PANX1 (pannexin 1)

2011-02-01  

Identity

HGNC
PANX1
LOCATION
11q21
LOCUSID
24145
ALIAS
MRS1,OOMD7,PX1,UNQ2529
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 24145
MIM: 608420
HGNC: 8599
Ensembl: ENSG00000110218

Variants:

dbSNP: 24145
ClinVar: 24145
TCGA: ENSG00000110218
COSMIC: PANX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110218ENST00000227638Q96RD7
ENSG00000110218ENST00000227638A0A024R397
ENSG00000110218ENST00000436171Q96RD7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Neuronal SystemREACTOMER-HSA-112316
Transmission across Electrical SynapsesREACTOMER-HSA-112307
Electric Transmission Across Gap JunctionsREACTOMER-HSA-112303
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACTOMER-HSA-168643
InflammasomesREACTOMER-HSA-622312
The NLRP3 inflammasomeREACTOMER-HSA-844456

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
170360482006Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor.495
170360482006Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor.495
209447492010Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis.351
166826482006Pannexin 1 in erythrocytes: function without a gap.218
166908682006Ischemia opens neuronal gap junction hemichannels.186
172403702007Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex.171
179253792007Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins.165
190569882008Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus.153
185962112008P2X7 receptor-Pannexin1 complex: pharmacology and signaling.144
177151322007Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane.122

Citation

Dessen P

PANX1 (pannexin 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52073/panx1