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PARD3 (par-3 family cell polarity regulator)

Identity

Alias_namespar-3 (partitioning defective 3, C.elegans) homolog
par-3 partitioning defective 3 homolog (C. elegans)
Alias_symbol (synonym)PAR3
PARD3A
Bazooka
Baz
ASIP
PPP1R118
Other aliasPAR3alpha
PARD-3
SE2-5L16
SE2-5LT1
SE2-5T2
HGNC (Hugo) PARD3
LocusID (NCBI) 56288
Atlas_Id 49754
Location 10p11.22  [Link to chromosome band 10p11]
Location_base_pair Starts at 34109560 and ends at 34815325 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCNY (10p11.21) / PARD3 (10p11.22)CLDN1 (3q28) / PARD3 (10p11.22)FUK (16q22.1) / PARD3 (10p11.22)
GAD1 (2q31.1) / PARD3 (10p11.22)NCKAP1 (2q32.1) / PARD3 (10p11.22)NRP1 (10p11.22) / PARD3 (10p11.22)
PARD3 (10p11.22) / ADAMTS17 (15q26.3)PARD3 (10p11.22) / ARMC3 (10p12.2)PARD3 (10p11.22) / ARMC4 (10p12.1)
PARD3 (10p11.22) / CLDN1 (3q28)PARD3 (10p11.22) / COL6A3 (2q37.3)PARD3 (10p11.22) / CUL2 (10p11.21)
PARD3 (10p11.22) / FAM134B (5p15.1)PARD3 (10p11.22) / KDM3A (2p11.2)PARD3 (10p11.22) / PARD3 (10p11.22)
PARD3 (10p11.22) / PLEKHA2 (8p11.22)PARD3 (10p11.22) / TRAPPC8 (18q12.1)PARD3 (10p11.22) / ZNF521 (18q11.2)
PTAR1 (9q21.12) / PARD3 (10p11.22)SLC39A1 (1q21.3) / PARD3 (10p11.22)ZNF33A (10p11.1) / PARD3 (10p11.22)
NCKAP1 2q32.1 / PARD3 10p11.22PARD3 10p11.22 / ADAMTS17 15q26.3PARD3 10p11.22 / ARMC3 10p12.2
PARD3 10p11.22 / ARMC4 10p12.1PARD3 10p11.22 / CUL2 10p11.21PARD3 10p11.22 / ZNF521 18q11.2
ZNF33A 10p11.1 / PARD3 10p11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PARD3   16051
Cards
Entrez_Gene (NCBI)PARD3  56288  par-3 family cell polarity regulator
AliasesASIP; Baz; PAR3; PAR3alpha; 
PARD-3; PARD3A; PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2
GeneCards (Weizmann)PARD3
Ensembl hg19 (Hinxton)ENSG00000148498 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148498 [Gene_View]  chr10:34109560-34815325 [Contig_View]  PARD3 [Vega]
ICGC DataPortalENSG00000148498
TCGA cBioPortalPARD3
AceView (NCBI)PARD3
Genatlas (Paris)PARD3
WikiGenes56288
SOURCE (Princeton)PARD3
Genetics Home Reference (NIH)PARD3
Genomic and cartography
GoldenPath hg38 (UCSC)PARD3  -     chr10:34109560-34815325 -  10p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PARD3  -     10p11.22   [Description]    (hg19-Feb_2009)
EnsemblPARD3 - 10p11.22 [CytoView hg19]  PARD3 - 10p11.22 [CytoView hg38]
Mapping of homologs : NCBIPARD3 [Mapview hg19]  PARD3 [Mapview hg38]
OMIM606745   
Gene and transcription
Genbank (Entrez)AA136967 AB073671 AF177228 AF196185 AF196186
RefSeq transcript (Entrez)NM_001184785 NM_001184786 NM_001184787 NM_001184788 NM_001184789 NM_001184790 NM_001184791 NM_001184792 NM_001184793 NM_001184794 NM_019619
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PARD3
Cluster EST : UnigeneHs.131489 [ NCBI ]
CGAP (NCI)Hs.131489
Alternative Splicing GalleryENSG00000148498
Gene ExpressionPARD3 [ NCBI-GEO ]   PARD3 [ EBI - ARRAY_EXPRESS ]   PARD3 [ SEEK ]   PARD3 [ MEM ]
Gene Expression Viewer (FireBrowse)PARD3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56288
GTEX Portal (Tissue expression)PARD3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TEW0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TEW0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TEW0
Splice isoforms : SwissVarQ8TEW0
PhosPhoSitePlusQ8TEW0
Domaine pattern : Prosite (Expaxy)PDZ (PS50106)   
Domains : Interpro (EBI)DUF3534    PDZ   
Domain families : Pfam (Sanger)DUF3534 (PF12053)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam12053    pfam00595   
Domain families : Smart (EMBL)PDZ (SM00228)  
Conserved Domain (NCBI)PARD3
DMDM Disease mutations56288
Blocks (Seattle)PARD3
PDB (SRS)2KOM   
PDB (PDBSum)2KOM   
PDB (IMB)2KOM   
PDB (RSDB)2KOM   
Structural Biology KnowledgeBase2KOM   
SCOP (Structural Classification of Proteins)2KOM   
CATH (Classification of proteins structures)2KOM   
SuperfamilyQ8TEW0
Human Protein AtlasENSG00000148498
Peptide AtlasQ8TEW0
HPRD05994
IPIIPI00154915   IPI00301595   IPI00179063   IPI00163608   IPI00163607   IPI00045423   IPI00165621   IPI00301605   IPI00984283   IPI00294934   IPI00301597   
Protein Interaction databases
DIP (DOE-UCLA)Q8TEW0
IntAct (EBI)Q8TEW0
FunCoupENSG00000148498
BioGRIDPARD3
STRING (EMBL)PARD3
ZODIACPARD3
Ontologies - Pathways
QuickGOQ8TEW0
