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PANK1 (pantothenate kinase 1)

Identity

Alias_namesPANK
pantothenate kinase
Alias_symbol (synonym)MGC24596
PANK1a
PANK1b
Other alias
HGNC (Hugo) PANK1
LocusID (NCBI) 53354
Atlas_Id 71647
Location 10q23.31  [Link to chromosome band 10q23]
Location_base_pair Starts at 91339254 and ends at 91403648 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PANK1 (10q23.31) / C8orf34 (8q13.2)PANK1 (10q23.31) / PDK3 (Xp22.11)TRDMT1 (10p13) / PANK1 (10q23.31)
PANK1 C8orf34PANK1 PDK3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PANK1   8598
Cards
Entrez_Gene (NCBI)PANK1  53354  pantothenate kinase 1
AliasesPANK
GeneCards (Weizmann)PANK1
Ensembl hg19 (Hinxton)ENSG00000152782 [Gene_View]  chr10:91339254-91403648 [Contig_View]  PANK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000152782 [Gene_View]  chr10:91339254-91403648 [Contig_View]  PANK1 [Vega]
ICGC DataPortalENSG00000152782
TCGA cBioPortalPANK1
AceView (NCBI)PANK1
Genatlas (Paris)PANK1
WikiGenes53354
SOURCE (Princeton)PANK1
Genetics Home Reference (NIH)PANK1
Genomic and cartography
GoldenPath hg19 (UCSC)PANK1  -     chr10:91339254-91403648 -  10q23.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PANK1  -     10q23.31   [Description]    (hg38-Dec_2013)
EnsemblPANK1 - 10q23.31 [CytoView hg19]  PANK1 - 10q23.31 [CytoView hg38]
Mapping of homologs : NCBIPANK1 [Mapview hg19]  PANK1 [Mapview hg38]
OMIM606160   
Gene and transcription
Genbank (Entrez)AF355198 AK057932 AK125428 AK127777 AY027661
RefSeq transcript (Entrez)NM_138316 NM_148977 NM_148978
RefSeq genomic (Entrez)NC_000010 NC_018921 NG_029474 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)PANK1
Cluster EST : UnigeneHs.163555 [ NCBI ]
CGAP (NCI)Hs.163555
Alternative Splicing GalleryENSG00000152782
Gene ExpressionPANK1 [ NCBI-GEO ]   PANK1 [ EBI - ARRAY_EXPRESS ]   PANK1 [ SEEK ]   PANK1 [ MEM ]
Gene Expression Viewer (FireBrowse)PANK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53354
GTEX Portal (Tissue expression)PANK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TE04   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TE04  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TE04
Splice isoforms : SwissVarQ8TE04
Catalytic activity : Enzyme2.7.1.33 [ Enzyme-Expasy ]   2.7.1.332.7.1.33 [ IntEnz-EBI ]   2.7.1.33 [ BRENDA ]   2.7.1.33 [ KEGG ]   
PhosPhoSitePlusQ8TE04
Domains : Interpro (EBI)Type_II_PanK   
Domain families : Pfam (Sanger)Fumble (PF03630)   
Domain families : Pfam (NCBI)pfam03630   
Conserved Domain (NCBI)PANK1
DMDM Disease mutations53354
Blocks (Seattle)PANK1
PDB (SRS)2I7N    3SMP   
PDB (PDBSum)2I7N    3SMP   
PDB (IMB)2I7N    3SMP   
PDB (RSDB)2I7N    3SMP   
Structural Biology KnowledgeBase2I7N    3SMP   
SCOP (Structural Classification of Proteins)2I7N    3SMP   
CATH (Classification of proteins structures)2I7N    3SMP   
SuperfamilyQ8TE04
Human Protein AtlasENSG00000152782
Peptide AtlasQ8TE04
HPRD07549
IPIIPI00152578   IPI00170950   IPI00220147   IPI00553196   IPI01013927   
Protein Interaction databases
DIP (DOE-UCLA)Q8TE04
IntAct (EBI)Q8TE04
FunCoupENSG00000152782
BioGRIDPANK1
STRING (EMBL)PANK1
ZODIACPANK1
Ontologies - Pathways
QuickGOQ8TE04
Ontology : AmiGOpantothenate kinase activity  ATP binding  nucleus  cytosol  vitamin metabolic process  water-soluble vitamin metabolic process  coenzyme biosynthetic process  coenzyme A biosynthetic process  pantothenate metabolic process  phosphorylation  clathrin coat  small molecule metabolic process  recycling endosome  cell periphery  
Ontology : EGO-EBIpantothenate kinase activity  ATP binding  nucleus  cytosol  vitamin metabolic process  water-soluble vitamin metabolic process  coenzyme biosynthetic process  coenzyme A biosynthetic process  pantothenate metabolic process  phosphorylation  clathrin coat  small molecule metabolic process  recycling endosome  cell periphery  
Pathways : KEGGPantothenate and CoA biosynthesis   
NDEx NetworkPANK1
Atlas of Cancer Signalling NetworkPANK1
Wikipedia pathwaysPANK1
Orthology - Evolution
OrthoDB53354
GeneTree (enSembl)ENSG00000152782
Phylogenetic Trees/Animal Genes : TreeFamPANK1
HOVERGENQ8TE04
HOGENOMQ8TE04
Homologs : HomoloGenePANK1
Homology/Alignments : Family Browser (UCSC)PANK1
Gene fusions - Rearrangements
Fusion: TCGAPANK1 C8orf34
Fusion: TCGAPANK1 PDK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPANK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PANK1
dbVarPANK1
ClinVarPANK1
1000_GenomesPANK1 
Exome Variant ServerPANK1
ExAC (Exome Aggregation Consortium)PANK1 (select the gene name)
Genetic variants : HAPMAP53354
Genomic Variants (DGV)PANK1 [DGVbeta]
DECIPHER (Syndromes)10:91339254-91403648  ENSG00000152782
CONAN: Copy Number AnalysisPANK1 
Mutations
ICGC Data PortalPANK1 
TCGA Data PortalPANK1 
Broad Tumor PortalPANK1
OASIS PortalPANK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPANK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPANK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PANK1
DgiDB (Drug Gene Interaction Database)PANK1
DoCM (Curated mutations)PANK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PANK1 (select a term)
intoGenPANK1
Cancer3DPANK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606160   
Orphanet
MedgenPANK1
Genetic Testing Registry PANK1
NextProtQ8TE04 [Medical]
TSGene53354
GENETestsPANK1
Huge Navigator PANK1 [HugePedia]
snp3D : Map Gene to Disease53354
BioCentury BCIQPANK1
ClinGenPANK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD53354
Chemical/Pharm GKB GenePA32928
Clinical trialPANK1
Miscellaneous
canSAR (ICR)PANK1 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePANK1
EVEXPANK1
GoPubMedPANK1
iHOPPANK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:37:44 CET 2017

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