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PAPOLA (poly(A) polymerase alpha)

Identity

Alias_symbol (synonym)PAP
Other alias
HGNC (Hugo) PAPOLA
LocusID (NCBI) 10914
Atlas_Id 54526
Location 14q32.2  [Link to chromosome band 14q32]
Location_base_pair Starts at 96968713 and ends at 97001935 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANGEL2 (1q32.3) / PAPOLA (14q32.2)PAPOLA (14q32.2) / AK7 (14q32.2)PAPOLA (14q32.2) / COL6A2 (21q22.3)
PAPOLA (14q32.2) / GALNT5 (2q24.1)PAPOLA (14q32.2) / HIP1R (12q24.31)PAPOLA (14q32.2) / SORT1 (1p13.3)
PAPOLA 14q32.2 / AK7 14q32.2PAPOLA 14q32.2 / GALNT5 2q24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PAPOLA   14981
Cards
Entrez_Gene (NCBI)PAPOLA  10914  poly(A) polymerase alpha
AliasesPAP
GeneCards (Weizmann)PAPOLA
Ensembl hg19 (Hinxton)ENSG00000090060 [Gene_View]  chr14:96968713-97001935 [Contig_View]  PAPOLA [Vega]
Ensembl hg38 (Hinxton)ENSG00000090060 [Gene_View]  chr14:96968713-97001935 [Contig_View]  PAPOLA [Vega]
ICGC DataPortalENSG00000090060
TCGA cBioPortalPAPOLA
AceView (NCBI)PAPOLA
Genatlas (Paris)PAPOLA
WikiGenes10914
SOURCE (Princeton)PAPOLA
Genetics Home Reference (NIH)PAPOLA
Genomic and cartography
GoldenPath hg19 (UCSC)PAPOLA  -     chr14:96968713-97001935 +  14q32.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PAPOLA  -     14q32.2   [Description]    (hg38-Dec_2013)
EnsemblPAPOLA - 14q32.2 [CytoView hg19]  PAPOLA - 14q32.2 [CytoView hg38]
Mapping of homologs : NCBIPAPOLA [Mapview hg19]  PAPOLA [Mapview hg38]
OMIM605553   
Gene and transcription
Genbank (Entrez)AA236200 AF002990 AK024849 AK057629 AK097832
RefSeq transcript (Entrez)NM_001252006 NM_001252007 NM_001293627 NM_001293628 NM_001293632 NM_032632
RefSeq genomic (Entrez)NC_000014 NC_018925 NG_030439 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)PAPOLA
Cluster EST : UnigeneHs.253726 [ NCBI ]
CGAP (NCI)Hs.253726
Alternative Splicing GalleryENSG00000090060
Gene ExpressionPAPOLA [ NCBI-GEO ]   PAPOLA [ EBI - ARRAY_EXPRESS ]   PAPOLA [ SEEK ]   PAPOLA [ MEM ]
Gene Expression Viewer (FireBrowse)PAPOLA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10914
GTEX Portal (Tissue expression)PAPOLA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51003   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51003  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51003
Splice isoforms : SwissVarP51003
Catalytic activity : Enzyme2.7.7.19 [ Enzyme-Expasy ]   2.7.7.192.7.7.19 [ IntEnz-EBI ]   2.7.7.19 [ BRENDA ]   2.7.7.19 [ KEGG ]   
PhosPhoSitePlusP51003
Domains : Interpro (EBI)NuclTrfase_I_C    PolA_pol_cen_dom    PolA_pol_RNA-bd_dom    PolyA_polymerase    Polymerase_NTP_transf_dom   
Domain families : Pfam (Sanger)NTP_transf_2 (PF01909)    PAP_central (PF04928)    PAP_RNA-bind (PF04926)   
Domain families : Pfam (NCBI)pfam01909    pfam04928    pfam04926   
Conserved Domain (NCBI)PAPOLA
DMDM Disease mutations10914
Blocks (Seattle)PAPOLA
SuperfamilyP51003
Human Protein AtlasENSG00000090060
Peptide AtlasP51003
HPRD10407
IPIIPI01025082   IPI00384028   IPI01018609   IPI00872966   IPI01024993   IPI01025363   IPI01025243   IPI01025607   IPI01025472   IPI01025830   IPI01025749   
Protein Interaction databases
DIP (DOE-UCLA)P51003
