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PALB2 (partner and localizer of BRCA2)

Identity

Alias_namescomplementation group N
Alias_symbol (synonym)FLJ21816
FANCN
HGNC (Hugo) PALB2
LocusID (NCBI) 79728
Atlas_Id 46402
Location 16p12.2  [Link to chromosome band 16p12]
Location_base_pair Starts at 23614483 and ends at 23652678 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Pancreatic tumors: an overview


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 4 ]
  Fanconi anemia Familial Myeloproliferative Disorders Hereditary breast cancer Hereditary pancreatic cancer


External links

Nomenclature
HGNC (Hugo)PALB2   26144
LRG (Locus Reference Genomic)LRG_308
Cards
Entrez_Gene (NCBI)PALB2  79728  partner and localizer of BRCA2
AliasesFANCN; PNCA3
GeneCards (Weizmann)PALB2
Ensembl hg19 (Hinxton)ENSG00000083093 [Gene_View]  chr16:23614483-23652678 [Contig_View]  PALB2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000083093 [Gene_View]  chr16:23614483-23652678 [Contig_View]  PALB2 [Vega]
ICGC DataPortalENSG00000083093
TCGA cBioPortalPALB2
AceView (NCBI)PALB2
Genatlas (Paris)PALB2
WikiGenes79728
SOURCE (Princeton)PALB2
Genetics Home Reference (NIH)PALB2
Genomic and cartography
GoldenPath hg19 (UCSC)PALB2  -     chr16:23614483-23652678 -  16p12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PALB2  -     16p12.2   [Description]    (hg38-Dec_2013)
EnsemblPALB2 - 16p12.2 [CytoView hg19]  PALB2 - 16p12.2 [CytoView hg38]
Mapping of homologs : NCBIPALB2 [Mapview hg19]  PALB2 [Mapview hg38]
OMIM114480   189960   610355   610832   613348   
Gene and transcription
Genbank (Entrez)AK025469 AK097533 AK299152 AL834425 BC044254
RefSeq transcript (Entrez)NM_024675
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_007406 NT_187260 NW_004929400
Consensus coding sequences : CCDS (NCBI)PALB2
Cluster EST : UnigeneHs.444664 [ NCBI ]
CGAP (NCI)Hs.444664
Alternative Splicing GalleryENSG00000083093
Gene ExpressionPALB2 [ NCBI-GEO ]   PALB2 [ EBI - ARRAY_EXPRESS ]   PALB2 [ SEEK ]   PALB2 [ MEM ]
Gene Expression Viewer (FireBrowse)PALB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79728
GTEX Portal (Tissue expression)PALB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86YC2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86YC2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86YC2
Splice isoforms : SwissVarQ86YC2
PhosPhoSitePlusQ86YC2
Domains : Interpro (EBI)PALB2_WD40    WD40/YVTN_repeat-like_dom    WD40_repeat_dom   
Domain families : Pfam (Sanger)PALB2_WD40 (PF16756)   
Domain families : Pfam (NCBI)pfam16756   
Conserved Domain (NCBI)PALB2
DMDM Disease mutations79728
Blocks (Seattle)PALB2
PDB (SRS)2W18    3EU7   
PDB (PDBSum)2W18    3EU7   
PDB (IMB)2W18    3EU7   
PDB (RSDB)2W18    3EU7   
Structural Biology KnowledgeBase2W18    3EU7   
SCOP (Structural Classification of Proteins)2W18    3EU7   
CATH (Classification of proteins structures)2W18    3EU7   
SuperfamilyQ86YC2
Human Protein AtlasENSG00000083093
Peptide AtlasQ86YC2
HPRD07966
IPIIPI00172559   
Protein Interaction databases
DIP (DOE-UCLA)Q86YC2
IntAct (EBI)Q86YC2
FunCoupENSG00000083093
BioGRIDPALB2
STRING (EMBL)PALB2
ZODIACPALB2
Ontologies - Pathways
QuickGOQ86YC2
Ontology : AmiGOdouble-strand break repair via homologous recombination  DNA synthesis involved in DNA repair  strand displacement  somitogenesis  inner cell mass cell proliferation  DNA binding  protein binding  nucleoplasm  nucleoplasm  mesoderm development  organ morphogenesis  chromosome breakage  multicellular organism growth  post-anal tail morphogenesis  negative regulation of apoptotic process  embryonic organ development  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  DNA synthesis involved in DNA repair  strand displacement  somitogenesis  inner cell mass cell proliferation  DNA binding  protein binding  nucleoplasm  nucleoplasm  mesoderm development  organ morphogenesis  chromosome breakage  multicellular organism growth  post-anal tail morphogenesis  negative regulation of apoptotic process  embryonic organ development  
Pathways : KEGGFanconi anemia pathway   
NDEx NetworkPALB2
Atlas of Cancer Signalling NetworkPALB2
Wikipedia pathwaysPALB2
Orthology - Evolution
OrthoDB79728
GeneTree (enSembl)ENSG00000083093
Phylogenetic Trees/Animal Genes : TreeFamPALB2
HOVERGENQ86YC2
HOGENOMQ86YC2
Homologs : HomoloGenePALB2
Homology/Alignments : Family Browser (UCSC)PALB2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPALB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PALB2
dbVarPALB2
ClinVarPALB2
1000_GenomesPALB2 
Exome Variant ServerPALB2
ExAC (Exome Aggregation Consortium)PALB2 (select the gene name)
Genetic variants : HAPMAP79728
Genomic Variants (DGV)PALB2 [DGVbeta]
DECIPHER (Syndromes)16:23614483-23652678  ENSG00000083093
CONAN: Copy Number AnalysisPALB2 
Mutations
ICGC Data PortalPALB2 
TCGA Data PortalPALB2 
Broad Tumor PortalPALB2
OASIS PortalPALB2 [ Somatic mutations - Copy number]
Cancer Gene: CensusPALB2 
Somatic Mutations in Cancer : COSMICPALB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPALB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch PALB2
DgiDB (Drug Gene Interaction Database)PALB2
DoCM (Curated mutations)PALB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PALB2 (select a term)
intoGenPALB2
Cancer3DPALB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114480    189960    610355    610832    613348   
Orphanet634    3384    19054    3708   
MedgenPALB2
Genetic Testing Registry PALB2
NextProtQ86YC2 [Medical]
TSGene79728
GENETestsPALB2
Huge Navigator PALB2 [HugePedia]
snp3D : Map Gene to Disease79728
BioCentury BCIQPALB2
ClinGenPALB2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79728
Chemical/Pharm GKB GenePA162398608
Clinical trialPALB2
Miscellaneous
canSAR (ICR)PALB2 (select the gene name)
Probes
Litterature
PubMed135 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePALB2
EVEXPALB2
GoPubMedPALB2
iHOPPALB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:46:47 CET 2016

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