissVarQ9NQU5
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9NQU5
Domaine pattern : Prosite (Expaxy)CRIB (PS50108)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)CRIB_dom    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase   
Domain families : Pfam (Sanger)PBD (PF00786)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00786    pfam00069   
Domain families : Smart (EMBL)PBD (SM00285)  S_TKc (SM00220)  
Conserved Domain (NCBI)PAK6
DMDM Disease mutations56924
Blocks (Seattle)PAK6
PDB (SRS)2C30    2ODB    4KS7    4KS8   
PDB (PDBSum)2C30    2ODB    4KS7    4KS8   
PDB (IMB)2C30    2ODB    4KS7    4KS8   
PDB (RSDB)2C30    2ODB    4KS7    4KS8   
Structural Biology KnowledgeBase2C30    2ODB    4KS7    4KS8   
SCOP (Structural Classification of Proteins)2C30    2ODB    4KS7    4KS8   
CATH (Classification of proteins structures)2C30    2ODB    4KS7    4KS8   
SuperfamilyQ9NQU5
Human Protein AtlasENSG00000137843
Peptide AtlasQ9NQU5
HPRD06426
IPIIPI00024584   IPI00902458   
Protein Interaction databases
DIP (DOE-UCLA)Q9NQU5
IntAct (EBI)Q9NQU5
FunCoupENSG00000137843
BioGRIDPAK6
STRING (EMBL)PAK6
ZODIACPAK6
Ontologies - Pathways
QuickGOQ9NQU5
Ontology : AmiGOmitotic cell cycle  receptor signaling protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  regulation of transcription, DNA-templated  apoptotic process  cytoskeleton organization  signal transduction by protein phosphorylation  
Ontology : EGO-EBImitotic cell cycle  receptor signaling protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  regulation of transcription, DNA-templated  apoptotic process  cytoskeleton organization  signal transduction by protein phosphorylation  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]   
Pathways : KEGGErbB signaling pathway    Ras signaling pathway    Axon guidance    Focal adhesion    T cell receptor signaling pathway    Regulation of actin cytoskeleton    Renal cell carcinoma   
NDEx NetworkPAK6
Atlas of Cancer Signalling NetworkPAK6
Wikipedia pathwaysPAK6
Orthology - Evolution
OrthoDB56924
GeneTree (enSembl)ENSG00000137843
Phylogenetic Trees/Animal Genes : TreeFamPAK6
HOVERGENQ9NQU5
HOGENOMQ9NQU5
Homologs : HomoloGenePAK6
Homology/Alignments : Family Browser (UCSC)PAK6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPAK6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PAK6
dbVarPAK6
ClinVarPAK6
1000_GenomesPAK6 
Exome Variant ServerPAK6
ExAC (Exome Aggregation Consortium)PAK6 (select the gene name)
Genetic variants : HAPMAP56924
Genomic Variants (DGV)PAK6 [DGVbeta]
DECIPHER (Syndromes)15:40545379-40569688  ENSG00000137843
CONAN: Copy Number AnalysisPAK6 
Mutations
ICGC Data PortalPAK6 
TCGA Data PortalPAK6 
Broad Tumor PortalPAK6
OASIS PortalPAK6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPAK6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPAK6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PAK6
DgiDB (Drug Gene Interaction Database)PAK6
DoCM (Curated mutations)PAK6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PAK6 (select a term)
intoGenPAK6
Cancer3DPAK6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608110   
Orphanet
MedgenPAK6
Genetic Testing Registry PAK6
NextProtQ9NQU5 [Medical]
TSGene56924
GENETestsPAK6
Huge Navigator PAK6 [HugePedia]
snp3D : Map Gene to Disease56924
BioCentury BCIQPAK6
ClinGenPAK6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56924
Chemical/Pharm GKB GenePA32921
Clinical trialPAK6
Miscellaneous
canSAR (ICR)PAK6 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePAK6
EVEXPAK6
GoPubMedPAK6
iHOPPAK6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:13:27 CEST 2017

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