PARD3 (par-3 family cell polarity regulator)

2007-10-01  

Identity

HGNC
LOCATION
10p11.22
LOCUSID
ALIAS
ASIP,Baz,PAR3,PAR3alpha,PARD-3,PARD3A,PPP1R118,SE2-5L16,SE2-5LT1,SE2-5T2
FUSION GENES

Other Information

Locus ID:

NCBI: 56288
MIM: 606745
HGNC: 16051
Ensembl: ENSG00000148498

Variants:

dbSNP: 56288
ClinVar: 56288
TCGA: ENSG00000148498
COSMIC: PARD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148498ENST00000340077Q8TEW0
ENSG00000148498ENST00000346874Q8TEW0
ENSG00000148498ENST00000350537Q8TEW0
ENSG00000148498ENST00000374768B1AP52
ENSG00000148498ENST00000374773Q5VWU8
ENSG00000148498ENST00000374776Q8TEW0
ENSG00000148498ENST00000374788Q8TEW0
ENSG00000148498ENST00000374789Q8TEW0
ENSG00000148498ENST00000374790Q5VWV2
ENSG00000148498ENST00000374794Q8TEW0
ENSG00000148498ENST00000544292F5GZI3
ENSG00000148498ENST00000545260Q8TEW0
ENSG00000148498ENST00000545693Q8TEW0

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Axon guidanceKEGGko04360
Adherens junctionKEGGko04520
Tight junctionKEGGko04530
Neuroactive ligand-receptor interactionKEGGhsa04080
Axon guidanceKEGGhsa04360
Adherens junctionKEGGhsa04520
Tight junctionKEGGhsa04530
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)REACTOMER-HSA-2173791
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176091072007Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3.157
211700302011Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.126
209334262010Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins.108
231535342012Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis.101
183193012008Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
232632782013Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion.77
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62

Citation

Dessen P

PARD3 (par-3 family cell polarity regulator)

Atlas Genet Cytogenet Oncol Haematol. 2007-10-01

Online version: http://atlasgeneticsoncology.org/gene/49754/pard3