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PAN2 (poly(A) specific ribonuclease subunit PAN2)

Identity

Alias (NCBI)USP52
HGNC (Hugo) PAN2
HGNC Alias symbKIAA0710
hPAN2
HGNC Alias namePAN2 homolog, PABP1 dependent poly A specific ribonuclease subunit (S. cerevisiae)
HGNC Previous nameUSP52
HGNC Previous nameubiquitin specific protease 52
 ubiquitin specific peptidase 52
 PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
LocusID (NCBI) 9924
Atlas_Id 71644
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 56316223 and ends at 56334053 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PAN2 (12q13.3) / MIP (12q13.3)RP11-977G19.10 () / PAN2 (12q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  PAN2/MIP (12q13)

External links

Nomenclature
HGNC (Hugo)PAN2   20074
Cards
Entrez_Gene (NCBI)PAN2  9924  poly(A) specific ribonuclease subunit PAN2
AliasesUSP52
GeneCards (Weizmann)PAN2
Ensembl hg19 (Hinxton)ENSG00000135473 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135473 [Gene_View]  ENSG00000135473 [Sequence]  chr12:56316223-56334053 [Contig_View]  PAN2 [Vega]
ICGC DataPortalENSG00000135473
TCGA cBioPortalPAN2
AceView (NCBI)PAN2
Genatlas (Paris)PAN2
WikiGenes9924
SOURCE (Princeton)PAN2
Genetics Home Reference (NIH)PAN2
Genomic and cartography
GoldenPath hg38 (UCSC)PAN2  -     chr12:56316223-56334053 -  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PAN2  -     12q13.3   [Description]    (hg19-Feb_2009)
GoldenPathPAN2 - 12q13.3 [CytoView hg19]  PAN2 - 12q13.3 [CytoView hg38]
ImmunoBaseENSG00000135473
genome Data Viewer NCBIPAN2 [Mapview hg19]  
OMIM617447   
Gene and transcription
Genbank (Entrez)AB014610 AB107585 AK001232 AK096679 AK310822
RefSeq transcript (Entrez)NM_001127460 NM_001166279 NM_014871
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PAN2
Alternative Splicing GalleryENSG00000135473
Gene ExpressionPAN2 [ NCBI-GEO ]   PAN2 [ EBI - ARRAY_EXPRESS ]   PAN2 [ SEEK ]   PAN2 [ MEM ]
Gene Expression Viewer (FireBrowse)PAN2 [ Firebrowse - Broad ]
GenevisibleExpression of PAN2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9924
GTEX Portal (Tissue expression)PAN2
Human Protein AtlasENSG00000135473-PAN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ504Q3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ504Q3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ504Q3
Splice isoforms : SwissVarQ504Q3
PhosPhoSitePlusQ504Q3
Domaine pattern : Prosite (Expaxy)USP_3 (PS50235)   
Domains : Interpro (EBI)Exonuclease_RNaseT/DNA_pol3    PAN2    PAN2_dom    Papain-like_cys_pep_sf    RNaseH-like_sf    RNaseH_sf    USP_dom    WD40/YVTN_repeat-like_dom_sf    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)RNase_T (PF00929)    UCH_1 (PF13423)   
Domain families : Pfam (NCBI)pfam00929    pfam13423   
Domain families : Smart (EMBL)EXOIII (SM00479)  
Conserved Domain (NCBI)PAN2
DMDM Disease mutations9924
Blocks (Seattle)PAN2
SuperfamilyQ504Q3
Human Protein Atlas [tissue]ENSG00000135473-PAN2 [tissue]
Peptide AtlasQ504Q3
HPRD15640
IPIIPI00747362   IPI00328254   IPI00796020   IPI01022232   
Protein Interaction databases
DIP (DOE-UCLA)Q504Q3
IntAct (EBI)Q504Q3
FunCoupENSG00000135473
BioGRIDPAN2
STRING (EMBL)PAN2
ZODIACPAN2
Ontologies - Pathways
QuickGOQ504Q3
Ontology : AmiGO3'-5'-exoribonuclease activity  nuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  P-body  nucleic acid binding  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  protein binding  nucleus  cytosol  mRNA processing  positive regulation of cytoplasmic mRNA processing body assembly  PAN complex  PAN complex  metal ion binding  RNA phosphodiester bond hydrolysis, exonucleolytic  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  nuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  P-body  nucleic acid binding  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  protein binding  nucleus  cytosol  mRNA processing  positive regulation of cytoplasmic mRNA processing body assembly  PAN complex  PAN complex  metal ion binding  RNA phosphodiester bond hydrolysis, exonucleolytic  
NDEx NetworkPAN2
Atlas of Cancer Signalling NetworkPAN2
Wikipedia pathwaysPAN2
Orthology - Evolution
OrthoDB9924
GeneTree (enSembl)ENSG00000135473
Phylogenetic Trees/Animal Genes : TreeFamPAN2
HOGENOMQ504Q3
Homologs : HomoloGenePAN2
Homology/Alignments : Family Browser (UCSC)PAN2
Gene fusions - Rearrangements
Fusion : QuiverPAN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPAN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PAN2
dbVarPAN2
ClinVarPAN2
1000_GenomesPAN2 
Exome Variant ServerPAN2
GNOMAD BrowserENSG00000135473
Varsome BrowserPAN2
Genetic variants : HAPMAP9924
Genomic Variants (DGV)PAN2 [DGVbeta]
DECIPHERPAN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPAN2 
Mutations
ICGC Data PortalPAN2 
TCGA Data PortalPAN2 
Broad Tumor PortalPAN2
OASIS PortalPAN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPAN2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPAN2
Mutations and Diseases : HGMDPAN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PAN2
DgiDB (Drug Gene Interaction Database)PAN2
DoCM (Curated mutations)PAN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PAN2 (select a term)
intoGenPAN2
Cancer3DPAN2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617447   
Orphanet
DisGeNETPAN2
MedgenPAN2
Genetic Testing Registry PAN2
NextProtQ504Q3 [Medical]
TSGene9924
GENETestsPAN2
Target ValidationPAN2
Huge Navigator PAN2 [HugePedia]
snp3D : Map Gene to Disease9924
BioCentury BCIQPAN2
ClinGenPAN2
Clinical trials, drugs, therapy
Protein Interactions : CTD9924
Pharm GKB GenePA162398664
Clinical trialPAN2
Miscellaneous
canSAR (ICR)PAN2 (select the gene name)
HarmonizomePAN2
DataMed IndexPAN2
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePAN2
EVEXPAN2
GoPubMedPAN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 16:22:16 CEST 2020
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