PAPOLA (poly(A) polymerase alpha)

2014-08-01  

Identity

HGNC
LOCATION
14q32.2
LOCUSID
ALIAS
PAP,PAP-alpha
FUSION GENES

Other Information

Locus ID:

NCBI: 10914
MIM: 605553
HGNC: 14981
Ensembl: ENSG00000090060

Variants:

dbSNP: 10914
ClinVar: 10914
TCGA: ENSG00000090060
COSMIC: PAPOLA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090060ENST00000216277P51003
ENSG00000090060ENST00000216277A0A024R6M3
ENSG00000090060ENST00000392990G3XAH6
ENSG00000090060ENST00000553461H0YJ00
ENSG00000090060ENST00000553689G3V457
ENSG00000090060ENST00000556459H0YJL4
ENSG00000090060ENST00000556619G3V3I9
ENSG00000090060ENST00000557320P51003
ENSG00000090060ENST00000557471A0A0C4DGK1

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Processing of Capped Intronless Pre-mRNAREACTOMER-HSA-75067
Processing of Intronless Pre-mRNAsREACTOMER-HSA-77595

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
258969132015Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs.12
264969452016CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding PAPα.8
280965192017The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation.6
201749642010The structure of the 5'-untranslated region of mammalian poly(A) polymerase-alpha mRNA suggests a mechanism of translational regulation.3

Citation

Dessen P

PAPOLA (poly(A) polymerase alpha)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54526/papola