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PANX1 (pannexin 1)

Identity

Alias (NCBI)MRS1
OOMD7
PX1
UNQ2529
HGNC (Hugo) PANX1
HGNC Alias symbMRS1
UNQ2529
PX1
HGNC Alias nameinnexin
LocusID (NCBI) 24145
Atlas_Id 52073
Location 11q21  [Link to chromosome band 11q21]
Location_base_pair Starts at 94128841 and ends at 94181968 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HEPHL1 (11q21) / PANX1 (11q21)PANX1 (11q21) / CCDC67 (11q21)PANX1 (11q21) / CEP126 (11q22.1)
PANX1 (11q21) / HEPHL1 (11q21)PANX1 (11q21) / PANX1 (11q21)PANX1 11q21 / CCDC67 11q21
PANX1 11q21 / HEPHL1 11q21PANX1 11q21 KIAA1377

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PANX1   8599
Cards
Entrez_Gene (NCBI)PANX1    pannexin 1
AliasesMRS1; OOMD7; PX1; UNQ2529
GeneCards (Weizmann)PANX1
Ensembl hg19 (Hinxton)ENSG00000110218 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110218 [Gene_View]  ENSG00000110218 [Sequence]  chr11:94128841-94181968 [Contig_View]  PANX1 [Vega]
ICGC DataPortalENSG00000110218
TCGA cBioPortalPANX1
AceView (NCBI)PANX1
Genatlas (Paris)PANX1
SOURCE (Princeton)PANX1
Genetics Home Reference (NIH)PANX1
Genomic and cartography
GoldenPath hg38 (UCSC)PANX1  -     chr11:94128841-94181968 +  11q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PANX1  -     11q21   [Description]    (hg19-Feb_2009)
GoldenPathPANX1 - 11q21 [CytoView hg19]  PANX1 - 11q21 [CytoView hg38]
ImmunoBaseENSG00000110218
Genome Data Viewer NCBIPANX1 [Mapview hg19]  
OMIM608420   618550   
Gene and transcription
Genbank (Entrez)AF398509 AK074897 AK313074 AY359023 BC016931
RefSeq transcript (Entrez)NM_015368
Consensus coding sequences : CCDS (NCBI)PANX1
Gene ExpressionPANX1 [ NCBI-GEO ]   PANX1 [ EBI - ARRAY_EXPRESS ]   PANX1 [ SEEK ]   PANX1 [ MEM ]
Gene Expression Viewer (FireBrowse)PANX1 [ Firebrowse - Broad ]
GenevisibleExpression of PANX1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)24145
GTEX Portal (Tissue expression)PANX1
Human Protein AtlasENSG00000110218-PANX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RD7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RD7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RD7
PhosPhoSitePlusQ96RD7
Domaine pattern : Prosite (Expaxy)PANNEXIN (PS51013)   
Domains : Interpro (EBI)Innexin    Pannexin   
Domain families : Pfam (Sanger)Innexin (PF00876)   
Domain families : Pfam (NCBI)pfam00876   
Conserved Domain (NCBI)PANX1
PDB (RSDB)6LTN    6LTO    6M02    6M66    6M67    6M68    6V6D    6WBF    6WBG    6WBI    6WBK    6WBL    6WBM    6WBN   
PDB Europe6LTN    6LTO    6M02    6M66    6M67    6M68    6V6D    6WBF    6WBG    6WBI    6WBK    6WBL    6WBM    6WBN   
PDB (PDBSum)6LTN    6LTO    6M02    6M66    6M67    6M68    6V6D    6WBF    6WBG    6WBI    6WBK    6WBL    6WBM    6WBN   
PDB (IMB)6LTN    6LTO    6M02    6M66    6M67    6M68    6V6D    6WBF    6WBG    6WBI    6WBK    6WBL    6WBM    6WBN   
Structural Biology KnowledgeBase6LTN    6LTO    6M02    6M66    6M67    6M68    6V6D    6WBF    6WBG    6WBI    6WBK    6WBL    6WBM    6WBN   
SCOP (Structural Classification of Proteins)6LTN    6LTO    6M02    6M66    6M67    6M68    6V6D    6WBF    6WBG    6WBI    6WBK    6WBL    6WBM    6WBN   
CATH (Classification of proteins structures)6LTN    6LTO    6M02    6M66    6M67    6M68    6V6D    6WBF    6WBG    6WBI    6WBK    6WBL    6WBM    6WBN   
SuperfamilyQ96RD7
AlphaFold pdb e-kbQ96RD7   
Human Protein Atlas [tissue]ENSG00000110218-PANX1 [tissue]
