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PAM (peptidylglycine alpha-amidating monooxygenase)

Identity

Alias_symbol (synonym)PAL
PHM
Other alias
HGNC (Hugo) PAM
LocusID (NCBI) 5066
Atlas_Id 41636
Location 5q21.1  [Link to chromosome band 5q21]
Location_base_pair Starts at 102201527 and ends at 102366808 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C5orf30 (5q21.1) / PAM (5q21.1)PAM (5q21.1) / GOLGA3 (12q24.33)PAM (5q21.1) / PAM (5q21.1)
RPH3AL (17p13.3) / PAM (5q21.1)ST8SIA4 (5q21.1) / PAM (5q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PAM   8596
Cards
Entrez_Gene (NCBI)PAM  5066  peptidylglycine alpha-amidating monooxygenase
AliasesPAL; PHM
GeneCards (Weizmann)PAM
Ensembl hg19 (Hinxton)ENSG00000145730 [Gene_View]  chr5:102201527-102366808 [Contig_View]  PAM [Vega]
Ensembl hg38 (Hinxton)ENSG00000145730 [Gene_View]  chr5:102201527-102366808 [Contig_View]  PAM [Vega]
ICGC DataPortalENSG00000145730
TCGA cBioPortalPAM
AceView (NCBI)PAM
Genatlas (Paris)PAM
WikiGenes5066
SOURCE (Princeton)PAM
Genetics Home Reference (NIH)PAM
Genomic and cartography
GoldenPath hg19 (UCSC)PAM  -     chr5:102201527-102366808 +  5q21.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PAM  -     5q21.1   [Description]    (hg38-Dec_2013)
EnsemblPAM - 5q21.1 [CytoView hg19]  PAM - 5q21.1 [CytoView hg38]
Mapping of homologs : NCBIPAM [Mapview hg19]  PAM [Mapview hg38]
OMIM170270   
Gene and transcription
Genbank (Entrez)AB095007 AF010472 AF035320 AK290158 AK296521
RefSeq transcript (Entrez)NM_000919 NM_001177306 NM_001319943 NM_138766 NM_138821 NM_138822
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_029444 NT_034772 NW_004929323
Consensus coding sequences : CCDS (NCBI)PAM
Cluster EST : UnigeneHs.369430 [ NCBI ]
CGAP (NCI)Hs.369430
Alternative Splicing GalleryENSG00000145730
Gene ExpressionPAM [ NCBI-GEO ]   PAM [ EBI - ARRAY_EXPRESS ]   PAM [ SEEK ]   PAM [ MEM ]
Gene Expression Viewer (FireBrowse)PAM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5066
GTEX Portal (Tissue expression)PAM
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19021   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19021  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19021
Splice isoforms : SwissVarP19021
Catalytic activity : Enzyme1.14.17.3 [ Enzyme-Expasy ]   1.14.17.31.14.17.3 [ IntEnz-EBI ]   1.14.17.3 [ BRENDA ]   1.14.17.3 [ KEGG ]   
PhosPhoSitePlusP19021
Domaine pattern : Prosite (Expaxy)CU2_MONOOXYGENASE_1 (PS00084)    CU2_MONOOXYGENASE_2 (PS00085)    NHL (PS51125)   
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like    Cu2_ascorb_mOase-like_C    Cu2_ascorb_mOase_CS-1    Cu2_ascorb_mOase_CS-2    Cu2_ascorb_mOase_N    Cu2_monoox_C    NHL_repeat    NHL_repeat_subgr    PAM/PAL    PHM/PNGase_F_dom   
Domain families : Pfam (Sanger)Cu2_monoox_C (PF03712)    Cu2_monooxygen (PF01082)    NHL (PF01436)   
Domain families : Pfam (NCBI)pfam03712    pfam01082    pfam01436   
Conserved Domain (NCBI)PAM
DMDM Disease mutations5066
Blocks (Seattle)PAM
SuperfamilyP19021
Human Protein AtlasENSG00000145730
Peptide AtlasP19021
HPRD01361
IPIIPI00940221   IPI00878690   IPI00219042   IPI00219043   IPI00177543   IPI00749176   IPI00816123   IPI00040158   IPI00965201   IPI00964274   IPI00966082   IPI00966418   IPI00966989   IPI00965752   IPI00967603   IPI00966047   
Protein Interaction databases
DIP (DOE-UCLA)P19021
IntAct (EBI)P19021
FunCoupENSG00000145730
BioGRIDPAM
STRING (EMBL)PAM
ZODIACPAM
Ontologies - Pathways
QuickGOP19021
