Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2)

Identity

Alias_symbol (synonym)ATPSK2
Other aliasBCYM4
SK2
HGNC (Hugo) PAPSS2
LocusID (NCBI) 9060
Atlas_Id 53351
Location 10q23.2  [Link to chromosome band 10q23]
Location_base_pair Starts at 87659719 and ends at 87747705 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EMC2 (8q23.1) / PAPSS2 (10q23.2)PAPSS2 (10q23.2) / ATAD1 (10q23.31)PAPSS2 (10q23.2) / MINPP1 (10q23.2)
PLEKHJ1 (19p13.3) / PAPSS2 (10q23.2)PAPSS2 10q23.2 / ATAD1 10q23.31PAPSS2 10q23.2 / MINPP1 10q23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PAPSS2   8604
Cards
Entrez_Gene (NCBI)PAPSS2  9060  3'-phosphoadenosine 5'-phosphosulfate synthase 2
AliasesATPSK2; BCYM4; SK2
GeneCards (Weizmann)PAPSS2
Ensembl hg19 (Hinxton)ENSG00000198682 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198682 [Gene_View]  chr10:87659719-87747705 [Contig_View]  PAPSS2 [Vega]
ICGC DataPortalENSG00000198682
TCGA cBioPortalPAPSS2
AceView (NCBI)PAPSS2
Genatlas (Paris)PAPSS2
WikiGenes9060
SOURCE (Princeton)PAPSS2
Genetics Home Reference (NIH)PAPSS2
Genomic and cartography
GoldenPath hg38 (UCSC)PAPSS2  -     chr10:87659719-87747705 +  10q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PAPSS2  -     10q23.2   [Description]    (hg19-Feb_2009)
EnsemblPAPSS2 - 10q23.2 [CytoView hg19]  PAPSS2 - 10q23.2 [CytoView hg38]
Mapping of homologs : NCBIPAPSS2 [Mapview hg19]  PAPSS2 [Mapview hg38]
OMIM603005   612847   
Gene and transcription
Genbank (Entrez)AF074331 AF091242 AF150754 AF173365 AF313907
RefSeq transcript (Entrez)NM_001015880 NM_004670
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PAPSS2
Cluster EST : UnigeneHs.524491 [ NCBI ]
CGAP (NCI)Hs.524491
Alternative Splicing GalleryENSG00000198682
Gene ExpressionPAPSS2 [ NCBI-GEO ]   PAPSS2 [ EBI - ARRAY_EXPRESS ]   PAPSS2 [ SEEK ]   PAPSS2 [ MEM ]
Gene Expression Viewer (FireBrowse)PAPSS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9060
GTEX Portal (Tissue expression)PAPSS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95340   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95340  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95340
Splice isoforms : SwissVarO95340
Catalytic activity : Enzyme2.7.7.4 [ Enzyme-Expasy ]   2.7.7.42.7.7.4 [ IntEnz-EBI ]   2.7.7.4 [ BRENDA ]   2.7.7.4 [ KEGG ]   
PhosPhoSitePlusO95340
Domains : Interpro (EBI)APS_kinase    ATP-Sase_PUA-like_dom    P-loop_NTPase    PUA-like_domain    Rossmann-like_a/b/a_fold    Sulfurylase_cat_dom    Sulphate_adenylyltransferase   
Domain families : Pfam (Sanger)ATP-sulfurylase (PF01747)    PUA_2 (PF14306)   
Domain families : Pfam (NCBI)pfam01747    pfam14306   
Conserved Domain (NCBI)PAPSS2
DMDM Disease mutations9060
Blocks (Seattle)PAPSS2
PDB (SRS)2AX4   
PDB (PDBSum)2AX4   
PDB (IMB)2AX4   
PDB (RSDB)2AX4   
Structural Biology KnowledgeBase2AX4   
SCOP (Structural Classification of Proteins)2AX4   
CATH (Classification of proteins structures)2AX4   
SuperfamilyO95340
Human Protein AtlasENSG00000198682
Peptide AtlasO95340
HPRD04303
IPIIPI00030009   IPI00220873   IPI00940970   IPI01018678   
Protein Interaction databases
DIP (DOE-UCLA)O95340
IntAct (EBI)O95340
FunCoupENSG00000198682
BioGRIDPAPSS2
STRING (EMBL)PAPSS2
ZODIACPAPSS2
Ontologies - Pathways
QuickGOO95340
Ontology : AmiGOsulfate assimilation  skeletal system development  adenylylsulfate kinase activity  sulfate adenylyltransferase (ATP) activity  sulfate adenylyltransferase (ATP) activity  ATP binding  cytosol  blood coagulation  phosphorylation  nucleotidyltransferase activity  3'-phosphoadenosine 5'-phosphosulfate biosynthetic process  bone development  
Ontology : EGO-EBIsulfate assimilation  skeletal system development  adenylylsulfate kinase activity  sulfate adenylyltransferase (ATP) activity  sulfate adenylyltransferase (ATP) activity  ATP binding  cytosol  blood coagulation  phosphorylation  nucleotidyltransferase activity  3'-phosphoadenosine 5'-phosphosulfate biosynthetic process  bone development  
Pathways : KEGGPurine metabolism    Selenocompound metabolism    Sulfur metabolism   
NDEx NetworkPAPSS2
Atlas of Cancer Signalling NetworkPAPSS2
Wikipedia pathwaysPAPSS2
Orthology - Evolution
OrthoDB9060
GeneTree (enSembl)ENSG00000198682
Phylogenetic Trees/Animal Genes : TreeFamPAPSS2
HOVERGENO95340
HOGENOMO95340
Homologs : HomoloGenePAPSS2
Homology/Alignments : Family Browser (UCSC)PAPSS2
Gene fusions - Rearrangements
Fusion : MitelmanPAPSS2/ATAD1 [10q23.2/10q23.31]  
Fusion : MitelmanPAPSS2/MINPP1 [10q23.2/10q23.2]  [t(10;10)(q23;q23)]  
Fusion: TCGAPAPSS2 10q23.2 ATAD1 10q23.31 LGG
Fusion: TCGAPAPSS2 10q23.2 MINPP1 10q23.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPAPSS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PAPSS2
dbVarPAPSS2
ClinVarPAPSS2
1000_GenomesPAPSS2 
Exome Variant ServerPAPSS2
ExAC (Exome Aggregation Consortium)PAPSS2 (select the gene name)
Genetic variants : HAPMAP9060
Genomic Variants (DGV)PAPSS2 [DGVbeta]
DECIPHERPAPSS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPAPSS2 
Mutations
ICGC Data PortalPAPSS2 
TCGA Data PortalPAPSS2 
Broad Tumor PortalPAPSS2
OASIS PortalPAPSS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPAPSS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPAPSS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch PAPSS2
DgiDB (Drug Gene Interaction Database)PAPSS2
DoCM (Curated mutations)PAPSS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PAPSS2 (select a term)
intoGenPAPSS2
Cancer3DPAPSS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603005    612847   
Orphanet23563    12222   
MedgenPAPSS2
Genetic Testing Registry PAPSS2
NextProtO95340 [Medical]
TSGene9060
GENETestsPAPSS2
Target ValidationPAPSS2
Huge Navigator PAPSS2 [HugePedia]
snp3D : Map Gene to Disease9060
BioCentury BCIQPAPSS2
ClinGenPAPSS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9060
Chemical/Pharm GKB GenePA383
Clinical trialPAPSS2
Miscellaneous
canSAR (ICR)PAPSS2 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePAPSS2
EVEXPAPSS2
GoPubMedPAPSS2
iHOPPAPSS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:10:02 CEST 2017

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