HPRD10526
Protein Interaction databases
DIP (DOE-UCLA)Q96RD7
IntAct (EBI)Q96RD7
BioGRIDPANX1
STRING (EMBL)PANX1
ZODIACPANX1
Ontologies - Pathways
QuickGOQ96RD7
Ontology : AmiGOprotease binding  response to ischemia  signaling receptor binding  structural molecule activity  calcium channel activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  plasma membrane  gap junction  cation transport  cation transport  calcium ion transport  cell-cell signaling  membrane  integral component of membrane  wide pore channel activity  leak channel activity  bleb  positive regulation of interleukin-1 alpha production  positive regulation of interleukin-1 beta production  protein-containing complex  response to ATP  ion channel binding  oogenesis  actin filament binding  gap junction hemi-channel activity  calcium ion transmembrane transport  scaffold protein binding  
Ontology : EGO-EBIprotease binding  response to ischemia  signaling receptor binding  structural molecule activity  calcium channel activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  plasma membrane  gap junction  cation transport  cation transport  calcium ion transport  cell-cell signaling  membrane  integral component of membrane  wide pore channel activity  leak channel activity  bleb  positive regulation of interleukin-1 alpha production  positive regulation of interleukin-1 beta production  protein-containing complex  response to ATP  ion channel binding  oogenesis  actin filament binding  gap junction hemi-channel activity  calcium ion transmembrane transport  scaffold protein binding  
NDEx NetworkPANX1
Atlas of Cancer Signalling NetworkPANX1
Wikipedia pathwaysPANX1
Orthology - Evolution
OrthoDB24145
GeneTree (enSembl)ENSG00000110218
Phylogenetic Trees/Animal Genes : TreeFamPANX1
Homologs : HomoloGenePANX1
Homology/Alignments : Family Browser (UCSC)PANX1
Gene fusions - Rearrangements
Fusion : MitelmanPANX1/CEP126 [11q21/11q22.1]  
Fusion : QuiverPANX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPANX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PANX1
dbVarPANX1
ClinVarPANX1
MonarchPANX1
1000_GenomesPANX1 
Exome Variant ServerPANX1
GNOMAD BrowserENSG00000110218
Varsome BrowserPANX1
ACMGPANX1 variants
VarityQ96RD7
Genomic Variants (DGV)PANX1 [DGVbeta]
DECIPHERPANX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPANX1 
Mutations
ICGC Data PortalPANX1 
TCGA Data PortalPANX1 
Broad Tumor PortalPANX1
OASIS PortalPANX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPANX1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPANX1
Mutations and Diseases : HGMDPANX1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPANX1
DgiDB (Drug Gene Interaction Database)PANX1
DoCM (Curated mutations)PANX1
CIViC (Clinical Interpretations of Variants in Cancer)PANX1
Cancer3DPANX1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608420    618550   
Orphanet
DisGeNETPANX1
MedgenPANX1
Genetic Testing Registry PANX1
NextProtQ96RD7 [Medical]
GENETestsPANX1
Target ValidationPANX1
Huge Navigator PANX1 [HugePedia]
ClinGenPANX1
Clinical trials, drugs, therapy
MyCancerGenomePANX1
Protein Interactions : CTDPANX1
Pharm GKB GenePA32929
PharosQ96RD7
Clinical trialPANX1
Miscellaneous
canSAR (ICR)PANX1
HarmonizomePANX1
DataMed IndexPANX1
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPANX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:24:15 CEST 2021

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