PANK4 (pantothenate kinase 4 (inactive))

2014-11-01  

Identity

HGNC
PANK4
LOCATION
1p36.32
LOCUSID
55229
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55229
MIM: 606162
HGNC: 19366
Ensembl: ENSG00000157881

Variants:

dbSNP: 55229
ClinVar: 55229
TCGA: ENSG00000157881
COSMIC: PANK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157881ENST00000378466Q9NVE7
ENSG00000157881ENST00000435556E9PHT6
ENSG00000157881ENST00000468002H0YA31
ENSG00000157881ENST00000486396H0YA02
ENSG00000157881ENST00000502512H0Y9E4
ENSG00000157881ENST00000502770D6RJF3
ENSG00000157881ENST00000505228H0YA26

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pantothenate and CoA biosynthesisKEGGko00770
Pantothenate and CoA biosynthesisKEGGhsa00770
Metabolic pathwaysKEGGhsa01100
Coenzyme A biosynthesis, pantothenate => CoAKEGGhsa_M00120
Coenzyme A biosynthesis, pantothenate => CoAKEGGM00120
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin B5 (pantothenate) metabolismREACTOMER-HSA-199220
Coenzyme A biosynthesisREACTOMER-HSA-196783

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
161327222005High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2).11
309273262019Human pantothenate kinase 4 is a pseudo-pantothenate kinase.3
160382592005[Screening susceptibility genes of type 2 diabetes in Chinese population by single nucleotide polymorphism analysis].1
305853702019A novel mutation of PANK4 causes autosomal dominant congenital posterior cataract.1

Citation

Dessen P

PANK4 (pantothenate kinase 4 (inactive))

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71650/pank4