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PAN3 (poly(A) specific ribonuclease subunit PAN3)

Identity

Alias_namesPAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
Other alias-
HGNC (Hugo) PAN3
LocusID (NCBI) 255967
Atlas_Id 54525
Location 13q12.2  [Link to chromosome band 13q12]
Location_base_pair Starts at 28138506 and ends at 28295338 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCT2 (12q15) / PAN3 (13q12.2)CENPJ (13q12.12) / PAN3 (13q12.2)EPC2 (2q23.1) / PAN3 (13q12.2)
PAN3 (13q12.2) / CENPJ (13q12.12)PAN3 (13q12.2) / HSDL2 (9q32)PAN3 (13q12.2) / NTRK2 (9q21.33)
PAN3 (13q12.2) / PAN3 (13q12.2)PAN3 (13q12.2) / RAPGEF5 (7p15.3)PAN3 (13q12.2) / RFC3 (13q13.2)
UBL3 (13q12.3) / PAN3 (13q12.2)PAN3 13q12.2 / NTRK2 9q21.33UBL3 13q12.3 / PAN3 13q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  del(13)(q12q13) PAN3/RFC3
t(9;13)(q21;q12) PAN3/NTRK2
UBL3/PAN3 (13q12)

External links

Nomenclature
HGNC (Hugo)PAN3   29991
Cards
Entrez_Gene (NCBI)PAN3  255967  poly(A) specific ribonuclease subunit PAN3
Aliases
GeneCards (Weizmann)PAN3
Ensembl hg19 (Hinxton)ENSG00000152520 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152520 [Gene_View]  ENSG00000152520 [Sequence]  chr13:28138506-28295338 [Contig_View]  PAN3 [Vega]
ICGC DataPortalENSG00000152520
TCGA cBioPortalPAN3
AceView (NCBI)PAN3
Genatlas (Paris)PAN3
WikiGenes255967
SOURCE (Princeton)PAN3
Genetics Home Reference (NIH)PAN3
Genomic and cartography
GoldenPath hg38 (UCSC)PAN3  -     chr13:28138506-28295338 +  13q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PAN3  -     13q12.2   [Description]    (hg19-Feb_2009)
EnsemblPAN3 - 13q12.2 [CytoView hg19]  PAN3 - 13q12.2 [CytoView hg38]
Mapping of homologs : NCBIPAN3 [Mapview hg19]  PAN3 [Mapview hg38]
OMIM617448   
Gene and transcription
Genbank (Entrez)AB107584 AB109552 AK091307 AK131556 AK296435
RefSeq transcript (Entrez)NM_175854
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PAN3
Cluster EST : UnigeneHs.645015 [ NCBI ]
CGAP (NCI)Hs.645015
Alternative Splicing GalleryENSG00000152520
Gene ExpressionPAN3 [ NCBI-GEO ]   PAN3 [ EBI - ARRAY_EXPRESS ]   PAN3 [ SEEK ]   PAN3 [ MEM ]
Gene Expression Viewer (FireBrowse)PAN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)255967
GTEX Portal (Tissue expression)PAN3
Human Protein AtlasENSG00000152520-PAN3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ58A45   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ58A45  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ58A45
Splice isoforms : SwissVarQ58A45
PhosPhoSitePlusQ58A45
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)Kinase-like_dom_sf    PAN3    Prot_kinase_dom    Znf_CCCH    Znf_CCCH_sf   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)PAN3
DMDM Disease mutations255967
Blocks (Seattle)PAN3
SuperfamilyQ58A45
Human Protein Atlas [tissue]ENSG00000152520-PAN3 [tissue]
Peptide AtlasQ58A45
HPRD17818
IPIIPI00513919   IPI00829672   IPI00954802   IPI01022195   IPI00432669   
Protein Interaction databases
DIP (DOE-UCLA)Q58A45
IntAct (EBI)Q58A45
FunCoupENSG00000152520
BioGRIDPAN3
STRING (EMBL)PAN3
ZODIACPAN3
Ontologies - Pathways
QuickGOQ58A45
Ontology : AmiGOnuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  deadenylation-dependent decapping of nuclear-transcribed mRNA  P-body  RNA binding  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  protein kinase activity  protein binding  ATP binding  cytosol  mRNA processing  protein phosphorylation  protein targeting  positive regulation of cytoplasmic mRNA processing body assembly  PAN complex  PAN complex  metal ion binding  RNA phosphodiester bond hydrolysis, exonucleolytic  
Ontology : EGO-EBInuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  deadenylation-dependent decapping of nuclear-transcribed mRNA  P-body  RNA binding  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  protein kinase activity  protein binding  ATP binding  cytosol  mRNA processing  protein phosphorylation  protein targeting  positive regulation of cytoplasmic mRNA processing body assembly  PAN complex  PAN complex  metal ion binding  RNA phosphodiester bond hydrolysis, exonucleolytic  
Pathways : KEGGRNA degradation   
NDEx NetworkPAN3
Atlas of Cancer Signalling NetworkPAN3
Wikipedia pathwaysPAN3
Orthology - Evolution
OrthoDB255967
GeneTree (enSembl)ENSG00000152520
Phylogenetic Trees/Animal Genes : TreeFamPAN3
HOVERGENQ58A45
HOGENOMQ58A45
Homologs : HomoloGenePAN3
Homology/Alignments : Family Browser (UCSC)PAN3
Gene fusions - Rearrangements
Fusion : MitelmanPAN3/NTRK2 [13q12.2/9q21.33]  
Fusion : MitelmanPAN3/RFC3 [13q12.2/13q13.2]  [del(13)(q12q13)]  
Fusion : MitelmanUBL3/PAN3 [13q12.3/13q12.2]  [t(13;13)(q12;q12)]  
Fusion PortalPAN3 13q12.2 NTRK2 9q21.33 HNSC
Fusion PortalUBL3 13q12.3 PAN3 13q12.2 BRCA
Fusion Cancer (Beijing)CENPJ [13q12.12]  -  PAN3 [13q12.2]  [FUSC000139]
Fusion Cancer (Beijing)PAN3 [13q12.2]  -  CENPJ [13q12.12]  [FUSC000146]  [FUSC000146]
Fusion : QuiverPAN3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPAN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PAN3
dbVarPAN3
ClinVarPAN3
1000_GenomesPAN3 
Exome Variant ServerPAN3
ExAC (Exome Aggregation Consortium)ENSG00000152520
GNOMAD BrowserENSG00000152520
Varsome BrowserPAN3
Genetic variants : HAPMAP255967
Genomic Variants (DGV)PAN3 [DGVbeta]
DECIPHERPAN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPAN3 
Mutations
ICGC Data PortalPAN3 
TCGA Data PortalPAN3 
Broad Tumor PortalPAN3
OASIS PortalPAN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPAN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPAN3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PAN3
DgiDB (Drug Gene Interaction Database)PAN3
DoCM (Curated mutations)PAN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PAN3 (select a term)
intoGenPAN3
Cancer3DPAN3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617448   
Orphanet
DisGeNETPAN3
MedgenPAN3
Genetic Testing Registry PAN3
NextProtQ58A45 [Medical]
TSGene255967
GENETestsPAN3
Target ValidationPAN3
Huge Navigator PAN3 [HugePedia]
snp3D : Map Gene to Disease255967
BioCentury BCIQPAN3
ClinGenPAN3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD255967
Chemical/Pharm GKB GenePA144596398
Clinical trialPAN3
Miscellaneous
canSAR (ICR)PAN3 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePAN3
EVEXPAN3
GoPubMedPAN3
iHOPPAN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:42:44 CEST 2018
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