Ontology : AmiGOprotein binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  cytosol  cytoskeleton  plasma membrane  cell-cell junction  cell-cell junction  bicellular tight junction  bicellular tight junction  cell cortex  protein complex assembly  protein targeting to membrane  cell cycle  establishment or maintenance of cell polarity  transforming growth factor beta receptor signaling pathway  protein kinase C-activating G-protein coupled receptor signaling pathway  axonogenesis  asymmetric cell division  negative regulation of peptidyl-threonine phosphorylation  endomembrane system  protein phosphatase binding  myelination in peripheral nervous system  cell junction  cell junction  positive regulation of myelination  phosphatidylinositol-3-phosphate binding  internode region of axon  neuronal cell body  protein complex  axonal growth cone  regulation of cellular localization  bicellular tight junction assembly  bicellular tight junction assembly  establishment of epithelial cell polarity  
Ontology : EGO-EBIprotein binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  cytosol  cytoskeleton  plasma membrane  cell-cell junction  cell-cell junction  bicellular tight junction  bicellular tight junction  cell cortex  protein complex assembly  protein targeting to membrane  cell cycle  establishment or maintenance of cell polarity  transforming growth factor beta receptor signaling pathway  protein kinase C-activating G-protein coupled receptor signaling pathway  axonogenesis  asymmetric cell division  negative regulation of peptidyl-threonine phosphorylation  endomembrane system  protein phosphatase binding  myelination in peripheral nervous system  cell junction  cell junction  positive regulation of myelination  phosphatidylinositol-3-phosphate binding  internode region of axon  neuronal cell body  protein complex  axonal growth cone  regulation of cellular localization  bicellular tight junction assembly  bicellular tight junction assembly  establishment of epithelial cell polarity  
Pathways : KEGGRap1 signaling pathway    Chemokine signaling pathway    Neuroactive ligand-receptor interaction    Endocytosis    Hippo signaling pathway    Adherens junction    Tight junction   
NDEx NetworkPARD3
Atlas of Cancer Signalling NetworkPARD3
Wikipedia pathwaysPARD3
Orthology - Evolution
OrthoDB56288
GeneTree (enSembl)ENSG00000148498
Phylogenetic Trees/Animal Genes : TreeFamPARD3
HOVERGENQ8TEW0
HOGENOMQ8TEW0
Homologs : HomoloGenePARD3
Homology/Alignments : Family Browser (UCSC)PARD3
Gene fusions - Rearrangements
Fusion : MitelmanCCNY/PARD3 [10p11.21/10p11.22]  [t(10;10)(p11;p11)]  
Fusion : MitelmanNCKAP1/PARD3 [2q32.1/10p11.22]  [t(2;10)(q32;p11)]  
Fusion : MitelmanPARD3/ADAMTS17 [10p11.22/15q26.3]  [t(10;15)(p11;q26)]  
Fusion : MitelmanPARD3/ARMC3 [10p11.22/10p12.2]  [t(10;10)(p11;p12)]  
Fusion : MitelmanPARD3/ARMC4 [10p11.22/10p12.1]  [t(10;10)(p11;p12)]  
Fusion : MitelmanPARD3/CUL2 [10p11.22/10p11.21]  [t(10;10)(p11;p11)]  
Fusion : MitelmanPARD3/ZNF521 [10p11.22/18q11.2]  [t(10;18)(p11;q11)]  
Fusion : MitelmanZNF33A/PARD3 [10p11.1/10p11.22]  [t(10;10)(p11;p11)]  
Fusion: TCGANCKAP1 2q32.1 PARD3 10p11.22 HNSC
Fusion: TCGAPARD3 10p11.22 ADAMTS17 15q26.3 PRAD
Fusion: TCGAPARD3 10p11.22 ARMC3 10p12.2 BRCA
Fusion: TCGAPARD3 10p11.22 ARMC4 10p12.1 HNSC
Fusion: TCGAPARD3 10p11.22 CUL2 10p11.21 BRCA
Fusion: TCGAPARD3 10p11.22 ZNF521 18q11.2 OV
Fusion: TCGAZNF33A 10p11.1 PARD3 10p11.22 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPARD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARD3
dbVarPARD3
ClinVarPARD3
1000_GenomesPARD3 
Exome Variant ServerPARD3
ExAC (Exome Aggregation Consortium)PARD3 (select the gene name)
Genetic variants : HAPMAP56288
Genomic Variants (DGV)PARD3 [DGVbeta]
DECIPHERPARD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPARD3 
Mutations
ICGC Data PortalPARD3 
TCGA Data PortalPARD3 
Broad Tumor PortalPARD3
OASIS PortalPARD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARD3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPARD3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PARD3
DgiDB (Drug Gene Interaction Database)PARD3
DoCM (Curated mutations)PARD3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PARD3 (select a term)
intoGenPARD3
Cancer3DPARD3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606745   
Orphanet
MedgenPARD3
Genetic Testing Registry PARD3
NextProtQ8TEW0 [Medical]
TSGene56288
GENETestsPARD3
Target ValidationPARD3
Huge Navigator PARD3 [HugePedia]
snp3D : Map Gene to Disease56288
BioCentury BCIQPARD3
ClinGenPARD3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56288
Chemical/Pharm GKB GenePA32936
Clinical trialPARD3
Miscellaneous
canSAR (ICR)PARD3 (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePARD3
EVEXPARD3
GoPubMedPARD3
iHOPPARD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:23:45 CEST 2017

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