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PANK1 (pantothenate kinase 1)

Identity

Alias (NCBI)PANK
HGNC (Hugo) PANK1
HGNC Alias symbMGC24596
PANK1a
PANK1b
HGNC Previous namePANK
HGNC Previous namepantothenate kinase
LocusID (NCBI) 53354
Atlas_Id 71647
Location 10q23.31  [Link to chromosome band 10q23]
Location_base_pair Starts at 89579495 and ends at 89643916 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PANK1 (10q23.31) / C8orf34 (8q13.2)PANK1 (10q23.31) / PDK3 (Xp22.11)TRDMT1 (10p13) / PANK1 (10q23.31)
PANK1 C8orf34PANK1 PDK3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PANK1   8598
Cards
Entrez_Gene (NCBI)PANK1    pantothenate kinase 1
AliasesPANK
GeneCards (Weizmann)PANK1
Ensembl hg19 (Hinxton)ENSG00000152782 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152782 [Gene_View]  ENSG00000152782 [Sequence]  chr10:89579495-89643916 [Contig_View]  PANK1 [Vega]
ICGC DataPortalENSG00000152782
TCGA cBioPortalPANK1
AceView (NCBI)PANK1
Genatlas (Paris)PANK1
SOURCE (Princeton)PANK1
Genetics Home Reference (NIH)PANK1
Genomic and cartography
GoldenPath hg38 (UCSC)PANK1  -     chr10:89579495-89643916 -  10q23.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PANK1  -     10q23.31   [Description]    (hg19-Feb_2009)
GoldenPathPANK1 - 10q23.31 [CytoView hg19]  PANK1 - 10q23.31 [CytoView hg38]
ImmunoBaseENSG00000152782
Genome Data Viewer NCBIPANK1 [Mapview hg19]  
OMIM606160   
Gene and transcription
Genbank (Entrez)AF355198 AK057932 AK125428 AK127777 AY027661
RefSeq transcript (Entrez)NM_138316 NM_148977 NM_148978
Consensus coding sequences : CCDS (NCBI)PANK1
Gene ExpressionPANK1 [ NCBI-GEO ]   PANK1 [ EBI - ARRAY_EXPRESS ]   PANK1 [ SEEK ]   PANK1 [ MEM ]
Gene Expression Viewer (FireBrowse)PANK1 [ Firebrowse - Broad ]
GenevisibleExpression of PANK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53354
GTEX Portal (Tissue expression)PANK1
Human Protein AtlasENSG00000152782-PANK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TE04   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TE04  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TE04
Catalytic activity : Enzyme2.7.1.33 [ Enzyme-Expasy ]   2.7.1.332.7.1.33 [ IntEnz-EBI ]   2.7.1.33 [ BRENDA ]   2.7.1.33 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ8TE04
Domains : Interpro (EBI)ATPase_NBD    Type_II_PanK   
Domain families : Pfam (Sanger)Fumble (PF03630)   
Domain families : Pfam (NCBI)pfam03630   
Conserved Domain (NCBI)PANK1
PDB (RSDB)2I7N    3SMP   
PDB Europe2I7N    3SMP   
PDB (PDBSum)2I7N    3SMP   
PDB (IMB)2I7N    3SMP   
Structural Biology KnowledgeBase2I7N    3SMP   
SCOP (Structural Classification of Proteins)2I7N    3SMP   
CATH (Classification of proteins structures)2I7N    3SMP   
SuperfamilyQ8TE04
AlphaFold pdb e-kbQ8TE04   
Human Protein Atlas [tissue]ENSG00000152782-PANK1 [tissue]
HPRD07549
Protein Interaction databases
DIP (DOE-UCLA)Q8TE04
IntAct (EBI)Q8TE04
BioGRIDPANK1
STRING (EMBL)PANK1
ZODIACPANK1
Ontologies - Pathways
QuickGOQ8TE04
Ontology : AmiGOpantothenate kinase activity  pantothenate kinase activity  ATP binding  nucleus  cytoplasm  cytosol  cytosol  coenzyme A biosynthetic process  coenzyme A biosynthetic process  coenzyme A biosynthetic process  phosphorylation  protein homodimerization activity  acetyl-CoA binding  
Ontology : EGO-EBIpantothenate kinase activity  pantothenate kinase activity  ATP binding  nucleus  cytoplasm  cytosol  cytosol  coenzyme A biosynthetic process  coenzyme A biosynthetic process  coenzyme A biosynthetic process  phosphorylation  protein homodimerization activity  acetyl-CoA binding  
Pathways : KEGGPantothenate and CoA biosynthesis   
NDEx NetworkPANK1
Atlas of Cancer Signalling NetworkPANK1
Wikipedia pathwaysPANK1
Orthology - Evolution
OrthoDB53354
GeneTree (enSembl)ENSG00000152782
Phylogenetic Trees/Animal Genes : TreeFamPANK1
Homologs : HomoloGenePANK1
Homology/Alignments : Family Browser (UCSC)PANK1
Gene fusions - Rearrangements
Fusion : QuiverPANK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPANK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PANK1
dbVarPANK1
ClinVarPANK1
MonarchPANK1
1000_GenomesPANK1 
Exome Variant ServerPANK1
GNOMAD BrowserENSG00000152782
Varsome BrowserPANK1
ACMGPANK1 variants
VarityQ8TE04
Genomic Variants (DGV)PANK1 [DGVbeta]
DECIPHERPANK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPANK1 
Mutations
ICGC Data PortalPANK1 
TCGA Data PortalPANK1 
Broad Tumor PortalPANK1
OASIS PortalPANK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPANK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPANK1
Mutations and Diseases : HGMDPANK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPANK1
DgiDB (Drug Gene Interaction Database)PANK1
DoCM (Curated mutations)PANK1
CIViC (Clinical Interpretations of Variants in Cancer)PANK1
Cancer3DPANK1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606160   
Orphanet
DisGeNETPANK1
MedgenPANK1
Genetic Testing Registry PANK1
NextProtQ8TE04 [Medical]
GENETestsPANK1
Target ValidationPANK1
Huge Navigator PANK1 [HugePedia]
ClinGenPANK1
Clinical trials, drugs, therapy
MyCancerGenomePANK1
Protein Interactions : CTDPANK1
Pharm GKB GenePA32928
PharosQ8TE04
Clinical trialPANK1
Miscellaneous
canSAR (ICR)PANK1
HarmonizomePANK1
DataMed IndexPANK1
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPANK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:15:24 CEST 2021

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