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PANX1 (pannexin 1)

Identity

Alias_symbol (synonym)MRS1
UNQ2529
PX1
Other alias
HGNC (Hugo) PANX1
LocusID (NCBI) 24145
Atlas_Id 52073
Location 11q21  [Link to chromosome band 11q21]
Location_base_pair Starts at 93862094 and ends at 93915137 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HEPHL1 (11q21) / PANX1 (11q21)PANX1 (11q21) / CCDC67 (11q21)PANX1 (11q21) / CEP126 (11q22.1)
PANX1 (11q21) / HEPHL1 (11q21)PANX1 (11q21) / PANX1 (11q21)PANX1 11q21 / CCDC67 11q21
PANX1 11q21 / HEPHL1 11q21PANX1 11q21 KIAA1377

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PANX1   8599
Cards
Entrez_Gene (NCBI)PANX1  24145  pannexin 1
AliasesMRS1; PX1; UNQ2529
GeneCards (Weizmann)PANX1
Ensembl hg19 (Hinxton)ENSG00000110218 [Gene_View]  chr11:93862094-93915137 [Contig_View]  PANX1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000110218 [Gene_View]  chr11:93862094-93915137 [Contig_View]  PANX1 [Vega]
ICGC DataPortalENSG00000110218
TCGA cBioPortalPANX1
AceView (NCBI)PANX1
Genatlas (Paris)PANX1
WikiGenes24145
SOURCE (Princeton)PANX1
Genetics Home Reference (NIH)PANX1
Genomic and cartography
GoldenPath hg19 (UCSC)PANX1  -     chr11:93862094-93915137 +  11q21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PANX1  -     11q21   [Description]    (hg38-Dec_2013)
EnsemblPANX1 - 11q21 [CytoView hg19]  PANX1 - 11q21 [CytoView hg38]
Mapping of homologs : NCBIPANX1 [Mapview hg19]  PANX1 [Mapview hg38]
OMIM608420   
Gene and transcription
Genbank (Entrez)AF398509 AK074897 AK313074 AY359023 BC016931
RefSeq transcript (Entrez)NM_015368
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_027936 NT_033899 NW_004929380
Consensus coding sequences : CCDS (NCBI)PANX1
Cluster EST : UnigeneHs.591976 [ NCBI ]
CGAP (NCI)Hs.591976
Alternative Splicing GalleryENSG00000110218
Gene ExpressionPANX1 [ NCBI-GEO ]   PANX1 [ EBI - ARRAY_EXPRESS ]   PANX1 [ SEEK ]   PANX1 [ MEM ]
Gene Expression Viewer (FireBrowse)PANX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)24145
GTEX Portal (Tissue expression)PANX1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RD7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RD7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RD7
Splice isoforms : SwissVarQ96RD7
PhosPhoSitePlusQ96RD7
Domaine pattern : Prosite (Expaxy)PANNEXIN (PS51013)   
Domains : Interpro (EBI)Innexin   
Domain families : Pfam (Sanger)Innexin (PF00876)   
Domain families : Pfam (NCBI)pfam00876   
Conserved Domain (NCBI)PANX1
DMDM Disease mutations24145
Blocks (Seattle)PANX1
SuperfamilyQ96RD7
Human Protein AtlasENSG00000110218
Peptide AtlasQ96RD7
HPRD10526
IPIIPI00455165   IPI00455166   
Protein Interaction databases
DIP (DOE-UCLA)Q96RD7
IntAct (EBI)Q96RD7
FunCoupENSG00000110218
BioGRIDPANX1
STRING (EMBL)PANX1
ZODIACPANX1
Ontologies - Pathways
QuickGOQ96RD7
Ontology : AmiGOprotease binding  response to ischemia  receptor binding  calcium channel activity  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  gap junction  cation transport  calcium ion transport  cell-cell signaling  membrane  integral component of membrane  leak channel activity  bleb  response to ATP  protein hexamerization  protein complex  ion channel binding  protein heterodimerization activity  positive regulation of interleukin-1 alpha secretion  positive regulation of interleukin-1 beta secretion  actin filament binding  gap junction hemi-channel activity  calcium ion transmembrane transport  scaffold protein binding  
Ontology : EGO-EBIprotease binding  response to ischemia  receptor binding  calcium channel activity  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  gap junction  cation transport  calcium ion transport  cell-cell signaling  membrane  integral component of membrane  leak channel activity  bleb  response to ATP  protein hexamerization  protein complex  ion channel binding  protein heterodimerization activity  positive regulation of interleukin-1 alpha secretion  positive regulation of interleukin-1 beta secretion  actin filament binding  gap junction hemi-channel activity  calcium ion transmembrane transport  scaffold protein binding  
NDEx NetworkPANX1
Atlas of Cancer Signalling NetworkPANX1
Wikipedia pathwaysPANX1
Orthology - Evolution
OrthoDB24145
GeneTree (enSembl)ENSG00000110218
Phylogenetic Trees/Animal Genes : TreeFamPANX1
HOVERGENQ96RD7
HOGENOMQ96RD7
Homologs : HomoloGenePANX1
Homology/Alignments : Family Browser (UCSC)PANX1
Gene fusions - Rearrangements
Fusion : MitelmanPANX1/CEP126 [11q21/11q22.1]  
Fusion: TCGAPANX1 11q21 CCDC67 11q21 LUSC
Fusion: TCGAPANX1 11q21 HEPHL1 11q21 HNSC
Fusion: TCGAPANX1 11q21 KIAA1377 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPANX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PANX1
dbVarPANX1
ClinVarPANX1
1000_GenomesPANX1 
Exome Variant ServerPANX1
ExAC (Exome Aggregation Consortium)PANX1 (select the gene name)
Genetic variants : HAPMAP24145
Genomic Variants (DGV)PANX1 [DGVbeta]
DECIPHER (Syndromes)11:93862094-93915137  ENSG00000110218
CONAN: Copy Number AnalysisPANX1 
Mutations
ICGC Data PortalPANX1 
TCGA Data PortalPANX1 
Broad Tumor PortalPANX1
OASIS PortalPANX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPANX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPANX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PANX1
DgiDB (Drug Gene Interaction Database)PANX1
DoCM (Curated mutations)PANX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PANX1 (select a term)
intoGenPANX1
Cancer3DPANX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608420   
Orphanet
MedgenPANX1
Genetic Testing Registry PANX1
NextProtQ96RD7 [Medical]
TSGene24145
GENETestsPANX1
Huge Navigator PANX1 [HugePedia]
snp3D : Map Gene to Disease24145
BioCentury BCIQPANX1
ClinGenPANX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD24145
Chemical/Pharm GKB GenePA32929
Clinical trialPANX1
Miscellaneous
canSAR (ICR)PANX1 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePANX1
EVEXPANX1
GoPubMedPANX1
iHOPPANX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:13:29 CEST 2017

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