Ontology : AmiGOpeptide amidation  response to hypoxia  long-chain fatty acid metabolic process  peptidylglycine monooxygenase activity  peptidylamidoglycolate lyase activity  copper ion binding  calcium ion binding  protein binding  extracellular space  trans-Golgi network  plasma membrane  regulation of transcription from RNA polymerase II promoter  central nervous system development  heart development  lactation  zinc ion binding  response to pH  toxin metabolic process  cell surface  membrane  integral component of membrane  protein amidation  protein kinase binding  ovulation cycle process  secretory granule membrane  L-ascorbic acid binding  response to estradiol  regulation of actin cytoskeleton organization  odontogenesis  response to drug  neuron projection  perikaryon  response to copper ion  perinuclear region of cytoplasm  regulation of protein secretion  protein homooligomerization  response to glucocorticoid  oxidation-reduction process  maternal process involved in female pregnancy  limb development  extracellular exosome  
Ontology : EGO-EBIpeptide amidation  response to hypoxia  long-chain fatty acid metabolic process  peptidylglycine monooxygenase activity  peptidylamidoglycolate lyase activity  copper ion binding  calcium ion binding  protein binding  extracellular space  trans-Golgi network  plasma membrane  regulation of transcription from RNA polymerase II promoter  central nervous system development  heart development  lactation  zinc ion binding  response to pH  toxin metabolic process  cell surface  membrane  integral component of membrane  protein amidation  protein kinase binding  ovulation cycle process  secretory granule membrane  L-ascorbic acid binding  response to estradiol  regulation of actin cytoskeleton organization  odontogenesis  response to drug  neuron projection  perikaryon  response to copper ion  perinuclear region of cytoplasm  regulation of protein secretion  protein homooligomerization  response to glucocorticoid  oxidation-reduction process  maternal process involved in female pregnancy  limb development  extracellular exosome  
NDEx NetworkPAM
Atlas of Cancer Signalling NetworkPAM
Wikipedia pathwaysPAM
Orthology - Evolution
OrthoDB5066
GeneTree (enSembl)ENSG00000145730
Phylogenetic Trees/Animal Genes : TreeFamPAM
HOVERGENP19021
HOGENOMP19021
Homologs : HomoloGenePAM
Homology/Alignments : Family Browser (UCSC)PAM
Gene fusions - Rearrangements
Fusion : MitelmanST8SIA4/PAM [5q21.1/5q21.1]  [t(5;5)(q21;q21)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPAM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PAM
dbVarPAM
ClinVarPAM
1000_GenomesPAM 
Exome Variant ServerPAM
ExAC (Exome Aggregation Consortium)PAM (select the gene name)
Genetic variants : HAPMAP5066
Genomic Variants (DGV)PAM [DGVbeta]
DECIPHER (Syndromes)5:102201527-102366808  ENSG00000145730
CONAN: Copy Number AnalysisPAM 
Mutations
ICGC Data PortalPAM 
TCGA Data PortalPAM 
Broad Tumor PortalPAM
OASIS PortalPAM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPAM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPAM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PAM
DgiDB (Drug Gene Interaction Database)PAM
DoCM (Curated mutations)PAM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PAM (select a term)
intoGenPAM
Cancer3DPAM(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM170270   
Orphanet
MedgenPAM
Genetic Testing Registry PAM
NextProtP19021 [Medical]
TSGene5066
GENETestsPAM
Huge Navigator PAM [HugePedia]
snp3D : Map Gene to Disease5066
BioCentury BCIQPAM
ClinGenPAM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5066
Chemical/Pharm GKB GenePA32926
Clinical trialPAM
Miscellaneous
canSAR (ICR)PAM (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePAM
EVEXPAM
GoPubMedPAM
iHOPPAM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:13:28 CEST 2017

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