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PAPPA2 (pappalysin 2)

Identity

Alias_namesPLAC3
placenta-specific 3
Alias_symbol (synonym)PAPPE
PAPP-A2
Other aliasPAPP-E
HGNC (Hugo) PAPPA2
LocusID (NCBI) 60676
Atlas_Id 71656
Location 1q25.2  [Link to chromosome band 1q25]
Location_base_pair Starts at 176432307 and ends at 176811970 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADAM12 (10q26.2) / PAPPA2 (1q25.2)DNMBP (10q24.2) / PAPPA2 (1q25.2)PCK1 (20q13.31) / PAPPA2 (1q25.2)
TNS3 (7p12.3) / PAPPA2 (1q25.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PAPPA2   14615
Cards
Entrez_Gene (NCBI)PAPPA2  60676  pappalysin 2
AliasesPAPP-A2; PAPP-E; PAPPE; PLAC3
GeneCards (Weizmann)PAPPA2
Ensembl hg19 (Hinxton)ENSG00000116183 [Gene_View]  chr1:176432307-176811970 [Contig_View]  PAPPA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000116183 [Gene_View]  chr1:176432307-176811970 [Contig_View]  PAPPA2 [Vega]
ICGC DataPortalENSG00000116183
TCGA cBioPortalPAPPA2
AceView (NCBI)PAPPA2
Genatlas (Paris)PAPPA2
WikiGenes60676
SOURCE (Princeton)PAPPA2
Genetics Home Reference (NIH)PAPPA2
Genomic and cartography
GoldenPath hg19 (UCSC)PAPPA2  -     chr1:176432307-176811970 +  1q25.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PAPPA2  -     1q25.2   [Description]    (hg38-Dec_2013)
EnsemblPAPPA2 - 1q25.2 [CytoView hg19]  PAPPA2 - 1q25.2 [CytoView hg38]
Mapping of homologs : NCBIPAPPA2 [Mapview hg19]  PAPPA2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB209369 AF311940 AF342989 AF342990 AJ278348
RefSeq transcript (Entrez)NM_020318 NM_021936
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_023390 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)PAPPA2
Cluster EST : UnigeneHs.187284 [ NCBI ]
CGAP (NCI)Hs.187284
Alternative Splicing GalleryENSG00000116183
Gene ExpressionPAPPA2 [ NCBI-GEO ]   PAPPA2 [ EBI - ARRAY_EXPRESS ]   PAPPA2 [ SEEK ]   PAPPA2 [ MEM ]
Gene Expression Viewer (FireBrowse)PAPPA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)60676
GTEX Portal (Tissue expression)PAPPA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BXP8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BXP8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BXP8
Splice isoforms : SwissVarQ9BXP8
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ9BXP8
Domaine pattern : Prosite (Expaxy)SUSHI (PS50923)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ConA-like_dom    FN3_dom    Myxo_disulph_rpt    Notch_dom    PAPPA2    Peptidase_M43    Sushi_SCR_CCP_dom   
Domain families : Pfam (Sanger)Notch (PF00066)    Peptidase_M43 (PF05572)    Sushi (PF00084)   
Domain families : Pfam (NCBI)pfam00066    pfam05572    pfam00084   
Domain families : Smart (EMBL)CCP (SM00032)  FN3 (SM00060)  NL (SM00004)  
Conserved Domain (NCBI)PAPPA2
DMDM Disease mutations60676
Blocks (Seattle)PAPPA2
SuperfamilyQ9BXP8
Human Protein AtlasENSG00000116183
Peptide AtlasQ9BXP8
HPRD10156
IPIIPI00013569   IPI00171951   
Protein Interaction databases
DIP (DOE-UCLA)Q9BXP8
IntAct (EBI)Q9BXP8
FunCoupENSG00000116183
BioGRIDPAPPA2
STRING (EMBL)PAPPA2
ZODIACPAPPA2
Ontologies - Pathways
QuickGOQ9BXP8
Ontology : AmiGOregulation of cell growth  extracellular region  intracellular  proteolysis  metallopeptidase activity  zinc ion binding  membrane  cell differentiation  cellular protein metabolic process  bone morphogenesis  extracellular exosome  
Ontology : EGO-EBIregulation of cell growth  extracellular region  intracellular  proteolysis  metallopeptidase activity  zinc ion binding  membrane  cell differentiation  cellular protein metabolic process  bone morphogenesis  extracellular exosome  
NDEx NetworkPAPPA2
Atlas of Cancer Signalling NetworkPAPPA2
Wikipedia pathwaysPAPPA2
Orthology - Evolution
OrthoDB60676
GeneTree (enSembl)ENSG00000116183
Phylogenetic Trees/Animal Genes : TreeFamPAPPA2
HOVERGENQ9BXP8
HOGENOMQ9BXP8
Homologs : HomoloGenePAPPA2
Homology/Alignments : Family Browser (UCSC)PAPPA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPAPPA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PAPPA2
dbVarPAPPA2
ClinVarPAPPA2
1000_GenomesPAPPA2 
Exome Variant ServerPAPPA2
ExAC (Exome Aggregation Consortium)PAPPA2 (select the gene name)
Genetic variants : HAPMAP60676
Genomic Variants (DGV)PAPPA2 [DGVbeta]
DECIPHER (Syndromes)1:176432307-176811970  ENSG00000116183
CONAN: Copy Number AnalysisPAPPA2 
Mutations
ICGC Data PortalPAPPA2 
TCGA Data PortalPAPPA2 
Broad Tumor PortalPAPPA2
OASIS PortalPAPPA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPAPPA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPAPPA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PAPPA2
DgiDB (Drug Gene Interaction Database)PAPPA2
DoCM (Curated mutations)PAPPA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PAPPA2 (select a term)
intoGenPAPPA2
Cancer3DPAPPA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPAPPA2
Genetic Testing Registry PAPPA2
NextProtQ9BXP8 [Medical]
TSGene60676
GENETestsPAPPA2
Huge Navigator PAPPA2 [HugePedia]
snp3D : Map Gene to Disease60676
BioCentury BCIQPAPPA2
ClinGenPAPPA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD60676
Chemical/Pharm GKB GenePA33373
Clinical trialPAPPA2
Miscellaneous
canSAR (ICR)PAPPA2 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePAPPA2
EVEXPAPPA2
GoPubMedPAPPA2
iHOPPAPPA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:37:46 CET 2017

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