PAOX (polyamine oxidase)

2007-02-01  

Identity

HGNC
LOCATION
10q26.3
LOCUSID
ALIAS
PAO
FUSION GENES

Other Information

Locus ID:

NCBI: 196743
MIM: 615853
HGNC: 20837
Ensembl: ENSG00000148832

Variants:

dbSNP: 196743
ClinVar: 196743
TCGA: ENSG00000148832
COSMIC: PAOX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148832ENST00000278060Q6QHF9
ENSG00000148832ENST00000356306Q6QHF9
ENSG00000148832ENST00000357296Q6QHF9
ENSG00000148832ENST00000476834Q6QHF9
ENSG00000148832ENST00000480071Q6QHF9
ENSG00000148832ENST00000483211Q6QHF9
ENSG00000148832ENST00000529585Q6QHF9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Interconversion of polyaminesREACTOMER-HSA-351200
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Amine Oxidase reactionsREACTOMER-HSA-140179
PAOs oxidise polyamines to aminesREACTOMER-HSA-141334

References

Pubmed IDYearTitleCitations
162077102005Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.43
163546692006Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase.4
204053122010Does polyamine oxidase activity influence the oxidative metabolism of children who suffer of diabetes mellitus?3
265475062016Integrative analysis of copy number and gene expression data suggests novel pathogenetic mechanisms in primary myelofibrosis.2

Citation

Dessen P

PAOX (polyamine oxidase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46509/paox