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PALB2 (partner and localizer of BRCA2)

Identity

Other namesFANCN
PNCA3
HGNC (Hugo) PALB2
LocusID (NCBI) 79728
Atlas_Id 46402
Location 16p12.2
Location_base_pair Starts at 23614483 and ends at 23652678 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas)
  Pancreatic tumors: an overview

Other Cancer prone implicated (Data extracted from papers in the Atlas)
  Fanconi anaemia Hereditary breast cancer Hereditary pancreatic cancer

External links

Nomenclature
HGNC (Hugo)PALB2   26144
Cards
Entrez_Gene (NCBI)PALB2  79728  partner and localizer of BRCA2
GeneCards (Weizmann)PALB2
Ensembl hg19 (Hinxton)ENSG00000083093 [Gene_View]  chr16:23614483-23652678 [Contig_View]  PALB2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000083093 [Gene_View]  chr16:23614483-23652678 [Contig_View]  PALB2 [Vega]
ICGC DataPortalENSG00000083093
TCGA cBioPortalPALB2
AceView (NCBI)PALB2
Genatlas (Paris)PALB2
WikiGenes79728
SOURCE (Princeton)PALB2
Genomic and cartography
GoldenPath hg19 (UCSC)PALB2  -     chr16:23614483-23652678 -  16p12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PALB2  -     16p12.2   [Description]    (hg38-Dec_2013)
EnsemblPALB2 - 16p12.2 [CytoView hg19]  PALB2 - 16p12.2 [CytoView hg38]
Mapping of homologs : NCBIPALB2 [Mapview hg19]  PALB2 [Mapview hg38]
OMIM114480   189960   610355   610832   613348   
Gene and transcription
Genbank (Entrez)AK025469 AK097533 AK299152 AL834425 BC044254
RefSeq transcript (Entrez)NM_024675
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_007406 NT_187260 NW_004929400
Consensus coding sequences : CCDS (NCBI)PALB2
Cluster EST : UnigeneHs.444664 [ NCBI ]
CGAP (NCI)Hs.444664
Alternative Splicing : Fast-db (Paris)GSHG0011714
Alternative Splicing GalleryENSG00000083093
Gene ExpressionPALB2 [ NCBI-GEO ]     PALB2 [ SEEK ]   PALB2 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)79728
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86YC2 (Uniprot)
NextProtQ86YC2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86YC2
Splice isoforms : SwissVarQ86YC2 (Swissvar)
PhosPhoSitePlusQ86YC2
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom    WD40_repeat_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
DMDM Disease mutations79728
Blocks (Seattle)PALB2
PDB (SRS)2W18    3EU7   
PDB (PDBSum)2W18    3EU7   
PDB (IMB)2W18    3EU7   
PDB (RSDB)2W18    3EU7   
Structural Biology KnowledgeBase2W18    3EU7   
SCOP (Structural Classification of Proteins)2W18    3EU7   
CATH (Classification of proteins structures)2W18    3EU7   
Human Protein AtlasENSG00000083093
Peptide AtlasQ86YC2
HPRD07966
IPIIPI00172559   
Protein Interaction databases
DIP (DOE-UCLA)Q86YC2
IntAct (EBI)Q86YC2
FunCoupENSG00000083093
BioGRIDPALB2
IntegromeDBPALB2
STRING (EMBL)PALB2
ZODIACPALB2
Ontologies - Pathways
QuickGOQ86YC2
Ontology : AmiGOdouble-strand break repair via homologous recombination  double-strand break repair via homologous recombination  somitogenesis  inner cell mass cell proliferation  DNA binding  protein binding  nucleoplasm  nucleoplasm  DNA repair  double-strand break repair  mesoderm development  organ morphogenesis  chromosome breakage  multicellular organism growth  post-anal tail morphogenesis  negative regulation of apoptotic process  double-strand break repair via synthesis-dependent strand annealing  embryonic organ development  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  double-strand break repair via homologous recombination  somitogenesis  inner cell mass cell proliferation  DNA binding  protein binding  nucleoplasm  nucleoplasm  DNA repair  double-strand break repair  mesoderm development  organ morphogenesis  chromosome breakage  multicellular organism growth  post-anal tail morphogenesis  negative regulation of apoptotic process  double-strand break repair via synthesis-dependent strand annealing  embryonic organ development  
Pathways : KEGGFanconi anemia pathway   
Protein Interaction DatabasePALB2
Atlas of Cancer Signalling NetworkPALB2
Wikipedia pathwaysPALB2
Orthology - Evolution
OrthoDB79728
GeneTree (enSembl)ENSG00000083093
Phylogenetic Trees/Animal Genes : TreeFamPALB2
Homologs : HomoloGenePALB2
Homology/Alignments : Family Browser (UCSC)PALB2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPALB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PALB2
dbVarPALB2
ClinVarPALB2
1000_GenomesPALB2 
Exome Variant ServerPALB2
Exome Aggregation Consortium (ExAC)ENSG00000083093
SNP (GeneSNP Utah)PALB2
SNP : HGBasePALB2
Genetic variants : HAPMAPPALB2
Genomic Variants (DGV)PALB2 [DGVbeta]
Mutations
ICGC Data PortalPALB2 
TCGA Data PortalPALB2 
Tumor PortalPALB2
TCGA Copy Number PortalPALB2
Cancer Gene: CensusPALB2 
Somatic Mutations in Cancer : COSMICPALB2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch PALB2
DgiDB (Drug Gene Interaction Database)PALB2
DoCM (Curated mutations)PALB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PALB2 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)16:23614483-23652678
CONAN: Copy Number AnalysisPALB2 
Mutations and Diseases : HGMDPALB2
OMIM114480    189960    610355    610832    613348   
MedgenPALB2
NextProtQ86YC2 [Medical]
TSGene79728
GENETestsPALB2
Huge Navigator PALB2 [HugePedia]  PALB2 [HugeCancerGEM]
snp3D : Map Gene to Disease79728
BioCentury BCIQPALB2
General knowledge
Chemical/Protein Interactions : CTD79728
Chemical/Pharm GKB GenePA162398608
Clinical trialPALB2
Other databases
Probes
Litterature
PubMed130 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePALB2
GoPubMedPALB2
iHOPPALB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Jan 16 19:12:11 CET 2016

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