PAN2 (poly(A) specific ribonuclease subunit PAN2)

2014-11-01  

Identity

HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
USP52
FUSION GENES

Other Information

Locus ID:

NCBI: 9924
MIM: 617447
HGNC: 20074
Ensembl: ENSG00000135473

Variants:

dbSNP: 9924
ClinVar: 9924
TCGA: ENSG00000135473
COSMIC: PAN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135473ENST00000257931Q504Q3
ENSG00000135473ENST00000425394Q504Q3
ENSG00000135473ENST00000440411Q504Q3
ENSG00000135473ENST00000547572F8VXK8
ENSG00000135473ENST00000548043Q504Q3
ENSG00000135473ENST00000610546Q504Q3

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
145836022004Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein.45
233984562013The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.24
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
295994862018USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization.6

Citation

Dessen P

PAN2 (poly(A) specific ribonuclease subunit PAN2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71644/pan2