IntAct (EBI)P51003
FunCoupENSG00000090060
BioGRIDPAPOLA
STRING (EMBL)PAPOLA
ZODIACPAPOLA
Ontologies - Pathways
QuickGOP51003
Ontology : AmiGOmagnesium ion binding  mRNA splicing, via spliceosome  RNA binding  polynucleotide adenylyltransferase activity  polynucleotide adenylyltransferase activity  polynucleotide adenylyltransferase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  termination of RNA polymerase II transcription  mRNA polyadenylation  manganese ion binding  mRNA 3'-end processing  regulation of mRNA 3'-end processing  RNA polyadenylation  
Ontology : EGO-EBImagnesium ion binding  mRNA splicing, via spliceosome  RNA binding  polynucleotide adenylyltransferase activity  polynucleotide adenylyltransferase activity  polynucleotide adenylyltransferase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  termination of RNA polymerase II transcription  mRNA polyadenylation  manganese ion binding  mRNA 3'-end processing  regulation of mRNA 3'-end processing  RNA polyadenylation  
Pathways : BIOCARTAPolyadenylation of mRNA [Genes]   
Pathways : KEGGmRNA surveillance pathway   
NDEx NetworkPAPOLA
Atlas of Cancer Signalling NetworkPAPOLA
Wikipedia pathwaysPAPOLA
Orthology - Evolution
OrthoDB10914
GeneTree (enSembl)ENSG00000090060
Phylogenetic Trees/Animal Genes : TreeFamPAPOLA
HOVERGENP51003
HOGENOMP51003
Homologs : HomoloGenePAPOLA
Homology/Alignments : Family Browser (UCSC)PAPOLA
Gene fusions - Rearrangements
Fusion : MitelmanPAPOLA/AK7 [14q32.2/14q32.2]  
Fusion : MitelmanPAPOLA/GALNT5 [14q32.2/2q24.1]  [t(2;14)(q24;q32)]  
Fusion : MitelmanPAPOLA/HIP1R [14q32.2/12q24.31]  [t(12;14)(q24;q32)]  
Fusion: TCGAPAPOLA 14q32.2 AK7 14q32.2 LUAD
Fusion: TCGAPAPOLA 14q32.2 GALNT5 2q24.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPAPOLA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PAPOLA
dbVarPAPOLA
ClinVarPAPOLA
1000_GenomesPAPOLA 
Exome Variant ServerPAPOLA
ExAC (Exome Aggregation Consortium)PAPOLA (select the gene name)
Genetic variants : HAPMAP10914
Genomic Variants (DGV)PAPOLA [DGVbeta]
DECIPHER (Syndromes)14:96968713-97001935  ENSG00000090060
CONAN: Copy Number AnalysisPAPOLA 
Mutations
ICGC Data PortalPAPOLA 
TCGA Data PortalPAPOLA 
Broad Tumor PortalPAPOLA
OASIS PortalPAPOLA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPAPOLA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPAPOLA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PAPOLA
DgiDB (Drug Gene Interaction Database)PAPOLA
DoCM (Curated mutations)PAPOLA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PAPOLA (select a term)
intoGenPAPOLA
Cancer3DPAPOLA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605553   
Orphanet
MedgenPAPOLA
Genetic Testing Registry PAPOLA
NextProtP51003 [Medical]
TSGene10914
GENETestsPAPOLA
Huge Navigator PAPOLA [HugePedia]
snp3D : Map Gene to Disease10914
BioCentury BCIQPAPOLA
ClinGenPAPOLA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10914
Chemical/Pharm GKB GenePA32932
Clinical trialPAPOLA
Miscellaneous
canSAR (ICR)PAPOLA (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePAPOLA
EVEXPAPOLA
GoPubMedPAPOLA
iHOPPAPOLA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:20:21 CET 2017

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